Zoxazolamine (INN, USAN, BAN) (brand name Contrazole, Deflexol, Flexin, Miazol, Uri-Boi, Zoxamine, Zoxine) is a muscle relaxant that is no longer marketed. It was synthesized in 1953 and introduced clinically in 1955 but was withdrawn due to hepatotoxicity. One of its active metabolites, chlorzoxazone, was found to show less toxicity, and was subsequently marketed in place of zoxazolamine. These drugs activate IKCa channels.
| Property |
Value |
| dbo:abstract |
Zoxazolamine (INN, USAN, BAN) (brand name Contrazole, Deflexol, Flexin, Miazol, Uri-Boi, Zoxamine, Zoxine) is a muscle relaxant that is no longer marketed. It was synthesized in 1953 and introduced clinically in 1955 but was withdrawn due to hepatotoxicity. One of its active metabolites, chlorzoxazone, was found to show less toxicity, and was subsequently marketed in place of zoxazolamine. These drugs activate IKCa channels. (en) |
| dbo:casNumber |
61-80-3 |
| dbo:chEBI |
35053 |
| dbo:chEMBL |
472566 |
| dbo:fdaUniiCode |
9DOW362Q29 |
| dbo:kegg |
C13841 |
| dbo:pubchem |
6103 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Zoxazolamine.svg?width=300 |
| dbo:wikiPageID |
45235736 (xsd:integer) |
| dbo:wikiPageLength |
3267 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1001373315 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbc:Amines dbc:Muscle_relaxants dbc:Organochlorides dbr:Oral_administration dbc:Hepatotoxins dbr:Muscle_relaxant dbr:Active_metabolite dbr:British_Approved_Name dbc:Withdrawn_drugs dbr:International_Nonproprietary_Name dbc:Benzoxazoles dbr:Chlorzoxazone dbr:Hepatotoxicity dbr:IK_channel dbr:United_States_Adopted_Name dbr:List_of_withdrawn_drugs |
| dbp:c |
7 (xsd:integer) |
| dbp:casNumber |
61 (xsd:integer) |
| dbp:chebi |
35053 (xsd:integer) |
| dbp:chembl |
472566 (xsd:integer) |
| dbp:chemspiderid |
5878 (xsd:integer) |
| dbp:cl |
1 (xsd:integer) |
| dbp:h |
5 (xsd:integer) |
| dbp:iupacName |
5 (xsd:integer) |
| dbp:kegg |
13841.0 |
| dbp:n |
2 (xsd:integer) |
| dbp:o |
1 (xsd:integer) |
| dbp:pubchem |
6103 (xsd:integer) |
| dbp:routesOfAdministration |
dbr:Oral_administration |
| dbp:smiles |
C1=CC2=CN=CN (en) |
| dbp:stdinchi |
InChI=1S/C7H5ClN2O/c8-4-1-2-6-510-711-6/h1-3H, (en) |
| dbp:stdinchikey |
YGCODSQDUUUKIV-UHFFFAOYSA-N (en) |
| dbp:synonyms |
McN-485 (en) |
| dbp:unii |
9 (xsd:integer) |
| dbp:width |
200 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Drugbox dbt:Musculoskeletal-drug-stub dbt:Reflist dbt:Muscle_relaxants dbt:Ion_channel_modulators |
| dcterms:subject |
dbc:Amines dbc:Muscle_relaxants dbc:Organochlorides dbc:Hepatotoxins dbc:Withdrawn_drugs dbc:Benzoxazoles |
| gold:hypernym |
dbr:Channels |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug dbo:TelevisionStation |
| rdfs:comment |
Zoxazolamine (INN, USAN, BAN) (brand name Contrazole, Deflexol, Flexin, Miazol, Uri-Boi, Zoxamine, Zoxine) is a muscle relaxant that is no longer marketed. It was synthesized in 1953 and introduced clinically in 1955 but was withdrawn due to hepatotoxicity. One of its active metabolites, chlorzoxazone, was found to show less toxicity, and was subsequently marketed in place of zoxazolamine. These drugs activate IKCa channels. (en) |
| rdfs:label |
Zoxazolamine (en) |
| owl:sameAs |
freebase:Zoxazolamine yago-res:Zoxazolamine wikidata:Zoxazolamine dbpedia-vi:Zoxazolamine https://global.dbpedia.org/id/zJ4K |
| prov:wasDerivedFrom |
wikipedia-en:Zoxazolamine?oldid=1001373315&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Zoxazolamine.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Zoxazolamine |
| is dbo:wikiPageWikiLink of |
dbr:List_of_compounds_with_carbon_number_7 dbr:List_of_MeSH_codes_(D03) dbr:Hyperuricemia dbr:Chlorzoxazone dbr:List_of_drugs:_Z |
| is foaf:primaryTopic of |
wikipedia-en:Zoxazolamine |
