Vpx (original) (raw)
Vpx is a virion-associated protein encoded by human immunodeficiency virus type 2 HIV-2 and most simian immunodeficiency virus (SIV) strains, but that is absent from HIV-1. It is similar in structure to the protein Vpr that is carried by SIV and HIV-2 as well as HIV-1. Vpx is one of five accessory proteins (Vif, Vpx, Vpr, Vpu, and Nef) carried by lentiviruses that enhances viral replication by inhibiting host antiviral factors.
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| dbo:abstract | Vpx is a virion-associated protein encoded by human immunodeficiency virus type 2 HIV-2 and most simian immunodeficiency virus (SIV) strains, but that is absent from HIV-1. It is similar in structure to the protein Vpr that is carried by SIV and HIV-2 as well as HIV-1. Vpx is one of five accessory proteins (Vif, Vpx, Vpr, Vpu, and Nef) carried by lentiviruses that enhances viral replication by inhibiting host antiviral factors. Vpx enhances HIV-2 replication in humans by counteracting the host factor SAMHD1. SAMHD1 is a host factor found in human myeloid cells, such as dendritic cells and macrophages, that restricts HIV-1 replication by depleting the cytoplasmic pool of deoxynucleoside triphosphates needed for viral DNA production. SAMHD1 does not, however, restrict HIV-2 replication in myeloid cells due to the presence of viral Vpx. Vpx counteracts restriction by inducing the ubiquitin-proteasome-dependent degradation of SAMHD1. Vpx-mediated degradation of SAMHD1 therefore decreases deoxynucleoside triphosphate hydrolysis, thereby increasing the availability of dNTPs for viral reverse transcription in the cytoplasm. It has been postulated that SAMHD1 degradation is required for HIV-2 replication because the HIV-2 reverse transcriptase (RT) is less active than the HIV-1 RT, which would be the reason for the absence of Vpx from HIV-1. Because Vpx is required for HIV-2 reverse transcription and the early stages of the viral life cycle, it is packaged into virions in significant amounts. Vpx is also involved in the nuclear import of the HIV-2/SIV genomes and associated proteins, but the specific mechanisms and interactions are currently unknown. Although Vpr and Vpx are similar in size (both are ~100 amino acids with 20-25% sequence similarity) and structure (both are predicted to have similar tertiary structure with three major helices), they serve very different roles in viral replication. Vpx targets a host restriction factor for proteasomal degradation, while Vpr arrests the host cell cycle in the G2 phase. However, they are both involved in the import of the viral preintegration complex into the host nucleus. (en) |
| dbo:wikiPageID | 38874876 (xsd:integer) |
| dbo:wikiPageLength | 5900 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1093374788 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Proteasome dbr:Cytoplasm dbr:DNA dbr:Viral_infectivity_factor dbr:SAMHD1 dbr:Simian_immunodeficiency_virus dbr:Dendritic_cell dbr:Deoxynucleoside_triphosphate dbc:Proteins dbr:Vpu dbr:Lentivirus dbr:HIV-1 dbr:HIV-2 dbc:Viral_regulatory_and_accessory_proteins dbc:Virology dbr:Nef_(protein) dbr:Macrophage dbr:Viral_life_cycle dbr:Vpr dbr:Reverse_transcription dbr:Accessory_protein dbr:Myeloid_cell |
| dbp:organism | Human immunodeficiency virus type 2 subtype A (en) |
| dbp:uniprot | P06939 (en) |
| dbp:wikiPageUsesTemplate | dbt:About dbt:Infobox_nonhuman_protein dbt:Reflist dbt:Viral_proteins |
| dcterms:subject | dbc:Proteins dbc:Viral_regulatory_and_accessory_proteins dbc:Virology |
| gold:hypernym | dbr:Protein |
| rdf:type | yago:WikicatViralProteins yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:Protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatProteins |
| rdfs:comment | Vpx is a virion-associated protein encoded by human immunodeficiency virus type 2 HIV-2 and most simian immunodeficiency virus (SIV) strains, but that is absent from HIV-1. It is similar in structure to the protein Vpr that is carried by SIV and HIV-2 as well as HIV-1. Vpx is one of five accessory proteins (Vif, Vpx, Vpr, Vpu, and Nef) carried by lentiviruses that enhances viral replication by inhibiting host antiviral factors. (en) |
| rdfs:label | Vpx (en) |
| owl:sameAs | freebase:Vpx yago-res:Vpx wikidata:Vpx https://global.dbpedia.org/id/4xGM4 |
| prov:wasDerivedFrom | wikipedia-en:Vpx?oldid=1093374788&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:Vpx |
| is dbo:wikiPageDisambiguates of | dbr:VPX_(disambiguation) |
| is dbo:wikiPageRedirects of | dbr:Vpx_(Viral_Protein) |
| is dbo:wikiPageWikiLink of | dbr:Jonathan_P._Stoye dbr:Lentivirus dbr:CUL4A dbr:CUL4B dbr:VPX_(disambiguation) dbr:Vpr dbr:Vpx_(Viral_Protein) |
| is foaf:primaryTopic of | wikipedia-en:Vpx |