| dbo:abstract |
Technetium (99mTc) mebrofenin is a diagnostic radiopharmaceutical used for imaging of the liver and the gallbladder. Under the brand name Choletec it is available from Bracco Diagnostic. Supplied as a sterile kit of mebrofenin and dehydrated stannous fluoride. The vial is reconstituted with 1 to 5 mL up to 3.7 gigabecquerels (100 mCi) of sodium pertechnetate solution to form the final radio labeled 99mTc mebrofenin. Upon intravenous administration, 99mTc mebrofenin bound to plasma proteins is cleared from systemic circulation in approximately 5 minutes by hepatocytes, while maximal liver uptake occurs within 11 minutes. Mechanism of mebrofenin entering the gallbladder is thought to occur with a mechanism similar to bilirubin clearance. Normal adult patient (70 kg) dose with normal serum bilirubin levels of less than 1.5 mg/dL is 2 to 5 mCi. Increased serum bilirubin increases renal clearance, decreases hepatic uptake and increases visualization time, thus a higher dose of 3 to 10 mCi is recommended. Doses higher than 10 mCi are seldom used. Obese patients require increased dose of 2 to 3 mCi compared with the normal adult patient dose to obtain proper visualization. (en) |
| dbo:alternativeName |
Choletec (en) |
| dbo:chemicalFormula |
99mTc3+(C15H17BrN2O5)2−2 |
| dbo:fdaUniiCode |
F2NQ468L52 |
| dbo:pubchem |
11431716 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Technetium_(99mTc)_mebrofenin_skeletal.svg?width=300 |
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34062870 (xsd:integer) |
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8269 (xsd:nonNegativeInteger) |
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| dbo:wikiPageWikiLink |
dbc:Technetium-99m dbc:Technetium_compounds dbr:Hepatobiliary dbr:Bracco_(company) dbr:Cholelithiasis dbr:Radiopharmaceutical dbr:Cirrhosis dbr:Gallbladder dbr:Phenyl_ring dbr:Lidocaine dbr:Liver dbr:Cholecystokinin dbr:Common_bile_duct dbr:Technetium-99m dbr:Chelate dbr:Sodium_pertechnetate dbr:Meperidine dbr:Sclerosing_cholangitis dbr:Morphine_sulfate dbr:Acute_cholecystitis dbr:Child-Pugh dbr:Stannous_fluoride dbr:2-(3-bromo-2,4,6-trimethylani...cetate)_technetium_(99mTc) dbr:Gall_bladder_ejection_fraction |
| dbp:atcPrefix |
V09 (en) |
| dbp:atcSuffix |
DA04 (en) |
| dbp:chemicalFormula |
99 (xsd:integer) |
| dbp:iupacName |
Bis (en) |
| dbp:legalUs |
Rx-only (en) |
| dbp:molecularWeight |
869.300000 (xsd:double) |
| dbp:pregnancyUs |
C (en) |
| dbp:pubchem |
11431716 (xsd:integer) |
| dbp:tradename |
Choletec (en) |
| dbp:unii |
F2NQ468L52 (en) |
| dbp:wikiPageUsesTemplate |
dbt:Convert dbt:Drugbox dbt:Reflist dbt:Drugs.com |
| dcterms:subject |
dbc:Technetium-99m dbc:Technetium_compounds |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:Abstraction100002137 yago:Cognition100023271 yago:Compound105870180 yago:Concept105835747 yago:Content105809192 yago:Idea105833840 yago:PsychologicalFeature100023100 dbo:Drug yago:Whole105869584 yago:WikicatTechnetiumCompounds |
| rdfs:comment |
Technetium (99mTc) mebrofenin is a diagnostic radiopharmaceutical used for imaging of the liver and the gallbladder. Under the brand name Choletec it is available from Bracco Diagnostic. Supplied as a sterile kit of mebrofenin and dehydrated stannous fluoride. The vial is reconstituted with 1 to 5 mL up to 3.7 gigabecquerels (100 mCi) of sodium pertechnetate solution to form the final radio labeled 99mTc mebrofenin. (en) |
| rdfs:label |
Technetium (99mTc) mebrofenin (en) |
| owl:sameAs |
freebase:Technetium (99mTc) mebrofenin yago-res:Technetium (99mTc) mebrofenin wikidata:Technetium (99mTc) mebrofenin https://global.dbpedia.org/id/4vZui |
| prov:wasDerivedFrom |
wikipedia-en:Technetium_(99mTc)_mebrofenin?oldid=1007150367&ns=0 |
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wiki-commons:Special:FilePath/Technetium_(99mTc)_mebrofenin_skeletal.svg |
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wikipedia-en:Technetium_(99mTc)_mebrofenin |
| is dbo:wikiPageRedirects of |
dbr:ATC_code_V09DA04 dbr:ATCvet_code_QV09DA04 dbr:Mebrofenin |
| is dbo:wikiPageWikiLink of |
dbr:ATC_code_V09DA04 dbr:ATCvet_code_QV09DA04 dbr:ATC_code_V09 dbr:Mebrofenin dbr:List_of_drugs:_Te |
| is foaf:primaryTopic of |
wikipedia-en:Technetium_(99mTc)_mebrofenin |
