Cariprazine, a dopamine D3-receptor-preferring partial agonist, blocks phencyclidine-induced impairments of working memory, attention set-shifting, and recognition memory in the mouse (original) (raw)
Beraki S, Diaz-Heijtz R, Tai F, Ogren SO (2009) Effect of repeated treatment of phencyclidine on cognition and gene expression in C57Bl/6 mice. Int J Neuropsychopharmacol 12:243–255 ArticlePubMedCAS Google Scholar
Birrel JM, Brown VJ (2000) Medial frontal cortex mediates perceptual attention set shifting in the rat. J Neurosci 20:4320–4324 Google Scholar
Bombin I, Arango C, Mayoral M, Castro-Fornieles J, Gonzales-Pinto A, Gonzales-Gomez C, Moreno D, Parellada M, Beaza I, Graell M, Ptero S, Saiz PA, Patiño-Garcia A (2008) DRD3, but not COMT or DRD2, genotype affects executive functions in healthy and first-episode psychosis adolescents. Am J Med Genet B Neuropsychiatr Genet 147B:873–879 ArticlePubMed Google Scholar
Carrión R, Goldberg TE, McLaughlin D, Auther AM, Correll CU, Cornblatt BA (2011) Impact of neurocognition on social and role functioning in individuals at clinical high risk for psychosis. Am J Psychiat 168:806–813 ArticlePubMed Google Scholar
DeSteno DA, Schmauss C (2009) A role for dopamine D2 receptors in reversal learning. Neuroscience 162:118–127 ArticleCAS Google Scholar
Egerton A, Reid L, McKerchar CE, Morris BJ, Pratt JA (2005) Impairment in perceptual atttentional set-shifting following PCP administration: a rodent model of set-shifting deficits. Psychopharmacology 179:77–84 ArticlePubMedCAS Google Scholar
Engelmann M, Wotjak CT, Landgraf R (1995) Social discrimination procedure: an alternative method to investigate juvenile recognition abilities in rats. Physiol Behav 58:315–321 ArticlePubMedCAS Google Scholar
Erlenmeyer-Kimling L, Rock D, Roberts SA, Jamal M, Kestenbaum C, Cornblatt B, Adamo UH, Gottesman II (2000) Attention, memory, and motor skills as childhood predictors of schizophrenia-related psychosis: the New York High Risk Project. Am J Psychiatr 157:1416–1422 ArticlePubMedCAS Google Scholar
Glickstein SB, Hof PR, Schmauss C (2002) Mice lacking dopamine D2 and D3 receptors have spatial working memory deficits. J Neurosci 22:5619–5629 PubMedCAS Google Scholar
Glickstein SB, DeSteno DA, Hof PR, Schmauss C (2005) Mice lacking dopamine D2 and D3 receptors exhibit differential activation of prefrontal cortical neurons during task requiring attention. Cereb Cortex 15:1016–1024 ArticlePubMed Google Scholar
Gottesman II, Erlenmeyer-Kimling L (2001) Family and twin strategies as a head start in defining prodromes and endophenotypes for hypothetical early interventions in schizophrenia. Schizophr Res 51:93–102 ArticlePubMedCAS Google Scholar
Green ME (1996) What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatr 153:321–330 PubMedCAS Google Scholar
Gyertyán I, Kiss B, Sághy K, Laszy J, Szabó G, Szabados T, Gémesi LI, Pásztor G, Zájer-Balázs M, Kapás A, Csongor EA, Domány G, Tihanyi SZ (2011) Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents. Neurochem Int 59:925–935 ArticlePubMed Google Scholar
Hagiwara H, Fujita Y, Ishima T, Kunitachi S, Shirayama Y, Iyo A, Hashimoto K (2008) Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT1A receptors. Eur Neuropsychopharmacol 18:448–454 ArticlePubMedCAS Google Scholar
Hashimoto K, Fujita Y, Shimizu E, Iyo M (2005) Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of clozapine, but not haloperidol. Eur J Pharmacol 519:114–117 ArticlePubMedCAS Google Scholar
Javitt DC, Zukin SR (1991) Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatr 148:1301–1308 PubMedCAS Google Scholar
Jentsch JD, Anzivino LA (2004) A low dose of the alpha2 agonist clonidine ameliorates the visual attention and spatial working memory deficits produced by phencyclidine administration to rats. Psychopharmacology 175:76–83 ArticlePubMedCAS Google Scholar
Jentsch JD, Tran A, Taylor JR, Roth RH (1998) Prefrontal cortical involvement in phencyclidine-induced activation of the mesolimbic dopamine system: behavioral and neurochemical evidence. Psychopharmacology 138:89–95 ArticlePubMedCAS Google Scholar
Jentsch JD, Sanchez D, Elsworth JD, Roth RH (2008) Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoreceptor subtype. Brain Res 1246:41–46 ArticlePubMedCAS Google Scholar
Jung M-Y, Skryabin BV, Arai M, Abbondanzo S, Fu D, Robakis NK, Brosius J, Polites HG, Pintar JE, Schmauss C (1999) Potentiation of the D2-mutant motor phenotype in mice lacking dopamine D2 and D3 receptors. Neuroscience 91:911–924 ArticlePubMedCAS Google Scholar
Kiss B, Horváth A, Némethy Z, Schmidt E, Laszlovszky I, Bugovics G, Fazekas K, Hornok K, Orosz S, Gyertyán I, Agai-Csongor E, Domány G, Tihanyi K, Adham N, Szombathelyi Z (2010) Cariprazine (RGH-188), a dopamine D3 receptor-preferring, D3/D2 dopamine receptor antagonist–partial agonist antipsychotic candidate: in vitro and neurochemical profile. J Pharmacol Exp Ther 333:328–340 ArticlePubMedCAS Google Scholar
Loiseau F, Milan MJ (2009) Blockade of dopamine D3 receptors in frontal cortex, but not in sub-cortical structures, enhances social recognition in rats: similar actions of D1 receptor agonists, but not D2-receptor antagonists. Neuropsychopharmacology 19:23–33 ArticleCAS Google Scholar
Lumme V, Aalto S, Ilonen T, Någren K, Hietala J (2007) Dopamine D2/D3 receptor binding in the anterior cingulate cortex and executive functioning. Psychiatr Res 156:69–74 ArticleCAS Google Scholar
Mailman RB, Murthy V (2010) Third generation antipsychotic drugs: partial agonism or receptor functional selectivity? Curr Pharm Des 16:488–501 ArticlePubMedCAS Google Scholar
Markowitz JS, Brown CS, Moore TR (1999) Atypical antipsychotics. Part I: pharmacology, pharmacokinetics, and efficacy. Ann Pharmacother 33:73–85 ArticlePubMedCAS Google Scholar
Marrs W, Kuperman J, Avedian T, Roth RH, Jentsch JD (2005) Alpha-2 adrenoreceptor activation inhibits phencyclidine-induced deficits of spatial working memory in rats. Neuropsychopharmacology 30:1500–1510 ArticlePubMedCAS Google Scholar
Mehta M, Schmauss C (2011) Strain-specific cognitive deficits in adult mice exposed to early life stress. Behav Neurosci 125:29–36 ArticlePubMed Google Scholar
Nagai T, Murai R, Matsui K, Kamei H, Noda Y, Furukawa H, Nabeshima T (2009) Aripiprazole ameliorates phencyclidine-induced impairment of recognition memory through dopamine D1 and serotonin 5-HT1A receptors. Psychopharmacology 202:315–328 ArticlePubMedCAS Google Scholar
Nuechterlein KH, Barch DM, Gold JM, Goldberg JM, Green MF, Heaton RK (2004) Identification of separable cognitive factors in schizophrenia. Schizophr Res 15:29–39 Article Google Scholar
Park S, Holzman PS (1992) Schizophrenics show spatial working memory deficits. Arch Gen Psychiatr 49:975–982 ArticlePubMedCAS Google Scholar
Pratt JA, Winchester C, Egerton A, Cochran SM, Morris BJ (2008) Modeling prefrontal cortex deficits in schiziphrenia: implications for treatment. Br J Pharmacol 153:5465–5470 Google Scholar
Seneca N, Finnema SJ, Laszlovszky I, Kiss B, Horváth A, Pásztor G, Kapás M, Gyertyán FS, Innis RB, Halldin C, Gulyás B (2011) Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography. Psychopharmacology (Berlin) 218:579–587 ArticleCAS Google Scholar
Sokoloff P, Giros B, Martres MP, Bouthenet ML, Schwartz JC (1990) Molecular cloning and characterization of a novel dopamine receptor D3 as a target for neuroleptics. Nature 347:146–151 ArticlePubMedCAS Google Scholar
Thomas GJ, Brito GN (1980) Recovery of delayed alternation in rats after lesions in medial frontal cortex and septum. J Comp Physiol Psychol 94:808–818 ArticlePubMedCAS Google Scholar
Verma A, Moghaddam B (1996) NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: modulation by dopamine. J Neurosci 16:373–379 PubMedCAS Google Scholar
Watson DJ, Marsden CA, Millan MJ, Fone KC (2012) Blockade of dopamine D3 but not D2 receptor reverses the novel object discrimination impairment produced by post-weaning social isolation: implications for schizophrenia and its treatment. Int J Neuropsychopharmacol 37:770–786 ArticleCAS Google Scholar
Zihl J, Gron G, Brunnauer A (1998) Cognitive deficits in schizophrenia and affective disorders: evidence for a final common pathway disorder. Acta Psychiatr Scand 97:351–357 ArticlePubMedCAS Google Scholar