Tenomodulin (original) (raw)
Tenomodulin, also referred to as tendin, myodulin, Tnmd, or TeM, is a protein encoded by the TNMD (Tnmd) gene and was discovered independently by Brandau and Shukunami in 2001 as a gene sharing high similarity with the already known chondromodulin-1 (Chm1). It is a tendon-specific gene marker known to be important for tendon maturation with key implications for the residing tendon stem/progenitor cells (TSPCs) as well as for the regulation of endothelial cell migration in chordae tendineae cordis in the heart and in experimental tumour models. It is highly expressed in tendons, explaining the rationale behind its name and the establishment as being marker gene for tendinous and ligamentous lineages.
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| dbo:abstract | Tenomodulin, also referred to as tendin, myodulin, Tnmd, or TeM, is a protein encoded by the TNMD (Tnmd) gene and was discovered independently by Brandau and Shukunami in 2001 as a gene sharing high similarity with the already known chondromodulin-1 (Chm1). It is a tendon-specific gene marker known to be important for tendon maturation with key implications for the residing tendon stem/progenitor cells (TSPCs) as well as for the regulation of endothelial cell migration in chordae tendineae cordis in the heart and in experimental tumour models. It is highly expressed in tendons, explaining the rationale behind its name and the establishment as being marker gene for tendinous and ligamentous lineages. (en) TNMD (англ. Tenomodulin) – білок, який кодується однойменним геном, розташованим у людей на X-хромосомі. Довжина поліпептидного ланцюга білка становить 317 амінокислот, а молекулярна маса — 37 130. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функцією належить до фосфопротеїнів. Задіяний у такому біологічному процесі, як альтернативний сплайсинг. Локалізований у цитоплазмі, ядрі, мембрані. (uk) |
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| dbo:wikiPageWikiLink | dbr:Atrioventricular_valves dbr:Melanoma dbr:Glycoproteins dbr:LECT1 dbr:Dentate_gyrus dbr:Papillary_muscle dbr:Cerebellum dbc:Extracellular_matrix_proteins dbr:Angiogenesis dbr:Hippocampus dbr:Knockout_mouse dbr:Retinal_ganglion_cell dbr:Tendons dbr:Achilles_tendon dbr:Fibroblast dbr:Purkinje_cells dbr:Obesity dbr:Mitral_regurgitation dbr:Scleraxis dbr:Valvular_heart_disease dbr:Mouse_brain dbr:Chordae_tendineae_cordis dbr:VEGF-A dbr:N-glycosylation dbr:Collagen_I |
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| dcterms:subject | dbc:Extracellular_matrix_proteins |
| gold:hypernym | dbr:Protein |
| rdf:type | owl:Thing dbo:Biomolecule dbo:Gene wikidata:Q206229 wikidata:Q7187 yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:HumanGene dbo:Protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatExtracellularMatrixProteins |
| rdfs:comment | Tenomodulin, also referred to as tendin, myodulin, Tnmd, or TeM, is a protein encoded by the TNMD (Tnmd) gene and was discovered independently by Brandau and Shukunami in 2001 as a gene sharing high similarity with the already known chondromodulin-1 (Chm1). It is a tendon-specific gene marker known to be important for tendon maturation with key implications for the residing tendon stem/progenitor cells (TSPCs) as well as for the regulation of endothelial cell migration in chordae tendineae cordis in the heart and in experimental tumour models. It is highly expressed in tendons, explaining the rationale behind its name and the establishment as being marker gene for tendinous and ligamentous lineages. (en) TNMD (англ. Tenomodulin) – білок, який кодується однойменним геном, розташованим у людей на X-хромосомі. Довжина поліпептидного ланцюга білка становить 317 амінокислот, а молекулярна маса — 37 130. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | Tenomodulin (en) TNMD (uk) |
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