TRIB2 (original) (raw)
Tribbles homolog 2 is an atypical protein kinase that is encoded in human by the TRIB2 gene. TRIB2 is a pseudokinase member of the (pseudoenzyme) class of signaling/scaffold proteins, possessing little vestigial catalytic output in vitro. It is known to signal to canonical MAPK pathways and to regulate the ubiquitination of substrates with important functions in the immune system. It has also been associated with various diseases, especially in vertebrate leukaemia models. Like TRIB1 and TRIB3, TRIB2 has recently been considered as a potential allosteric drug target, and is a putative regulator of cancer-associated signalling and survival through AKT pSer473 modulation
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| dbo:abstract | Tribbles homolog 2 is an atypical protein kinase that is encoded in human by the TRIB2 gene. TRIB2 is a pseudokinase member of the (pseudoenzyme) class of signaling/scaffold proteins, possessing little vestigial catalytic output in vitro. It is known to signal to canonical MAPK pathways and to regulate the ubiquitination of substrates with important functions in the immune system. It has also been associated with various diseases, especially in vertebrate leukaemia models. Like TRIB1 and TRIB3, TRIB2 has recently been considered as a potential allosteric drug target, and is a putative regulator of cancer-associated signalling and survival through AKT pSer473 modulation (en) TRIB2 (англ. Tribbles pseudokinase 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 2-ї хромосоми. Довжина поліпептидного ланцюга білка становить 343 амінокислот, а молекулярна маса — 38 801. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Задіяний у такому біологічному процесі як поліморфізм. Локалізований у цитоплазмі, цитоскелеті. (uk) |
| dbo:wikiPageExternalLink | http://www.tara.tcd.ie/bitstream/2262/33449/1/Human%20tribbles%2c%20a%20protein%20family%20controlling%20mitogen-activated%20protein%20kinase%20cascades.pdf |
| dbo:wikiPageID | 15245616 (xsd:integer) |
| dbo:wikiPageLength | 6520 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1115552437 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:TRIB3 dbr:Pseudoenzyme dbr:Pseudokinase dbc:EC_2.7.11 dbr:Gene dbr:Protein_kinase dbr:TRIB1 |
| dbp:wikiPageUsesTemplate | dbt:Gene-2-stub dbt:Cite_journal dbt:Enzymes dbt:Infobox_gene dbt:Portal_bar dbt:Refbegin dbt:Refend dbt:Reflist dbt:Serine/threonine-specific_protein_kinases |
| dct:subject | dbc:EC_2.7.11 |
| gold:hypernym | dbr:Protein |
| rdf:type | owl:Thing dbo:Biomolecule dbo:Gene wikidata:Q206229 wikidata:Q7187 dbo:HumanGene dbo:Protein |
| rdfs:comment | Tribbles homolog 2 is an atypical protein kinase that is encoded in human by the TRIB2 gene. TRIB2 is a pseudokinase member of the (pseudoenzyme) class of signaling/scaffold proteins, possessing little vestigial catalytic output in vitro. It is known to signal to canonical MAPK pathways and to regulate the ubiquitination of substrates with important functions in the immune system. It has also been associated with various diseases, especially in vertebrate leukaemia models. Like TRIB1 and TRIB3, TRIB2 has recently been considered as a potential allosteric drug target, and is a putative regulator of cancer-associated signalling and survival through AKT pSer473 modulation (en) TRIB2 (англ. Tribbles pseudokinase 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 2-ї хромосоми. Довжина поліпептидного ланцюга білка становить 343 амінокислот, а молекулярна маса — 38 801. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Задіяний у такому біологічному процесі як поліморфізм. Локалізований у цитоплазмі, цитоскелеті. (uk) |
| rdfs:label | TRIB2 (en) TRIB2 (uk) |
| owl:sameAs | freebase:TRIB2 wikidata:TRIB2 http://tt.dbpedia.org/resource/TRIB2 dbpedia-uk:TRIB2 https://global.dbpedia.org/id/jfkY |
| prov:wasDerivedFrom | wikipedia-en:TRIB2?oldid=1115552437&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:TRIB2 |
| is dbo:wikiPageRedirects of | dbr:TRIB2_(gene) |
| is dbo:wikiPageWikiLink of | dbr:List_of_human_protein-coding_genes_4 dbr:TRIB3 dbr:The_Trouble_with_Tribbles dbr:TRIB2_(gene) dbr:Tribble_(disambiguation) dbr:CAMK dbr:TRIB1 dbr:Protein_kinase_domain |
| is foaf:primaryTopic of | wikipedia-en:TRIB2 |