Endothelium, inflammation, and diabetes (original) (raw)

• Mombouli JV, Vanhoutte PM: Endothelial dysfunction: from physiology to therapy. J Mol Cell Cardiol 1999, 31:61–74.
  Article PubMed CAS Google Scholar
• Sachais BS: Platelet-endothelial interactions in atherosclerosis. Curr Atheroscler Rep 2001, 3:412–416.
  PubMed CAS Google Scholar
• Berk BC, Abe JI, Min W, et al.: Endothelial atheroprotective and anti-inflammatory mechanisms. Ann N Y Acad Sci 2001, 947:93–109; discussion 109–111.
  Article PubMed CAS Google Scholar
• Baron AD: Vascular reactivity. Am J Cardiol 1999, 84:25J-27J.
  Article PubMed CAS Google Scholar
• Taylor AA: Pathophysiology of hypertension and endothelial dysfunction in patients with diabetes mellitus. Endocrinol Metab Clin North Am 2001, 30:983–997.
  Article PubMed CAS Google Scholar
• Ross R: Atherosclerosis—an inflammatory disease. N Engl J Med 1999, 340:115–126.
  Article PubMed CAS Google Scholar
• Faruqi RM, DiCorleto PE: Mechanisms of monocyte recruitment and accumulation. Br Heart J 1993, 69(suppl 1):S19-S29.
  PubMed CAS Google Scholar
• Segrest JP, Anantharamaiah GM: Pathogenesis of atherosclerosis. Curr Opin Cardiol 1994, 9:404–410.
  Article PubMed CAS Google Scholar
• DiCorleto PE: Cellular mechanisms of atherogenesis. Am J Hypertens 1993, 6(11 Pt 2):314S-318S.
  PubMed CAS Google Scholar
• Yla-Herttuala S: Biochemistry of the arterial wall in developing atherosclerosis. Ann N Y Acad Sci 1991, 623:40–59.
  Article PubMed CAS Google Scholar
• Plenz G, Robenek H: Monocytes/macrophages in atherosclerosis. Eur Cytokine Netw 1998, 9:701–703.
  PubMed CAS Google Scholar
• Stary HC, Chandler AB, Dinsmore RE, et al.: A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 1995, 92:1355–1374.
  PubMed CAS Google Scholar
• Itabe H, Takano T: Oxidized low density lipoprotein: the occurrence and metabolism in circulation and in foam cells. J Atheroscler Thromb 2000, 7:123–131.
  PubMed CAS Google Scholar
• Kruth HS: Macrophage foam cells and atherosclerosis. Front Biosci 2001, 6:D429-D55.
  Article PubMed CAS Google Scholar
• deWinther MP, van Dijk KW, Havekes LM, Hofker MH: Macrophage scavenger receptor class A: a multifunctional receptor in atherosclerosis. Arterioscler Thromb Vasc Biol 2000, 20:290–297.
  PubMed Google Scholar
• de Villiers WJ, Smart EJ: Macrophage scavenger receptors and foam cell formation. J Leukoc Biol 1999, 66:740–746.
  PubMed Google Scholar
• Petersen LC, Freskgard P, Ezban M: Tissue factor-dependent factor VIIa signaling. Trends Cardiovasc Med 2000, 10:47–52.
  Article PubMed CAS Google Scholar
• Rauch U, Nemerson Y: Circulating tissue factor and thrombosis. Curr Opin Hematol 2000, 7:273–277.
  Article PubMed CAS Google Scholar
• Barnes PJ, Karin M: Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997, 336:1066–1071.
  Article PubMed CAS Google Scholar
• De Martin R, Hoeth M, Hofer-Warbinek R, Schmid JA: The transcription factor NF-kappa B and the regulation of vascular cell function. Arterioscler Thromb Vasc Biol 2000, 20:E83-E88.
  PubMed Google Scholar
• Neurath MF, Becker C, Barbulescu K: Role of NF-kappaB in immune and inflammatory responses in the gut. Gut 1998, 43:856–860.
  Article PubMed CAS Google Scholar
• Baeuerle PA, Baltimore D: NF-kappa B: ten years after. Cell 1996, 87:13–20.
  Article PubMed CAS Google Scholar
• Woessner JFJr: Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 1991, 5:2145–2154.
  PubMed CAS Google Scholar
• Yan SF, Zou YS, Gao Y, et al.: Tissue factor transcription driven by Egr-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia. Proc Natl Acad Sci U S A 1998, 95:8298–8303.
  Article PubMed CAS Google Scholar
• Yan SF, Pinsky DJ, Mackman N, Stern DM: Egr-1: is it always immediate and early? J Clin Invest 2000, 105:553–554.
  Article PubMed CAS Google Scholar
• Liu C, Yao J, Mercola D, Adamson E: The transcription factor EGR-1 directly transactivates the fibronectin gene and enhances attachment of human glioblastoma cell line U251. J Biol Chem 2000, 275:20315–20323.
  Article PubMed CAS Google Scholar
• Galis ZS, Sukhova GK, Lark MW, Libby P: Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest 1994, 94:2493–2503.
  PubMed CAS Google Scholar
• Falk E, Shah PK, Fuster V: Coronary plaque disruption. Circulation 1995, 92:657–671.
  PubMed CAS Google Scholar
• Southgate KM, Fisher M, Banning AP, et al.: Upregulation of basement membrane-degrading metalloproteinase secretion after balloon injury of pig carotid arteries. Circ Res 1996, 79:1177–1187.
  PubMed CAS Google Scholar
• Aljada A, Ghanim H, Saadeh R, Dandona P: Insulin inhibits NFkappaB and MCP-1 expression in human aortic endothelial cells. J Clin Endocrinol Metab 2001, 86:450–453.
  Article PubMed CAS Google Scholar
• Dandona P, Aljada A, Mohanty P, et al.: Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an antiinflammatory effect? J Clin Endocrinol Metab 2001, 86:3257–3265.
  Article PubMed CAS Google Scholar
• Ghanim H, Mohanty P, Aljada A, et al.: Insulin reduces the pro-inflammatory transcription factor, activation protein-1 (AP-1), in mononuclear cells (MNC) and plasma matrix metalloproteinase-9 (MMP-9) concentration. Diabetes 2001, 50(suppl 2):A408.
  Google Scholar
• Aljada A, Ghanim H, Mohanty P, et al.: Insulin inhibits the pro-inflammatory transcription factor early growth response-1 (Egr-1) expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations. J Clin Endocrinol Metab 2002, 87:1419–1422. Provides further evidence that insulin has an anti-inflammatory effect, including the inhibition of tissue factor and PAI-1 expression. These effects suggest a potential beneficial effect of insulin in thrombin formation and fibrinolysis in atherothrombosis.
  Article PubMed CAS Google Scholar
• Mohanty P, Hamouda W, Garg R, et al.: Glucose challenge stimulates reactive oxygen species (ROS) generation by leucocytes. J Clin Endocrinol Metab 2000, 85:2970–2973.
  Article PubMed CAS Google Scholar
• Aljada A, Ghanim H, Mohanty P, et al.: Glucose intake stimulates intranuclear NFkB and p47phox in mononuclear cells. ENDO 2000, the 82nd Annual Meeting of the Endocrine Society, Toronto, Canada, 2000.
• Aljada A, Ghanim H, Mohanty P, et al.: Glucose intake induces an increase in AP-1 and Egr-1 in mononuclear cells and plasma matrix metalloproteinases and tissue factor concentrations. Diabetes 2002, 51(suppl):A399.
  Google Scholar
• Dandona P, Mohanty P, Ghanim H, et al.: The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation. J Clin Endocrinol Metab 2001, 86:355–362. Demonstrated an increase in ROS-induced damage in lipids, proteins, and amino acids in the obese compared with normal subjects. Also showed a decrease in ROS generation by leukocytes and oxidative damage to lipids, proteins, and amino acids after dietary restriction and weight loss in the obese over a short period.
  Article PubMed CAS Google Scholar
• Dandona P, Thusu K, Cook S, et al.: Oxidative damage to DNA in diabetes mellitus. Lancet 1996, 347:444–445.
  Article PubMed CAS Google Scholar
• Mohanty P, Khurana U, Chaudhuri A, et al.: Non-suppressibility of reactive oxygen species (ROS) generation by mononuclear cells (MNC) in obesity. Diabetes 1996, 45(suppl 1):171A.
  Google Scholar
• Dominguez C, Ruiz E, Gussinye M, Carrascosa A: Oxidative stress at onset and in early stages of type 1 diabetes in children and adolescents. Diabetes Care 1998, 21:1736–1742.
  Article PubMed CAS Google Scholar
• Tesfamariam B: Free radicals in diabetic endothelial cell dysfunction. Free Radic Biol Med 1994, 16:383–391.
  Article PubMed CAS Google Scholar
• Lipinski B: Pathophysiology of oxidative stress in diabetes mellitus. J Diabetes Complications 2001, 15:203–210.
  Article PubMed CAS Google Scholar
• Baynes JW: Role of oxidative stress in development of complications in diabetes. Diabetes 1991, 40:405–412.
  Article PubMed CAS Google Scholar
• Malmberg K, Ryden L, Hamsten A, et al.: Mortality prediction in diabetic patients with myocardial infarction: experiences from the DIGAMI study. Cardiovasc Res 1997, 34:248–253.
  Article PubMed CAS Google Scholar
• Diaz R, Paolasso EA, Piegas LS, et al.: Metabolic modulation of acute myocardial infarction. The ECLA (Estudios Cardiologicos Latinoamerica) Collaborative Group. Circulation 1998, 98:2227–2234.
  PubMed CAS Google Scholar
• Aljada A, Saadeh R, Assian E, et al.: Insulin inhibits the expression of intercellular adhesion molecule-1 by human aortic endothelial cells through stimulation of nitric oxide. J Clin Endocrinol Metab 2000, 85:2572–2575.
  Article PubMed CAS Google Scholar
• Katoh M, Egashira K, Mitsui T, et al.: Angiotensin-converting enzyme inhibitor prevents plasminogen activator inhibitor-1 expression in a rat model with cardiovascular remodeling induced by chronic inhibition of nitric oxide synthesis. J Mol Cell Cardiol 2000, 32:73–83.
  Article PubMed CAS Google Scholar
• Van den Berghe G, Wouters P, Weekers F, et al.: Intensive insulin therapy in critically ill patients. N Engl J Med 2001, 345:1359–1367.
  Article PubMed Google Scholar
• Garg R, Kumbkarni Y, Aljada A, et al.: Troglitazone reduces reactive oxygen species generation by leukocytes and lipid peroxidation and improves flow-mediated vasodilatation in obese subjects. Hypertension 2000, 36:430–435.
  PubMed CAS Google Scholar
• Ghanim H, Garg R, Aljada A, et al.: Suppression of nuclear factor-kappaB and stimulation of inhibitor kappaB by troglitazone: evidence for an anti-inflammatory effect and a potential anti-atherosclerotic effect in the obese. J Clin Endocrinol Metab 2001, 86:1306–1312.
  Article PubMed CAS Google Scholar
• Aljada A, Garg R, Ghanim H, et al.: Nuclear factor-kappaB suppressive and inhibitor-kappaB stimulatory effects of troglitazone in obese patients with type 2 diabetes: evidence of an anti-inflammatory action? J Clin Endocrinol Metab 2001, 86:3250–3256.
  Article PubMed CAS Google Scholar
• Aljada A, Garg R, Ghanim H, et al.: Troglitazone reduces intranuclear activator protein (AP-1) in mononuclear cells (MNC) and plasma matrix metalloproteinase-9 (MMP-9) concentration. Diabetes 2001, 50(suppl 2):A532.
  Google Scholar
• Mohanty P, Aljada A, Ghanim H, et al.: Rosiglitazone improves vascular reactivity, inhibits reactive oxygen species (ROS) generation, reduces p47phox subunit expression in mononuclear cells (MNC) and reduces C reactive protein (CRP) and monocyte chemotactic protein-1 (MCP-1): evidence of a potent anti-inflammatory effect. Diabetes 2001, 50(suppl 2):A68.
  Google Scholar
• Ghanim H, Aljada A, Mohanty P, et al.: Troglitazone suppresses pro-inflammatory transcription factors, early growth response-1 (Egr-1) and activator protein-1 (AP-1) in mononuclear cells: further evidence of the anti-inflammatory effects of troglitazone. Diabetes 2002, 51(suppl 2):A97.
  Google Scholar
• Minamikawa J, Tanaka S, Yamauchi M, et al.: Potent inhibitory effect of troglitazone on carotid arterial wall thickness in type 2 diabetes. J Clin Endocrinol Metab 1998, 83:1818–1820.
  Article PubMed CAS Google Scholar
• Koshiyama H, Shimono D, Kuwamura N, et al.: Inhibitory effect of pioglitazone on carotid arterial wall thickness in type 2 diabetes. J Clin Endocrinol Metab 2001, 86:3452–3456.
  Article PubMed CAS Google Scholar
• Dandona P, Mohanty P, Hamouda W, et al.: Inhibitory effect of a two day fast on reactive oxygen species (ROS) generation by leukocytes and plasma ortho-tyrosine and meta-tyrosine concentrations. J Clin Endocrinol Metab 2001, 86:2899–2902.
  Article PubMed CAS Google Scholar