| dbo:abstract |
Thioacetazone (INN, BAN), also known as amithiozone (USAN), is an oral antibiotic which is used in the treatment of tuberculosis. It has fallen into almost complete disuse due to toxicity and the introduction of improved anti-tuberculosis drugs like isoniazid. The drug has only weak activity against Mycobacterium tuberculosis and is only useful in preventing resistance to more powerful drugs such as isoniazid and rifampicin. It is never used on its own to treat tuberculosis; it is used in a similar way to ethambutol. There is no advantage to using thioacetazone if the regimen used already contains ethambutol, but many countries in sub-Saharan Africa still use thioacetazone because it is extremely cheap. Use of thioacetazone is declining because it can cause severe (sometimes fatal) skin reactions in HIV positive patients. The biological target of thioacetazone has proven elusive and its mechanism of action remains unknown, although it is thought to interfere with mycolic acid synthesis. (en) Il tiacetazone è un derivato dai sulfamidici contenenti , ma risulta meno tossico e più efficace di questi ultimi. (it) |
| dbo:alternativeName |
Conteben (en) |
| dbo:casNumber |
104-06-3 |
| dbo:chEMBL |
375492 |
| dbo:fdaUniiCode |
MMG78X7SSR |
| dbo:kegg |
D08584 |
| dbo:pubchem |
9568512 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Thioacetazone.svg?width=300 |
| dbo:wikiPageExternalLink |
http://www.chemindustry.com/chemicals/013633964.html http://www.spiegel.de/spiegel/print/d-20300776.html |
| dbo:wikiPageID |
4837630 (xsd:integer) |
| dbo:wikiPageLength |
6503 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1106661970 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbc:Anti-tuberculosis_drugs dbr:Blood_plasma dbr:Antibiotic dbr:Rifampicin dbc:Antibiotics dbc:Thioureas dbr:Oral_administration dbr:Thiosemicarbazide dbr:Tuberculosis dbc:Thiosemicarbazone dbr:Ethambutol dbr:British_Approved_Name dbc:Acetanilides dbr:International_Nonproprietary_Name dbr:Isoniazid dbr:Biological_target dbr:Biosynthesis dbr:Toxicity dbr:Mechanism_of_action dbr:United_States_Adopted_Name dbr:Mycobacterium_tuberculosis dbr:Mycolic_acid dbr:Tuberculosis_management |
| dbp:alt |
Space-filling model of thioacetazone (en) Structural formula of thioacetazone (en) |
| dbp:atcPrefix |
J04 (en) |
| dbp:atcSuffix |
AM04 (en) |
| dbp:c |
10 (xsd:integer) |
| dbp:casNumber |
0104-06-03 (xsd:date) |
| dbp:chembl |
375492 (xsd:integer) |
| dbp:chemspiderid |
7843221 (xsd:integer) |
| dbp:h |
12 (xsd:integer) |
| dbp:image |
Thioacetazone 3D spacefill.png (en) |
| dbp:iupacName |
N-{4-[methyl]phenyl}acetamide (en) |
| dbp:kegg |
D08584 (en) |
| dbp:n |
4 (xsd:integer) |
| dbp:o |
1 (xsd:integer) |
| dbp:pubchem |
9568512 (xsd:integer) |
| dbp:routesOfAdministration |
Oral (en) |
| dbp:s |
1 (xsd:integer) |
| dbp:smiles |
O=CC (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
SRVJKTDHMYAMHA-WUXMJOGZSA-N (en) |
| dbp:synonyms |
Thiacetazone; Thiocetazone; Thioparamizone; Benzothiozane; 4-Acetylaminobenzaldehyde thiosemicarbazone; N-[4-[ methyl]phenyl]acetamide (en) |
| dbp:tradename |
Conteben (en) |
| dbp:unii |
MMG78X7SSR (en) |
| dbp:verifiedfields |
changed (en) |
| dbp:verifiedrevid |
470606762 (xsd:integer) |
| dbp:watchedfields |
changed (en) |
| dbp:width |
225 (xsd:integer) 250 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Drugbox dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Ebicite dbt:Fdacite dbt:Keggcite dbt:Stdinchicite dbt:Drugs.com dbt:Antibiotics |
| dcterms:subject |
dbc:Anti-tuberculosis_drugs dbc:Antibiotics dbc:Thioureas dbc:Thiosemicarbazone dbc:Acetanilides |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatAntibiotics yago:Acetanilide102674912 yago:Agent114778436 yago:Analgesic102707683 yago:Antibacterial102716205 yago:Antibiotic102716866 yago:CausalAgent100007347 yago:Drug103247620 yago:Matter100020827 yago:Medicine103740161 yago:PhysicalEntity100001930 dbo:Drug yago:Substance100020090 yago:WikicatAcetanilides |
| rdfs:comment |
Il tiacetazone è un derivato dai sulfamidici contenenti , ma risulta meno tossico e più efficace di questi ultimi. (it) Thioacetazone (INN, BAN), also known as amithiozone (USAN), is an oral antibiotic which is used in the treatment of tuberculosis. It has fallen into almost complete disuse due to toxicity and the introduction of improved anti-tuberculosis drugs like isoniazid. The drug has only weak activity against Mycobacterium tuberculosis and is only useful in preventing resistance to more powerful drugs such as isoniazid and rifampicin. It is never used on its own to treat tuberculosis; it is used in a similar way to ethambutol. (en) |
| rdfs:label |
Tiacetazone (it) Thioacetazone (en) |
| owl:sameAs |
freebase:Thioacetazone yago-res:Thioacetazone wikidata:Thioacetazone dbpedia-it:Thioacetazone dbpedia-sh:Thioacetazone dbpedia-sr:Thioacetazone https://global.dbpedia.org/id/4wwJn |
| prov:wasDerivedFrom |
wikipedia-en:Thioacetazone?oldid=1106661970&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Thioacetazone.svg wiki-commons:Special:FilePath/Thioacetazone_3D_spacefill.png |
| foaf:isPrimaryTopicOf |
wikipedia-en:Thioacetazone |
| is dbo:wikiPageRedirects of |
dbr:Conteben dbr:C10H12N4OS dbr:Amithiozone dbr:Benzothiozane dbr:Thiacetazone dbr:Thiazetazone dbr:Thiocetazone dbr:Thioparamizone |
| is dbo:wikiPageWikiLink of |
dbr:Methaniazide dbr:Methaniazide/thioacetazone dbr:List_of_MeSH_codes_(D02) dbr:Conteben dbr:C10H12N4OS dbr:Fantome_Island_Lock_Hospital_and_Lazaret_Sites dbr:ATC_code_J04 dbr:Tuberculosis_management dbr:List_of_drugs:_Tf–Th dbr:Thiosemicarbazone dbr:Amithiozone dbr:Benzothiozane dbr:Thiacetazone dbr:Thiazetazone dbr:Thiocetazone dbr:Thioparamizone |
| is foaf:primaryTopic of |
wikipedia-en:Thioacetazone |
