| dbo:abstract |
El TIK-301 (LY-156735) es un agonista de los receptores de melatonina llamados MT1 y MT2 que está en desarrollo para el tratamiento del insomnio y otros trastornos del sueño. Su acción agonista sobre los receptores: receptor de melatonina 1A (MT1) y receptor de melatonina 1B (MT2), en el núcleo supraquiasmático del cerebro permite su acción como . Pertenece a la misma clase de agonistas del receptor de melatonina que el y el . (es) TIK-301 (LY-156735) is an agonist for the melatonin receptors MT1 and MT2 that is under development for the treatment of insomnia and other sleep disorders. Its agonist action on MT1 and MT2 receptors in the suprachiasmatic nucleus in the brain enables its action as a chronobiotic. It is in the same class of melatonin receptor agonists as ramelteon and tasimelteon. (en) |
| dbo:casNumber |
118702-11-7 |
| dbo:chEMBL |
4079759 |
| dbo:fdaUniiCode |
3ZX95B1ZWK |
| dbo:pubchem |
219018 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/LY-156735.png?width=300 |
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| dbo:wikiPageWikiLink |
dbc:5-HT2B_antagonists dbr:Enantiomer dbr:Melatonin_receptor dbr:Melatonin_receptor_agonist dbr:Area_under_the_curve_(pharmacokinetics) dbr:EC50 dbr:Investigational_New_Drug dbc:Acetamides dbc:Chlorobenzenes dbc:Phenol_ethers dbc:Sedatives dbc:Tryptamines dbr:Melatonin dbr:Orphan_drug dbr:Zolpidem dbr:Clinical_trials dbc:5-HT2C_antagonists dbr:Suprachiasmatic_nucleus dbr:Agomelatine dbr:Agonist dbr:Chronobiotic dbc:Melatonin_receptor_agonists dbr:Half-life dbr:Tasimelteon dbr:Bioavailability dbr:Insomnia dbr:Ramelteon dbr:Serotonin dbr:Mild_cognitive_impairment dbr:Somnolence dbr:Eli_Lilly_and_Co dbr:Phase_II_clinical_trial dbr:Phase_I_clinical_trial dbr:Circadian_rhythm_disorder dbr:5-HT2B dbr:5-HT2C dbr:Primary_insomnia dbr:Tikvah_Therapeutics_Inc. |
| dbp:c |
14 (xsd:integer) |
| dbp:casNumber |
118702 (xsd:integer) |
| dbp:chembl |
4079759 (xsd:integer) |
| dbp:chemspiderid |
189853 (xsd:integer) |
| dbp:cl |
1 (xsd:integer) |
| dbp:eliminationHalfLife |
3600.0 (dbd:second) |
| dbp:h |
17 (xsd:integer) |
| dbp:iupacName |
N-[-propyl]acetamide (en) |
| dbp:iupharLigand |
1351 (xsd:integer) |
| dbp:legalStatus |
Investigational (en) |
| dbp:n |
2 (xsd:integer) |
| dbp:o |
2 (xsd:integer) |
| dbp:pubchem |
219018 (xsd:integer) |
| dbp:routesOfAdministration |
Oral (en) |
| dbp:smiles |
C[C@@H]c1c[nH]c2c1ccOC (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
RKHCTAKUYDTFHE-QMMMGPOBSA-N (en) |
| dbp:synonyms |
Beta-methyl-6-chloromelatonin; LY-156735; PD-6735 (en) |
| dbp:unii |
3 (xsd:integer) |
| dbp:verifiedfields |
changed (en) |
| dbp:verifiedrevid |
451552925 (xsd:integer) |
| dbp:watchedfields |
changed (en) |
| dbp:width |
200 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Melatonergics dbt:Drugbox dbt:Reflist dbt:Serotonergics dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Fdacite dbt:Stdinchicite |
| dct:subject |
dbc:5-HT2B_antagonists dbc:Acetamides dbc:Chlorobenzenes dbc:Phenol_ethers dbc:Sedatives dbc:Tryptamines dbc:5-HT2C_antagonists dbc:Melatonin_receptor_agonists |
| gold:hypernym |
dbr:Agonist |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:Abstraction100002137 yago:Acetamide114711197 yago:Amide114724264 yago:Chemical114806838 yago:Compound114818238 yago:Element114840755 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Quintessence114847103 yago:Relation100031921 dbo:Drug yago:Substance100019613 yago:WikicatAcetamides yago:WikicatPhenolEthers umbel-rc:DrugProduct |
| rdfs:comment |
El TIK-301 (LY-156735) es un agonista de los receptores de melatonina llamados MT1 y MT2 que está en desarrollo para el tratamiento del insomnio y otros trastornos del sueño. Su acción agonista sobre los receptores: receptor de melatonina 1A (MT1) y receptor de melatonina 1B (MT2), en el núcleo supraquiasmático del cerebro permite su acción como . Pertenece a la misma clase de agonistas del receptor de melatonina que el y el . (es) TIK-301 (LY-156735) is an agonist for the melatonin receptors MT1 and MT2 that is under development for the treatment of insomnia and other sleep disorders. Its agonist action on MT1 and MT2 receptors in the suprachiasmatic nucleus in the brain enables its action as a chronobiotic. It is in the same class of melatonin receptor agonists as ramelteon and tasimelteon. (en) |
| rdfs:label |
TIK-301 (es) TIK-301 (en) |
| owl:sameAs |
yago-res:TIK-301 wikidata:TIK-301 dbpedia-es:TIK-301 https://global.dbpedia.org/id/4pkiG |
| prov:wasDerivedFrom |
wikipedia-en:TIK-301?oldid=1109268433&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/LY-156735.png |
| foaf:isPrimaryTopicOf |
wikipedia-en:TIK-301 |
| is dbo:wikiPageRedirects of |
dbr:LY-156,735 |
| is dbo:wikiPageWikiLink of |
dbr:Melatonin_receptor_agonist dbr:LY-156,735 |
| is foaf:primaryTopic of |
wikipedia-en:TIK-301 |
