| dbo:abstract |
Thioester containing protein 1, often called TEP1 is a key component of the arthropod innate immune system. TEP1 was first identified as a key immunity gene in 2001 through functional studies on Anopheles gambiae mosquitoes. TEP1 is an antimicrobial protein which acts in a system reminiscent of the human complement pathway, which damages the cell membranes of pathogens. Studies have shown that TEP1 is structurally and functionally homologous to the human complement protein C3. TEP1 is now known to be important in the resistance of Anopheles mosquitoes to Plasmodium infection, targeting the malaria parasite during its invasion into the mosquitoes body cavity. Following this discovery insect thioester containing proteins have come under increased scrutiny from the scientific community as possible targets for disease control. TEP1 is coded for by two different alleles TEP1-S and TEP-R which are specific to susceptible and resistant mosquito populations respectively. (en) |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Thioester.png?width=300 |
| dbo:wikiPageExternalLink |
http://baxterlab.yale.edu/research http://www.anopheles-strasbourg.fr/research |
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42325581 (xsd:integer) |
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15589 (xsd:nonNegativeInteger) |
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| dbo:wikiPageWikiLink |
dbr:Endoplasmic_reticulum dbr:Anopheles_gambiae dbr:Antimicrobial_peptides dbc:Insect_immunity dbr:Apicomplexan_life_cycle dbr:Horseshoe_crab dbr:Beta_sheet dbr:Peptide dbr:C3_convertase dbr:Vertebrate dbr:Leucine-rich_repeat dbr:RNA_interference dbc:Immunology dbr:Complement_system dbr:Convergent_Evolution dbr:Melanin dbr:Phagocytosis dbr:Thioester dbr:Genetic_engineering dbr:Conformational_change dbr:Opsonin dbr:Anopheles dbr:Antibody dbr:Malaria dbr:Complement_component_3 dbr:Zymogen dbr:Pattern_recognition_receptor dbr:Toll-like_receptor dbr:CUB_domain dbr:Adaptive_immune_system dbr:Transcription_factors dbr:Alleles dbr:Anaphylatoxin dbr:Alternative_complement_pathway dbr:Glycosylation dbr:Protein_dimer dbr:Positive_feedback dbr:Protease dbr:Hemolymph dbr:Covalent_bond dbr:Hydrolysis dbr:Arthropod dbr:Atomic_mass_unit dbc:Antimicrobial_peptides dbr:Phylogenetics dbr:Plasmodium dbr:Clade dbr:Classical_complement_pathway dbr:Nematode dbr:X-ray_crystallography dbr:Lysis dbr:Vertebrates dbr:Double-stranded_RNA dbr:RNAi dbr:NF-kB dbr:Hemocytes dbr:File:Basic_Schematic_of_LRIM1_and_APL1C_LRR_proteins.png dbr:File:TEP1_Maturation.png dbr:File:Thioester.png dbr:File:Anopheles_gambiae_mosquito_feeding_1354.p_lores.jpg |
| dbp:entrezgene |
2828233 (xsd:integer) |
| dbp:name |
Thioester-containing protein 1 (en) |
| dbp:organism |
Anopheles gambia (en) |
| dbp:refseqprotein |
NP_523578.1 (en) |
| dbp:symbol |
TEP1 (en) |
| dbp:taxid |
7165 (xsd:integer) |
| dbp:uniprot |
B5AZK7 (en) |
| dbp:wikiPageUsesTemplate |
dbt:Infobox_nonhuman_protein dbt:Orphan dbt:Reflist dbt:Short_description |
| dcterms:subject |
dbc:Insect_immunity dbc:Immunology dbc:Antimicrobial_peptides |
| gold:hypernym |
dbr:Component |
| rdf:type |
yago:WikicatAntimicrobialPeptides yago:Abstraction100002137 yago:Amide114724264 yago:Chemical114806838 yago:Compound114818238 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:Peptide114743046 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:MilitaryUnit yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 |
| rdfs:comment |
Thioester containing protein 1, often called TEP1 is a key component of the arthropod innate immune system. TEP1 was first identified as a key immunity gene in 2001 through functional studies on Anopheles gambiae mosquitoes. TEP1 is coded for by two different alleles TEP1-S and TEP-R which are specific to susceptible and resistant mosquito populations respectively. (en) |
| rdfs:label |
Thioester-containing protein 1 (en) |
| owl:sameAs |
freebase:Thioester-containing protein 1 yago-res:Thioester-containing protein 1 wikidata:Thioester-containing protein 1 https://global.dbpedia.org/id/g8ae |
| prov:wasDerivedFrom |
wikipedia-en:Thioester-containing_protein_1?oldid=1119763441&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Anopheles_gambiae_mosquito_feeding_1354.p_lores.jpg wiki-commons:Special:FilePath/Basic_Schematic_of_LRIM1_and_APL1C_LRR_proteins.png wiki-commons:Special:FilePath/TEP1_Maturation.png wiki-commons:Special:FilePath/Thioester.png |
| foaf:isPrimaryTopicOf |
wikipedia-en:Thioester-containing_protein_1 |
| is dbo:wikiPageRedirects of |
dbr:Thioester-Containing_Protein_1 |
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dbr:Thioester-Containing_Protein_1 |
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wikipedia-en:Thioester-containing_protein_1 |
