Vertical Transmission and Fetal Replication of Nipah Virus in an Experimentally Infected Cat (original) (raw)
Journal Article
1
Commonwealth Scientific and Industrial Research Organisation, Livestock Industries, Australian Animal Health Laboratory
,
Geelong, Victoria, Australia
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1
Commonwealth Scientific and Industrial Research Organisation, Livestock Industries, Australian Animal Health Laboratory
,
Geelong, Victoria, Australia
Search for other works by this author on:
1
Commonwealth Scientific and Industrial Research Organisation, Livestock Industries, Australian Animal Health Laboratory
,
Geelong, Victoria, Australia
Search for other works by this author on:
1
Commonwealth Scientific and Industrial Research Organisation, Livestock Industries, Australian Animal Health Laboratory
,
Geelong, Victoria, Australia
Search for other works by this author on:
1
Commonwealth Scientific and Industrial Research Organisation, Livestock Industries, Australian Animal Health Laboratory
,
Geelong, Victoria, Australia
Search for other works by this author on:
1
Commonwealth Scientific and Industrial Research Organisation, Livestock Industries, Australian Animal Health Laboratory
,
Geelong, Victoria, Australia
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2
Department of Microbiology and Immunology, Uniformed Services University
,
Bethesda, Maryland
Reprints or correspondence: Dr. Christopher C. Broder, Dept. of Microbiology and Immunology, Uniformed Services University, 4301 Jones Bridge Rd., Bethesda, MD 20814 ([email protected]).
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Received:
18 February 2007
Published:
15 September 2007
Cite
Bruce A. Mungall, Deborah Middleton, Gary Crameri, Kim Halpin, John Bingham, Bryan T. Eaton, Christopher C. Broder, Vertical Transmission and Fetal Replication of Nipah Virus in an Experimentally Infected Cat, The Journal of Infectious Diseases, Volume 196, Issue 6, 15 September 2007, Pages 812–816, https://doi.org/10.1086/520818
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Abstract
A female adult cat developed clinical disease 13 days after subcutaneous inoculation with Nipah virus (NiV) and was discovered to be pregnant at necropsy. Viral genome was detected in a variety of specimens, including blood, serum, tonsil swabs, and urine, up to 3 days before the onset of disease. Samples collected postmortem, including placenta, uterine fluid, and fetal tissues, were also positive for NiV genome, and the placenta and uterine fluid contained high levels of recoverable virus. The high levels of viral shedding in the adult combined with fetal viral replication suggests that both vertical and horizontal transmission of NiV could play a role in spillover events, an essential element in the epidemiology of Henipavirus infection.
© 2007 by the Infectious Diseases Society of America
Topic:
- pregnancy
- epidemiology
- adult
- autopsy
- cats
- disease transmission, horizontal
- vertical disease transmission
- fetus
- genome
- viral genome
- vaccination
- virus replication
- virus shedding
- infections
- placenta
- tonsil
- urine
- uterus
- viruses
- nipah virus
- henipavirus
- serum
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