Treatment of liver disease with malotilate. A pharmacokinetic and pharmacodynamic phase II study in cirrhosis (original) (raw)
References
Audétat V, Preisig R, Bircher J (1977) Der Aminopyrin-Atemtest unter akuter Alkoholeinwirkung. Schweiz Med Wochenschr 107: 231–235 Google Scholar
Bailar JC, Louis TA, Lavori PW, Polansky M (1984) Studies without internal controls. N Engl J Med 311: 156–162 Google Scholar
Bircher J (1983) Quantitative assessment of deranged hepatic function: A missed opportunity? Semin Liver Dis 3: 275–284 Google Scholar
Bircher J, Küpfer A, Gikalov J, Preisig R (1976) Aminopyrine demethylation measured by breath analysis in cirrhosis. Clin Pharmacol Ther 20: 484–492 Google Scholar
Blaschke TF, Rubin PC (1979) Hepatic first-pass metabolism in liver disease. Clin Pharmacokinet 4: 423–432 Google Scholar
Boyes RN, Scott DB, Jebson PJ, Godman MJ, Julian DG (1971) Pharmacokinetics of lidocaine in man. Clin Pharmacol Ther 12: 105–116 Google Scholar
Feely J, Wilkinson GR, Wood AJ (1981) Reduction of liver blood flow and propranolol metabolism by cimetidine. N Engl J Med 304: 692–695 Google Scholar
Finch CA, Huebers H (1982) Perspectives in iron metabolism. N Engl J Med 306: 1520–1528 Google Scholar
Frei A, Zimmermann A, Weigand K (1984) The N-terminal propeptide of collagen type III in serum reflects activity and degree of fibrosis in patients with chronic liver disease. Hepatology 4: 830–834 Google Scholar
Fujisawa K, Kimura K, Yamauchi M, Kitahara T, Kawase H, Watanabe Y, Ogura K, Nakajima H, Kameda H (1983) Studies on the lipotropic effect of malotilate on the development of fatty liver induced by orotic acid. In: Oda T, Tygstrup N (eds) Hepatotrophic agent malotilate. Proceedings of a Symposium on Malotilate 1982. Excerpta Medica, Amsterdam. Current Clinical Practise Series No. 10, pp 29–43 Google Scholar
Gibaldi M, Perrier D (1981) Pharmacokinetics, 2nd edn. Marcel Dekker, New York Basel, p 449 Google Scholar
Grandjean EM, Paumgartner G, Preisig R (1979) Die Gallensäurenkonzentration im Serum nach einer Testmahlzeit bei hepatobiliären Erkrankungen. Ein Vergleich mit quantitativen Tests der Leberfunktion. Schweiz Med Wochenschr 109: 1280–1284 Google Scholar
Hahn EG (1984) Blood analysis of liver fibrosis. J Hepatol 1: 67–73 Google Scholar
Huet PM, Villeneuve JP (1983) Determinance of drug disposition in patients with cirrhosis. Hepatology 3: 913–918 Google Scholar
Igarashi S, Hatahara T, Funaki N (1983) Effects of malotilate on protein synthesis in partially hepatectomized normal and cirrhotic rat livers. In: Oda T, Tygstrup N (eds) Hepatotrophic agent malotilate, Proceedings of a Symposium on Malotilate 1982. Excerpta Medica, Amsterdam. Current Clinical Practise Series No. 10, pp 9–20 Google Scholar
Imaizumi Y, Sugimoto T, Kasai T (1981) Effect of diisopropyl 1,3-dithiol-2-ylidenemalonate (NKK-105) of fatty liver induced by carbon tetrachloride. Jpn J Pharmacol 31: 15–21 Google Scholar
Jacobs A, Worwood M (1975) Ferritin in serum, clinical and biochemical implications. N Engl J Med 292: 951–956 Google Scholar
Katoh M, Kitada M, Satoh T, Kitagawa H, Sugimoto T, Kasai T (1981) Further studies on the in vivo effect of diisopropyl 1,3-dithiol-2-ylidenemalonate (NKK-105) on the liver microsomal drug oxidation system in rats. Biochem Pharmacol 30: 2759–2765 Google Scholar
Katoh M, Kitada M, Satoh T, Kitagawa H, Sugimoto T, Kasai T (1980) Effect of diisopropyl 1,3-dithiol-2-ylidenemalonate on microsomal electron transport system in rat liver. J Pharm Dyn 3: 261–263 Google Scholar
Keiding S, Johansen S, Morgensen CE, Solling K (1977) Kinetics of ethanol inhibition of galactose elimination in perfused pig liver. Scand J Clin Lab Invest 34: 487–494 Google Scholar
Kitagawa H (1983) Effects of malotilate on cholesterol metabolism and microsomal electron transport in rat livers. In: Oda T, Tygstrup N (eds) Hepatotrophic agent malotilate. Proceedings of a Symposium on Malotilate 1982. Excerpta Medica, Amsterdam. Current Clinical Practise Series No. 10, pp 21–28 Google Scholar
Monna T (1983) Effect of malotilate on experimental liver fibrosis (cirrhosis) induced by carbon tetrachloride or egg yolk sensitization. In: Oda T, Tygstrup N (eds) Hepatotrophic agent malotilate. Proceedings of a Symposium on Malotilate 1982. Excerpta Medica, Amsterdam. Current Clinical Practise Series No. 10, pp 44–53 Google Scholar
Müller M, Isenschmid M, Bührer M, Bircher J (1984) Automated digital plethysmography in human pharmacology, a methodological study. Arzneimittelforsch/Drug Res 34: 702–706 Google Scholar
Park BK (1982) Assessment of the drug metabolism capacity of the liver. Br J Clin Pharmacol 14: 631–651 Google Scholar
Patwardan RV, Johnson RF, Hoyumpa A, Sheehan JJ, Desmond PV, Wilkinson GR, Branch RA, Schenker S (1981) Normal metabolism of morphine in cirrhosis. Gastroenterology 81: 1006–1011 Google Scholar
Paumgartner G (1975) The handling of indocyanine green by the liver. Schweiz Med Wochenschr 105 [Suppl]: 1–30 Google Scholar
Paumgartner G, Vasella DL, Herz E, Reichen J, Preisig R (1979) Hepatische Extraktion von Taurocholat und Indocyaningrün bei Patienten mit Lebererkrankungen. Z Gastroenterol 17: 753–761 Google Scholar
Pauwels S, Geubel AP, Dive C, Beckers C (1982) Breath14CO2 after intravenous administration of (14C) aminopyrine in liver diseases. Dig Dis Sci 27: 49–56 Google Scholar
Pentikainen PJ, Neuvonen PJ, Tarpila S, Syvalahti E (1978) Effect of cirrhosis of the liver on the pharmacokinetics of chlormethiazole. Br Med J 2: 861–863 Google Scholar
Porchet H, Bircher J (1982) Noninvasive assessment of portal-systemic shunting: evaluation of a method to investigate systemic availability of oral glyceryl trinitrate by digital plethysmography. Gastroenterology 82: 629–637 Google Scholar
Rojkind M, Kershenobich D (1983) Liver fibrosis, a dynamic process? In: Csomos G, Thaler H (eds) Clinical hepatology. Springer, Berlin Heidelberg New York Google Scholar
Sachs L (1978) Angewandte Statistik, 5th edn. Springer, Berlin Heidelberg New York Google Scholar
Shull HJ, Wilkinson GR, Johnson R (1976) Normal disposition of oxazepam in acute viral hepatitis and cirrhosis. Ann Intern Med 84: 420–425 Google Scholar
Sugimoto T (1983) Malotilate, an overview. In: Oda T, Tygstrup N (eds) Hepatotrophic agent malotilate. Proceedings of a Symposium on Malotilate 1982. Excerpta Medica, Amsterdam. Current Clinical Practise Series No. 10, pp 1–8 Google Scholar
Suzuki H, Ichida F, Takino T, Nagashima H, Hirayama C, Fujisawa K, Furuta S, Monna T, Yamamoto S, Oda T (1983) Therapeutic effects of malotilate on chronic hepatitis and liver cirrhosis: A double-blind, controlled multicenter trial. In: Oda T, Tygstrup N (eds) Hepatotrophic agent malotilate. Proceedings of a Symposium on Malotilate 1982. Excerpta Medica, Amsterdam. Current Clinical Practise Series No. 10, pp 54–68 Google Scholar
Tygstrup N (1966) Determination of the hepatic elimination capacity (Lm) of galactose by single injection. Scand J Clin Lab Invest 18 [Suppl 92]: 118–125 Google Scholar
Weigand K, Zaugg PY, Frei A, Zimmermann A (1984) Long term follow-up of the N-terminal propeptide of collagen type III in serum of patients with chronic liver disease. Hepatology 4: 835–838 Google Scholar