| dbo:abstract |
TRIMU-5 is a selective agonist of the μ2-opioid receptor and antagonist of the μ1-opioid receptor. It produces analgesia in animals that differs from that of conventional μ-opioid receptor agonists but that can still be blocked by μ-opioid receptor antagonists. TRIMU-5 can also block the analgesic effects of μ-opioid receptor agonists like morphine. In addition to analgesia, TRIMU-5 inhibits gastrointestinal transit, a known effect of μ2-opioid receptor activation. (en) Il TRIMU 5 è un agonista selettivo dei recettori μ-oppioidi tipo 2. (it) |
| dbo:iupacName |
(L)-tyrosyl-N-{[(3-methylbutyl)amino]acetyl}-(D)-alaninamide (en) (2R)-2-Amino-3-(4-hydroxyphenyl)-N-[(2R)-1-{2-[(3-methylbutyl)amino]acetamido}-1-oxopropan-2-yl]propanamide (en) |
| dbo:thumbnail |
wiki-commons:Special:FilePath/TRIMU_5.png?width=300 |
| dbo:wikiPageID |
12892944 (xsd:integer) |
| dbo:wikiPageLength |
2947 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1052411053 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbc:Mu-opioid_receptor_agonists dbr:Morphine dbr:Receptor_antagonist dbr:Agonist dbr:Analgesia dbr:Μ-opioid_receptor dbc:Opioid_peptides dbr:Binding_selectivity dbr:Gastrointestinal_transit dbr:Μ1-opioid_receptor dbr:Μ2-opioid_receptor |
| dbp:imagefile |
TRIMU 5.png (en) |
| dbp:iupacname |
(L)-tyrosyl-N-{[amino]acetyl}-(D)-alaninamide (en) |
| dbp:pin |
-2 (xsd:integer) |
| dbp:verifiedfields |
changed (en) |
| dbp:verifiedrevid |
470482006 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Analgesic-stub dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Reflist dbt:Cascite dbt:Chemspidercite dbt:Stdinchicite dbt:Opioid_receptor_modulators |
| dcterms:subject |
dbc:Mu-opioid_receptor_agonists dbc:Opioid_peptides |
| gold:hypernym |
dbr:Agonist |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 yago:WikicatMolecularFormulas yago:WikicatOpioidPeptides yago:Abstraction100002137 yago:Amide114724264 yago:Chemical114806838 yago:Communication100033020 yago:Compound114818238 yago:Formula106816935 yago:Material114580897 yago:Matter100020827 yago:Message106598915 yago:MolecularFormula106817173 yago:OrganicCompound114727670 yago:Part113809207 yago:Peptide114743046 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:ChemicalCompound dbo:Drug yago:Statement106722453 yago:Substance100019613 |
| rdfs:comment |
TRIMU-5 is a selective agonist of the μ2-opioid receptor and antagonist of the μ1-opioid receptor. It produces analgesia in animals that differs from that of conventional μ-opioid receptor agonists but that can still be blocked by μ-opioid receptor antagonists. TRIMU-5 can also block the analgesic effects of μ-opioid receptor agonists like morphine. In addition to analgesia, TRIMU-5 inhibits gastrointestinal transit, a known effect of μ2-opioid receptor activation. (en) Il TRIMU 5 è un agonista selettivo dei recettori μ-oppioidi tipo 2. (it) |
| rdfs:label |
TRIMU 5 (it) TRIMU 5 (en) |
| owl:sameAs |
freebase:TRIMU 5 yago-res:TRIMU 5 wikidata:TRIMU 5 dbpedia-it:TRIMU 5 dbpedia-sh:TRIMU 5 dbpedia-sr:TRIMU 5 https://global.dbpedia.org/id/4vkFE |
| prov:wasDerivedFrom |
wikipedia-en:TRIMU_5?oldid=1052411053&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/TRIMU_5.png |
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wikipedia-en:TRIMU_5 |
| is dbo:wikiPageRedirects of |
dbr:C19H30N4O4 dbr:TRIMU-5 |
| is dbo:wikiPageWikiLink of |
dbr:List_of_opioids dbr:C19H30N4O4 dbr:Μ-opioid_receptor dbr:Opioid dbr:TRIMU-5 |
| is foaf:primaryTopic of |
wikipedia-en:TRIMU_5 |
