Neurotensin peptides antagonistically regulate postsynaptic dopamine D2 receptors in rat nucleus accumbens: a receptor binding and microdialysis study (original) (raw)
References
Agnati LF, Fuxe K, Benfenati F, Battistini N, Härfstrand A, Hökfelt T, Cavicchioli L, Tatemoto K, Mutt V (1983) Neurotensin in vitro markedly reduces the affinity in subcortical limbic [3H]N-propylnorapomorphine binding sites. Acta Physiol Scand 119: 459–461 PubMed Google Scholar
Checler F, Vincent JP, Kitabgi P (1983) Degradation of neurotensin by rat brain synaptic membranes. Involvement of a thermolusin-like metalloendopeptidase (enkephalinase), angiotensin-converting enzyme and other unidentified peptidases. J Neurochem 41: 375–381 PubMed Google Scholar
Checler F, Barelli H, Kitabgi P, Vincent JP (1988) Neurotensin metabolism in various tissues of central and peripheral origins: ubiquitious involvement of a novel neurotensin degrading metalloendopeptidase. Biochimie 70: 75–81 PubMed Google Scholar
Coquerel A, Dubuc I, Kitabgi P, Costentin J (1988) Potentiation by thiorphan and bestatin of the naloxone-insensitive analgesic effects of neurotensin and neuromedin N. Neurochem Int 12: 361–366 Google Scholar
Creese I, Padgett L, Fazzini E, Lopez F (1979) [3H]N-propylnorapomorphine: a novel agonist for central dopamine receptors. Eur J Pharmacol 56: 411–412 PubMed Google Scholar
Dobner PR, Barbeer DL, Villa-Komaroff L, MoKiernan C (1987) Cloning and sequence analysis of cDNA for the canine neurotensin/neuromedin N precursor. Proc Natl Acad Sci USA 84: 3516–3520 PubMed Google Scholar
Dubuc I, Nouelö D, Coquerel A, Menard JF, Kitabgi P, Costentin J (1988) Hypothermic effect of neuromedin N in mice and its potentiation by peptidase inhibitors. Eur J Pharmacol 151: 117–121 PubMed Google Scholar
Fuxe K, Agnati L, von Euler G, Benfenati F, Tanganelli S (1990) Modulation of dopamine D1 and D2 transmission lines in the central nervous system. In: Osborne N (ed) Current aspects in the neurosciences, vol 1. MacMillan Press, Basingstoke, pp 203–243 Google Scholar
Fuxe K, von Euler G, Agnati LF, Merlo Pich E, O'Connor WT, Tanganelli S, Li XM, Tinner B, Cintra A, Carani C, Benfenati F (1992a) Intramembrane interactions between neurotensin receptors and dopamine D2 receptors as a major mechanism for the neuroleptic-like action of neurotensin. Ann NY Acad Sci 668: 186–204 PubMed Google Scholar
Fuxe K, O'Connor WT, Antonelli T, Osborne PG, Tanganelli S, Agnati LF, Ungerstedt U (1992b) Evidence for a substrate of neuronal plasticity based on pre- and postsynaptic neurotensin-dopamine receptor interactions in the neostriatum. Proc Natl Acad Sci USA 89: 5591–5595 PubMed Google Scholar
Granier C, Van Rietschoten J, Kitabgi P, Poustis C, Freychet P (1982) Synthesis and characterization of neurotensin analogus for structure/activity relationship studies. Eur J Biochem 124: 117–123 PubMed Google Scholar
Hedlund P, von Euler G, Fuxe K (1991) Activation of 5-hydroxytryptamine1A receptors increases the affinity of galanin receptors in di- and telencephalic areas of the rat. Brain Res 560: 251–259 PubMed Google Scholar
Kalivas PW, Richardson-Carlson P, Duffy P (1986) Neuromedin N mimics the actions of neurotensin in the ventral tegmental area but not in the nucleus accumbens. J Pharmacol Exp Ther 238: 1126–1131 PubMed Google Scholar
Kehr J, Ungerstedt U (1989) Fast estimation of GABA in microdialysis perfusates: effects of nipecotic acid and 3-mercapto-propionic acid. J Neurochem 51: 1309–1310 Google Scholar
Kislauskia E, Bullock B, MoNeil S, Dobner PR (1988) The rat gene encoding neurotensin and neuromedin N: structure tissue-specific expression, and evolution of exon sequences. J Biol Chem 263: 4963–4968 PubMed Google Scholar
Kitabgi P, de Nadai F, Cuber JC, Duduc I, Nouel D, Costentin J (1990) Calciumdependent release of neurotensin and neuromedin N from mouse hypothalamus. Neuropeptides 15: 111–114 PubMed Google Scholar
Köhler C, Hall H, Ögren SO, Gawell L (1985) Specific in vitro and in vivo binding of [3H]raclopride: a potent substituted benzamine drug with high affinity for dopamine D2 receptors in the rat brain. Biochem Pharmacol 34: 2251–2259 PubMed Google Scholar
Li X-M, Finnman U-B, von Euler G, Hedlund PB, Fuxe K (1993a) Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes. Neurosci Lett 155: 121–124 PubMed Google Scholar
Li X-M, von Euler G, Hedlund PB, Finnman U-B, Fuxe K (1993b) The C-terminal neurotensin-(8-13) fragment potently modulates rat neostriatal dopamine D2 receptors. Eur J Pharmacol 234: 125–128 PubMed Google Scholar
Li X-M, Hedlund PB, Fuxe K (1994a) Strong effects of NT/NN peptides on DA D2 receptors in rat neostriatal sections. NeuroReport 5: 1621–1624 PubMed Google Scholar
Li X-M, Hedlund PB, Agnati LF, Fuxe K (1994b) Dopamine D1 receptors are involved in the modulation of D2 receptors induced by cholecystokinin receptor subtypes in rat neostriatal membranes. Brain Res 680: 289–298 Google Scholar
Li X-M, Hedlund PB, Fuxe K (1994c) Cholecystokinin octapeptide in vitro and in vivo strongly modulates striatal dopamine D2 receptors in sections of rat basal ganglia. Eur J Neurosci (in press)
Minamino N, Kangawa K, Matsuo H (1984) Neuromedin N: a novel neurotensin-like peptide identified in porcine spinal cord. Biochem Biophys Res Commun 122: 542–549 PubMed Google Scholar
Morari M, O'Connor WT, Ungerstedt U, Fuxe K (1993) N-Methyl-D-Aspartic acid differentially regulates extracellular dopamine, GABA, and glutamate levels in the dorsolateral neostriatum of the halothane-anaesthetized rat: an in vivo microdialysis study. J Neurochem 60: 1884–1893 PubMed Google Scholar
Motulsky HJ, Ransnas LA (1987) Fitting curves to data using nonlinear regression: a practical and nonmathematical review. FASEB J 1: 365–374 PubMed Google Scholar
Murthy KS, Grider JR, Makhlouf GM (1992) Receptor-coupled G-proteins mediate contraction and calcium mobilization in isolated intestinal muscle cells. J Pharmacol Exp Ther 260: 90–97 PubMed Google Scholar
O'Connor WT, Fuxe K, Antonelli T, Osborne PG, Tanganelli S, Agnati LF, Ungerstedt U (1991) Dopamine-neurotensin interactions in the neostriatum: evidence for a substrate of neuronal plasticity. PINS 1: 13–17 Google Scholar
O'Connor WT, Tanganelli S, Ungerstedt U, Fuxe K (1992) The effects of neurotensin on GABA and acetylcholine release in the dorsal striatum of the rat: an in vivo microdialysis study. Brain Res 573: 209–216 PubMed Google Scholar
Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. Academic Press, Sidney Google Scholar
Quirion R, Chiueh CC, Heverist HD, Pert A (1985) Comparative localization of neurotensin receptors on nigrostriatal and mesolimbic dopaminergic terminals. Brain Res 327: 385–389 PubMed Google Scholar
Snedecor GW, Cochran WC (1980) Statistical methods. Iowa State University, Ames, pp 291–292 Google Scholar
Tanaka K, Masu M, Nakanishi S (1990) Structure and functional expression of the cloned rat neurotensin receptors. Neuron 4: 847–853 PubMed Google Scholar
Tanganelli S, von Euler G, Fuxe K, Agnati LF, Ungerstedt U (1989) Neurotensin counteracts apomorphine-induced inhibition of dopamine release as studied by microdialysis in rat neostriatum. Brain Res 502: 319–325 PubMed Google Scholar
Tanganelli S, O'Connor WT, Ferraro J, Bianchi C, Beani L, Ungerstedt U, Fuxe K (1994) Facilitation of GABA release by neurotensin is associated with a reduction of dopamine release in rat nucleus accumbens. Neuroscience 60: 649–657 PubMed Google Scholar
Ungerstedt U (1984) Measurement of neurotransmitter release by intracranial dialysis. In: Marsden CD (ed) Measurement of neurotransmitter release in vitro. Wiley, New York, pp 81–105 Google Scholar
Ungerstedt U (1991) Introduction to intracerebral microdialysis. In: Robinson TE, et al (eds) Microdialysis in the neurosciences. Techniques in the behavioural and neurosciences III. Elsevier, New York, pp 3–18 Google Scholar
von Euler G (1991) Biochemical characterization of the intramembrane interaction between neurotensin and dopamine D2 receptors in the rat brain. Brain Res 561: 93–98 PubMed Google Scholar
von Euler G, van der Ploeg I, Fredholm BB, Fuxe K (1991) Neurotensin decreases the affinity of dopamine D2 agonist binding by a G-protein-independent mechanism. J Neurochem 56: 178–183 PubMed Google Scholar
Winer BJ (1971) Satistical priciples in experimental design. McGraw-Hill, New York Google Scholar
Zoli M, Agnati LF, Hedlund PB, Li X-M, Ferre S, Fuxe K (1993) Receptor-receptor interactions as an integrative mechanism in nerve cells. Mol Neurobiol 7: 293–334 PubMed Google Scholar