| dbo:abstract |
TOX3 (None) هوَ بروتين يُشَفر بواسطة جين TOX3 في الإنسان. (ar) TOX high mobility group box family member 3, also known as TOX3, is a human gene. The protein encoded by this gene is a member of a subfamily of transcription factors that also includes TOX, TOX2, and TOX4 that share almost identical HMG-box DNA-binding domains which function to modify chromatin structure by unwinding and bending DNA. The protein TOX3 has a glutamine-rich C-terminus due to CAG repeats. TOX3 is located on human chromosome band 16q12.1. The gene consists of seven exons and is highly expressed in both the brain and luminal epithelial breast tissue. Mutations in the gene are associated with increased susceptibility to breast cancer. TOX3 plays a role in regulating calcium-dependent transcription and interacts with cAMP-response-element-binding protein (CREB) and CREB-binding protein (CBP). It also increases transcription via interaction with CITED1, a transcription co-regulator that increases transcription factor activity. (en) |
| dbo:arm |
q |
| dbo:band |
12.1 |
| dbo:chromosome |
16 |
| dbo:entrezgene |
27324 |
| dbo:hgncid |
11972 |
| dbo:omim |
611416 (xsd:integer) |
| dbo:refseq |
XM_049037 |
| dbo:symbol |
TNRC9, CAGF9 TOX3 |
| dbo:uniprot |
O15405 |
| dbo:wikiPageID |
19114761 (xsd:integer) |
| dbo:wikiPageLength |
7302 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1114138316 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Epithelial–mesenchymal_transition dbr:Breast_cancer dbr:DNA-binding_domain dbr:SNAI1 dbr:Gene dbr:Clear_cell_renal_cell_carcinoma dbr:Chromatin dbr:Transcription_factor dbr:Protein dbr:HMG-box dbr:BRCA1 dbr:BRCA2 dbc:Transcription_factors dbr:TOX dbr:CREB dbr:CREB-binding_protein dbr:CITED1 dbr:Single-nucleotide_polymorphism dbr:FOXA1 dbr:SNAI2 dbr:TOX4 dbr:TOX2 |
| dbp:altsymbols |
TNRC9, CAGF9 (en) |
| dbp:arm |
q (en) |
| dbp:band |
12.100000 (xsd:double) |
| dbp:chromosome |
16 (xsd:integer) |
| dbp:entrezgene |
27324 (xsd:integer) |
| dbp:hgncid |
11972 (xsd:integer) |
| dbp:name |
TOX high mobility group box family member 3 (en) |
| dbp:omim |
611416 (xsd:integer) |
| dbp:refseq |
XM_049037 (en) |
| dbp:symbol |
TOX3 (en) |
| dbp:uniprot |
O15405 (en) |
| dbp:wikiPageUsesTemplate |
dbt:Gene-20-stub dbt:Reflist dbt:Short_description dbt:Infobox_protein dbt:Transcription_factors |
| dct:subject |
dbc:Transcription_factors |
| gold:hypernym |
dbr:Gene |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:WikicatTranscriptionFactors yago:Abstraction100002137 yago:Beginning107290905 yago:Cause107326557 yago:Event100029378 yago:Factor107327805 yago:Happening107283608 yago:Origin107323922 yago:PsychologicalFeature100023100 yago:YagoPermanentlyLocatedEntity dbo:Protein |
| rdfs:comment |
TOX3 (None) هوَ بروتين يُشَفر بواسطة جين TOX3 في الإنسان. (ar) TOX high mobility group box family member 3, also known as TOX3, is a human gene. The protein encoded by this gene is a member of a subfamily of transcription factors that also includes TOX, TOX2, and TOX4 that share almost identical HMG-box DNA-binding domains which function to modify chromatin structure by unwinding and bending DNA. The protein TOX3 has a glutamine-rich C-terminus due to CAG repeats. TOX3 is located on human chromosome band 16q12.1. The gene consists of seven exons and is highly expressed in both the brain and luminal epithelial breast tissue. Mutations in the gene are associated with increased susceptibility to breast cancer. TOX3 plays a role in regulating calcium-dependent transcription and interacts with cAMP-response-element-binding protein (CREB) and CREB-binding p (en) |
| rdfs:label |
TOX3 (ar) TOX3 (en) |
| owl:sameAs |
freebase:TOX3 yago-res:TOX3 wikidata:TOX3 dbpedia-ar:TOX3 https://global.dbpedia.org/id/21WDL |
| prov:wasDerivedFrom |
wikipedia-en:TOX3?oldid=1114138316&ns=0 |
| foaf:isPrimaryTopicOf |
wikipedia-en:TOX3 |
| foaf:name |
TOX high mobility group box family member 3 (en) |
| is dbo:wikiPageWikiLink of |
dbr:List_of_human_protein-coding_genes_4 dbr:TOX dbr:TOX2 |
| is foaf:primaryTopic of |
wikipedia-en:TOX3 |