Tomatidine (original) (raw)
Tomatidine is an anabolic chemical compound that prevents muscle wasting. It is naturally found in leaves of tomatoes and green tomatoes. Chemically, it is the aglycone of tomatine. It has been shown to have multiple health benefits. Tomatidine is an inhibitor of skeletal muscle atrophy, and a potential therapeutic agent for aging-associated sarcopenia, reducing weakness and atrophy in aged skeletal muscle by interaction with the ATF4 (a critical mediator of age-related muscle weakness and atrophy).
| Property | Value |
|---|---|
| dbo:abstract | Tomatidine is an anabolic chemical compound that prevents muscle wasting. It is naturally found in leaves of tomatoes and green tomatoes. Chemically, it is the aglycone of tomatine. It has been shown to have multiple health benefits. Tomatidine is an inhibitor of skeletal muscle atrophy, and a potential therapeutic agent for aging-associated sarcopenia, reducing weakness and atrophy in aged skeletal muscle by interaction with the ATF4 (a critical mediator of age-related muscle weakness and atrophy). Dietary supplementation with ∼0.04% tomatidine for 10 weeks reduces plasma cholesterol and atherosclerosis in ApoE-deficient mice without evidence of toxicity. (en) |
| dbo:alternativeName | (en) Tomatidin (en) (22S,25S)-5alpha-spirosolan-3beta-ol (en) (3beta,5alpha,22beta,25S)-Spirosolan-3-ol (en) 5alpha-Tomatidan-3beta-ol (en) |
| dbo:iupacName | (1R,2S,4S,5′S,6S,7S,8R,9S,12S,13S,16S,18S)-5′,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2′-piperidine]-16-ol (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Tomatidine.svg?width=300 |
| dbo:wikiPageID | 67699681 (xsd:integer) |
| dbo:wikiPageLength | 6210 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1048429073 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Ursolic_acid dbc:Oxygen_heterocycles dbc:Piperidines dbc:Spiro_compounds dbr:Sarcopenia dbr:C._elegans dbr:Aglycone dbr:Tomatine dbr:Aging dbc:Heterocyclic_compounds_with_5_rings dbr:Osteoporosis dbr:Healthspan dbr:Atherosclerosis dbr:Atrophy dbr:ATF4 dbr:Cholesterol dbr:ApoE dbr:Skeletal_muscle |
| dbp:imagefile | Tomatidine.svg (en) |
| dbp:imagesize | 250 (xsd:integer) |
| dbp:iupacname | -5 (xsd:integer) |
| dbp:othernames | -5 (xsd:integer) 5 (xsd:integer) (en) -Spirosolan-3-ol (en) Tomatidin (en) |
| dbp:wikiPageUsesTemplate | dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Reflist dbt:GHS06 dbt:GHS07 dbt:H-phrases dbt:P-phrases |
| dcterms:subject | dbc:Oxygen_heterocycles dbc:Piperidines dbc:Spiro_compounds dbc:Heterocyclic_compounds_with_5_rings |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 dbo:ChemicalCompound |
| rdfs:comment | Tomatidine is an anabolic chemical compound that prevents muscle wasting. It is naturally found in leaves of tomatoes and green tomatoes. Chemically, it is the aglycone of tomatine. It has been shown to have multiple health benefits. Tomatidine is an inhibitor of skeletal muscle atrophy, and a potential therapeutic agent for aging-associated sarcopenia, reducing weakness and atrophy in aged skeletal muscle by interaction with the ATF4 (a critical mediator of age-related muscle weakness and atrophy). (en) |
| rdfs:label | Tomatidine (en) |
| owl:sameAs | wikidata:Tomatidine https://global.dbpedia.org/id/2Y9WW |
| prov:wasDerivedFrom | wikipedia-en:Tomatidine?oldid=1048429073&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Tomatidine.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Tomatidine |
| is dbo:wikiPageWikiLink of | dbr:List_of_compounds_with_carbon_numbers_25–29 dbr:Solanum_erianthum dbr:Tomatine dbr:FIASMA |
| is foaf:primaryTopic of | wikipedia-en:Tomatidine |
