| dbo:abstract |
Talarozole (formerly R115866, planned trade name Rambazole) was an investigational drug for the treatment of acne, psoriasis and other keratinization disorders. Development has been discontinued. Talarozole inhibits the metabolism of retinoic acid by blocking cytochrome P450 enzyme CYP26 isoenzymes (CYP26A1 and possibly also CYP26B1), retinoic acid hydroxylases. Because of this mechanism, it is called a (RAMBA). It has 750-fold higher potency than the earlier drug liarozole as well as greater selectivity, with more than 300-fold selectivity for inhibition of CYP26A1 over other steroid-metabolizing enzymes like CYP17A1 (17α-hydroxylase/17,20-lyase) and aromatase (CYP19A1). (en) |
| dbo:casNumber |
201410-53-9 |
| dbo:chEBI |
101854 |
| dbo:fdaUniiCode |
XKD9N5CJ6W |
| dbo:pubchem |
9799888 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Talarozole_skeletal.svg?width=300 |
| dbo:wikiPageExternalLink |
http://adisinsight.springer.com/drugs/800020802 |
| dbo:wikiPageID |
21562001 (xsd:integer) |
| dbo:wikiPageLength |
4186 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1056774756 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Potency_(pharmacology) dbr:Psoriasis dbr:Hydroxylase dbr:Retinoic_acid dbr:Cytochrome_P450 dbc:Triazoles dbr:Oral_administration dbr:Aromatase dbr:Liarozole dbr:CYP17A1 dbc:Anti-acne_preparations dbc:Benzothiazoles dbr:Acne dbr:Binding_selectivity dbr:CYP26A1 dbr:CYP26B1 dbr:Keratinization dbr:Isoenzyme dbr:Retinoic_acid_metabolism_blocking_agent |
| dbp:atcPrefix |
none (en) |
| dbp:c |
21 (xsd:integer) |
| dbp:casNumber |
201410 (xsd:integer) |
| dbp:chebi |
101854 (xsd:integer) |
| dbp:chemspiderid |
7975653 (xsd:integer) |
| dbp:h |
23 (xsd:integer) |
| dbp:iupacName |
N--N-[4-[2-ethyl-1-butyl]phenyl]amine (en) |
| dbp:n |
5 (xsd:integer) |
| dbp:pubchem |
9799888 (xsd:integer) |
| dbp:routesOfAdministration |
By mouth, topical (en) |
| dbp:s |
1 (xsd:integer) |
| dbp:smiles |
c2ncnn2Ccccc3Nc4nc1ccccc1s4 (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
SNFYYXUGUBUECJ-UHFFFAOYSA-N (en) |
| dbp:unii |
XKD9N5CJ6W (en) |
| dbp:verifiedfields |
changed (en) |
| dbp:verifiedrevid |
451730052 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Dermatologic-drug-stub dbt:Drugbox dbt:Reflist dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Ebicite dbt:Fdacite dbt:Stdinchicite |
| dcterms:subject |
dbc:Triazoles dbc:Anti-acne_preparations dbc:Benzothiazoles |
| gold:hypernym |
dbr:Drug |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment |
Talarozole (formerly R115866, planned trade name Rambazole) was an investigational drug for the treatment of acne, psoriasis and other keratinization disorders. Development has been discontinued. Talarozole inhibits the metabolism of retinoic acid by blocking cytochrome P450 enzyme CYP26 isoenzymes (CYP26A1 and possibly also CYP26B1), retinoic acid hydroxylases. Because of this mechanism, it is called a (RAMBA). (en) |
| rdfs:label |
Talarozole (en) |
| owl:sameAs |
freebase:Talarozole wikidata:Talarozole dbpedia-sh:Talarozole dbpedia-sr:Talarozole https://global.dbpedia.org/id/YcEU |
| prov:wasDerivedFrom |
wikipedia-en:Talarozole?oldid=1056774756&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Talarozole_skeletal.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Talarozole |
| is dbo:wikiPageRedirects of |
dbr:Rambazole dbr:R115866 |
| is dbo:wikiPageWikiLink of |
dbr:List_of_drugs:_T–Td dbr:Rambazole dbr:R115866 |
| is foaf:primaryTopic of |
wikipedia-en:Talarozole |
