| dbo:abstract |
Volasertib (también conocido como BI 6727) es una molécula pequeña que inhibe a la proteína serina/treonina quinasa, conocida en inglés como polo-like kinase 1 (PLK1). Este fármaco ha sido desarrollado por Boehringer Ingelheim como agente anticancerígeno. Volasertib, es la segunda molécula de una nueva clase de fármacos derivados de dihidropteridinona. (es) Volasertib (also known as BI 6727) is an experimental small molecule inhibitor of the PLK1 (polo-like kinase 1) protein being developed by Boehringer Ingelheim for use as an anti-cancer agent. Volasertib is the second in a novel class of drugs called derivatives. Volasertib was awarded breakthrough drug status in September 2013 and orphan drug status for acute myeloid leukemia in April 2014. (en) |
| dbo:casNumber |
755038-65-4 |
| dbo:chEMBL |
1233528 |
| dbo:fdaUniiCode |
6EM57086EA |
| dbo:kegg |
D10182 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Volasertib.svg?width=300 |
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31665842 (xsd:integer) |
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15903 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1046023556 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Boehringer_Ingelheim dbc:Experimental_cancer_drugs dbr:Febrile_neutropenia dbr:Acute_myeloid_leukemia dbr:Adenosine_triphosphate dbr:Cytarabine dbr:Taxane dbc:Protein_kinase_inhibitors dbr:Neutropenia dbr:PLK1 dbr:Vinca_alkaloid dbr:Thrombocytopenia dbr:Orphan_drug_status dbr:Anaemia dbr:Breakthrough_drug dbr:Acute_myeloid_leukaemia dbr:Anti-cancer_agent dbr:Dihydropteridinone |
| dbp:c |
34 (xsd:integer) |
| dbp:casNumber |
755038 (xsd:integer) |
| dbp:chembl |
1233528 (xsd:integer) |
| dbp:chemspiderid |
26327706 (xsd:integer) |
| dbp:h |
50 (xsd:integer) |
| dbp:iupacName |
N--4--3-methoxybenzamide (en) |
| dbp:iupharLigand |
7947 (xsd:integer) |
| dbp:kegg |
D10182 (en) |
| dbp:n |
8 (xsd:integer) |
| dbp:o |
3 (xsd:integer) |
| dbp:routesOfAdministration |
Oral and Intravenous (en) |
| dbp:smiles |
CC[C@H]1NCC (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
SXNJFOWDRLKDSF-STROYTFGSA-N (en) |
| dbp:unii |
6 (xsd:integer) |
| dbp:verifiedfields |
changed (en) |
| dbp:verifiedrevid |
470631432 (xsd:integer) |
| dbp:watchedfields |
changed (en) |
| dbp:wikiPageUsesTemplate |
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| dct:subject |
dbc:Experimental_cancer_drugs dbc:Protein_kinase_inhibitors |
| gold:hypernym |
dbr:Inhibitor |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:Agent114778436 yago:Antineoplastic102722458 yago:CausalAgent100007347 yago:CytotoxicDrug103157987 yago:Drug103247620 yago:Inhibitor114724436 yago:Matter100020827 yago:Medicine103740161 yago:PhysicalEntity100001930 dbo:Drug yago:Substance100020090 yago:WikicatExperimentalCancerDrugs yago:WikicatProteinKinaseInhibitors |
| rdfs:comment |
Volasertib (también conocido como BI 6727) es una molécula pequeña que inhibe a la proteína serina/treonina quinasa, conocida en inglés como polo-like kinase 1 (PLK1). Este fármaco ha sido desarrollado por Boehringer Ingelheim como agente anticancerígeno. Volasertib, es la segunda molécula de una nueva clase de fármacos derivados de dihidropteridinona. (es) Volasertib (also known as BI 6727) is an experimental small molecule inhibitor of the PLK1 (polo-like kinase 1) protein being developed by Boehringer Ingelheim for use as an anti-cancer agent. Volasertib is the second in a novel class of drugs called derivatives. Volasertib was awarded breakthrough drug status in September 2013 and orphan drug status for acute myeloid leukemia in April 2014. (en) |
| rdfs:label |
Volasertib (es) Volasertib (en) |
| owl:sameAs |
freebase:Volasertib yago-res:Volasertib wikidata:Volasertib dbpedia-es:Volasertib dbpedia-sh:Volasertib dbpedia-sr:Volasertib https://global.dbpedia.org/id/4xZ6z |
| prov:wasDerivedFrom |
wikipedia-en:Volasertib?oldid=1046023556&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Volasertib.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Volasertib |
| is dbo:wikiPageWikiLink of |
dbr:Boehringer_Ingelheim dbr:PLK1 dbr:List_of_drugs:_Vf–Vz |
| is foaf:primaryTopic of |
wikipedia-en:Volasertib |
