| dbo:abstract |
إيثيل التلوتريستات (بالإنجليزية: Telotristat ethyl) هو دواء أولي يُستعمل في علاج: * المتلازمة السرطاوية * الورم السرطاوي (ar) Telotristat ethyl (USAN, brand name Xermelo) is a prodrug of telotristat, which is an inhibitor of tryptophan hydroxylase. It is formulated as telotristat etiprate — a hippurate salt of telotristat ethyl. On February 28, 2017, the U.S. Food and Drug Administration (FDA) approved telotristat ethyl in combination with somatostatin analog (SSA) therapy for the treatment of adults with diarrhea associated with carcinoid syndrome that SSA therapy alone has inadequately controlled. Telotristat ethyl was approved for use in the European Union in September 2017. The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication. (en) Telotristat etil, etiltelotristato, , telotristato de etila ou telotristat ethyl é um pró-fármaco de telotristat, o qual é um inibitor de triptofano hidroxilase. É formulado como etiprato de telotristat — um sal do telotristat etil. Em 28 de fevereiro de 2017, a Administração de Alimentos e Medicamentos dos EUA aprovou o medicamento Xermelo em combinação com a terapia de análogos de somatostatina (SSA) para o tratamento de adultos com diarreia associada à síndrome carcinoide, que a terapia SSA sozinha tem controlado inadequadamente. (pt) |
| dbo:alternativeName |
Xermelo (en) |
| dbo:casNumber |
1033805-22-9 |
| dbo:chEMBL |
2105695 |
| dbo:drugbank |
DB12095 |
| dbo:fdaUniiCode |
8G388563M7 |
| dbo:kegg |
D09974 D09975 |
| dbo:medlinePlus |
a617029 |
| dbo:pubchem |
25181577 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Telotristat_ethyl.svg?width=300 |
| dbo:wikiPageExternalLink |
https://druginfo.nlm.nih.gov/drugportal/name/telotristat%20ethyl https://druginfo.nlm.nih.gov/drugportal/name/telotristat%20etiprate |
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dbr:Carcinoid_syndrome dbc:Amines dbc:Chloroarenes dbc:Guanidines dbc:Phenethylamines dbc:Prodrugs dbc:Trifluoromethyl_compounds dbr:Oral_administration dbr:Lexicon_Pharmaceuticals dbr:Feces dbr:Prodrug dbc:Pyrazoles dbr:Food_and_Drug_Administration dbr:Carboxylesterase dbr:Diarrhea dbr:Rate-determining_step dbc:Aminopyrimidines dbc:Ethyl_esters dbr:Hippuric_acid dbr:Hydrolysis dbr:Tryptophan_hydroxylase dbc:Tryptophan_hydroxylase_inhibitors dbr:Tablet_(pharmacy) dbr:Serotonin dbr:Somatostatin dbr:United_States_Adopted_Name dbr:Urine dbr:First-in-class_medication dbr:File:Action_of_telotristat_on_tryptophan_hydroxylase.svg dbr:File:Telotristat_etiprate.svg |
| dbp:atcPrefix |
A16 (en) |
| dbp:atcSuffix |
AX15 (en) |
| dbp:c |
27 (xsd:integer) |
| dbp:casNumber |
1033805 (xsd:integer) |
| dbp:chembl |
2105695 (xsd:integer) |
| dbp:chemspiderid |
28189674 (xsd:integer) |
| dbp:cl |
1 (xsd:integer) |
| dbp:dailymedid |
Telotristat_ethyl (en) |
| dbp:drugbank |
DB12095 (en) |
| dbp:eliminationHalfLife |
18000.0 |
| dbp:excretion |
dbr:Feces dbr:Urine |
| dbp:f |
3 (xsd:integer) |
| dbp:h |
26 (xsd:integer) |
| dbp:index2Label |
as etiprate (en) |
| dbp:iupacName |
[-Ethyl 2-amino-3-propanoate] (en) |
| dbp:kegg |
D09974 (en) D09975 (en) |
| dbp:legalAu |
S4 (en) |
| dbp:legalCa |
Rx-only (en) |
| dbp:legalEu |
Rx-only (en) |
| dbp:legalUk |
POM (en) |
| dbp:legalUs |
Rx-only (en) |
| dbp:medlineplus |
a617029 (en) |
| dbp:metabolism |
Hydrolysis via carboxylesterases (en) |
| dbp:metabolites |
Telotristat (en) |
| dbp:n |
6 (xsd:integer) |
| dbp:o |
3 (xsd:integer) |
| dbp:pregnancyAu |
B3 (en) |
| dbp:proteinBound |
>99% (en) |
| dbp:pubchem |
25181577 (xsd:integer) |
| dbp:routesOfAdministration |
By mouth (en) |
| dbp:smiles |
CCOCCN (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
MDSQOJYHHZBZKA-GBXCKJPGSA-N (en) |
| dbp:synonyms |
LX1032, LX1606 (en) |
| dbp:tradename |
Xermelo (en) |
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8 (xsd:integer) |
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275 (xsd:integer) |
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dbt:Cite_journal dbt:Cite_web dbt:Clear_left dbt:Drugbox dbt:Portal_bar dbt:Reflist dbt:Drugs.com dbt:Monoamine_metabolism_modulators |
| dcterms:subject |
dbc:Amines dbc:Chloroarenes dbc:Guanidines dbc:Phenethylamines dbc:Prodrugs dbc:Trifluoromethyl_compounds dbc:Pyrazoles dbc:Aminopyrimidines dbc:Ethyl_esters dbc:Tryptophan_hydroxylase_inhibitors |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment |
إيثيل التلوتريستات (بالإنجليزية: Telotristat ethyl) هو دواء أولي يُستعمل في علاج: * المتلازمة السرطاوية * الورم السرطاوي (ar) Telotristat etil, etiltelotristato, , telotristato de etila ou telotristat ethyl é um pró-fármaco de telotristat, o qual é um inibitor de triptofano hidroxilase. É formulado como etiprato de telotristat — um sal do telotristat etil. Em 28 de fevereiro de 2017, a Administração de Alimentos e Medicamentos dos EUA aprovou o medicamento Xermelo em combinação com a terapia de análogos de somatostatina (SSA) para o tratamento de adultos com diarreia associada à síndrome carcinoide, que a terapia SSA sozinha tem controlado inadequadamente. (pt) Telotristat ethyl (USAN, brand name Xermelo) is a prodrug of telotristat, which is an inhibitor of tryptophan hydroxylase. It is formulated as telotristat etiprate — a hippurate salt of telotristat ethyl. On February 28, 2017, the U.S. Food and Drug Administration (FDA) approved telotristat ethyl in combination with somatostatin analog (SSA) therapy for the treatment of adults with diarrhea associated with carcinoid syndrome that SSA therapy alone has inadequately controlled. Telotristat ethyl was approved for use in the European Union in September 2017. (en) |
| rdfs:label |
إيثيل التلوتريستات (ar) Telotristat ethyl (en) Telotristat etil (pt) |
| owl:sameAs |
yago-res:Telotristat ethyl wikidata:Telotristat ethyl dbpedia-ar:Telotristat ethyl dbpedia-he:Telotristat ethyl dbpedia-pt:Telotristat ethyl https://global.dbpedia.org/id/2YVFm |
| prov:wasDerivedFrom |
wikipedia-en:Telotristat_ethyl?oldid=1095944685&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Action_of_telotristat_on_tryptophan_hydroxylase.svg wiki-commons:Special:FilePath/Telotristat_ethyl.svg wiki-commons:Special:FilePath/Telotristat_etiprate.svg |
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wikipedia-en:Telotristat_ethyl |
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dbr:Telotristat_etiprate dbr:Telotristat dbr:Xermelo |
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dbr:Carcinoid_syndrome dbr:Lexicon_Pharmaceuticals dbr:Matthew_Kulke dbr:Fenclonine dbr:C38H46F4N6O9S dbr:Telotristat_etiprate dbr:Telotristat dbr:Xermelo |
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wikipedia-en:Telotristat_ethyl |
