| dbo:abstract |
Tirbanibulin, vermarktet unter dem Markennamen Klisyri (Almirall), ist ein Arzneistoff zur Behandlung von aktinischer Keratose im Gesicht oder auf der Kopfhaut. Es wirkt als Mitosehemmer. (de) Tirbanibulin, sold under the brand name Klisyri, is a medication for the treatment of actinic keratosis (AKs) on the face or scalp. The most common side effects include local skin reactions, application site pruritus, and application site pain. Tirbanibulin was approved for medical use in the United States in December 2020, and in the European Union in July 2021. The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication. It functions as a mitotic inhibitor by inhibiting tubulin polymerization and Src kinase signaling can be potentially effective in deferring the development of AKs to squamous cell carcinoma in situ. (en) |
| dbo:alternativeName |
Klisyri (en) |
| dbo:casNumber |
897016-82-9 |
| dbo:chEMBL |
571546 |
| dbo:class |
dbr:Microtubule_inhibitor |
| dbo:drugbank |
DB06137 |
| dbo:fdaUniiCode |
4V9848RS5G |
| dbo:kegg |
D11691 |
| dbo:pubchem |
23635314 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Tirbanibulin-line.png?width=300 |
| dbo:wikiPageExternalLink |
https://druginfo.nlm.nih.gov/drugportal/name/tirbanibulin |
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66118142 (xsd:integer) |
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11363 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1103124669 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Tyrosine-protein_kinase_CSK dbr:Indication_(medicine) dbc:Ethers dbr:Committee_for_Medicinal_Products_for_Human_Use dbr:Actinic_keratosis dbr:European_Medicines_Agency dbr:Food_and_Drug_Administration dbc:Morpholines dbc:Pyridines dbc:Amides dbr:Mitotic_inhibitor dbr:Medication dbr:Tubulin dbr:First-in-class_medication dbr:Topical_administration dbr:Microtubule_inhibitor |
| dbp:atcPrefix |
D06 (en) |
| dbp:atcSuffix |
BX03 (en) |
| dbp:c |
26 (xsd:integer) |
| dbp:casNumber |
897016 (xsd:integer) |
| dbp:chembl |
571546 (xsd:integer) |
| dbp:chemspiderid |
24633341 (xsd:integer) |
| dbp:class |
dbr:Microtubule_inhibitor |
| dbp:dailymedid |
Tirbanibulin (en) |
| dbp:drugbank |
DB06137 (en) |
| dbp:h |
29 (xsd:integer) |
| dbp:iupacName |
N-benzyl-2-[5-[4-phenyl]pyridin-2-yl]acetamide (en) |
| dbp:kegg |
D11691 (en) |
| dbp:legalEu |
Rx-only (en) |
| dbp:legalUs |
Rx-only (en) |
| dbp:n |
3 (xsd:integer) |
| dbp:o |
3 (xsd:integer) |
| dbp:pdbLigand |
DN0 (en) |
| dbp:pubchem |
23635314 (xsd:integer) |
| dbp:routesOfAdministration |
dbr:Topical_administration |
| dbp:smiles |
O=CNCc1ccccc1 (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
HUNGUWOZPQBXGX-UHFFFAOYSA-N (en) |
| dbp:synonyms |
KX2-391 (en) |
| dbp:tradename |
Klisyri (en) |
| dbp:unii |
4 (xsd:integer) |
| dbp:width |
300 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Antibiotics_and_chemotherapeutics_for_dermatological_use dbt:Cite_web dbt:Infobox_drug dbt:Portal_bar dbt:Reflist dbt:Short_description dbt:Use_American_English dbt:Use_dmy_dates dbt:ClinicalTrialsGov |
| dct:subject |
dbc:Ethers dbc:Morpholines dbc:Pyridines dbc:Amides |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment |
Tirbanibulin, vermarktet unter dem Markennamen Klisyri (Almirall), ist ein Arzneistoff zur Behandlung von aktinischer Keratose im Gesicht oder auf der Kopfhaut. Es wirkt als Mitosehemmer. (de) Tirbanibulin, sold under the brand name Klisyri, is a medication for the treatment of actinic keratosis (AKs) on the face or scalp. The most common side effects include local skin reactions, application site pruritus, and application site pain. Tirbanibulin was approved for medical use in the United States in December 2020, and in the European Union in July 2021. The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication. (en) |
| rdfs:label |
Tirbanibulin (de) Tirbanibulin (en) |
| owl:sameAs |
wikidata:Tirbanibulin dbpedia-de:Tirbanibulin https://global.dbpedia.org/id/2bh6i |
| prov:wasDerivedFrom |
wikipedia-en:Tirbanibulin?oldid=1103124669&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Tirbanibulin-line.png |
| foaf:isPrimaryTopicOf |
wikipedia-en:Tirbanibulin |
| is dbo:wikiPageRedirects of |
dbr:Klisyri |
| is dbo:wikiPageWikiLink of |
dbr:Actinic_keratosis dbr:ATC_code_D06 dbr:Klisyri |
| is foaf:primaryTopic of |
wikipedia-en:Tirbanibulin |
