New member of the winged-helix protein family disrupted in mouse and rat nude mutations (original) (raw)
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- Published: 03 November 1994
Nature volume 372, pages 103–107 (1994)Cite this article
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Abstract
MUTATIONS at the nude locus of mice and rats disrupt normal hair growth and thymus development1,2, causing nude mice and rats to be immune-deficient. The mouse nude locus has been localized on chromosome 11 (refs 3, 4) within a region of < 1 megabase5. Here we show that one of the genes from this critical region, designated whn, encodes a new member of the winged-helix domain family of transcription factors6,7, and that it is disrupted on mouse nu and rat rnuN alleles. Mutant transcripts do not encode the character-istic DNA-binding domain, strongly suggesting that the whn gene is the nude gene. Mutations in winged-helix domain genes cause homeotic transformations in _Drosophila_8 and distort cell-fate deci-sions during vulval development in _Caenorhabditis elegans_9. The whn gene is thus the first member of this class of genes to be implicated in a specific developmental defect in vertebrates.
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References
- Lyon, M. F. & Searle, A. G. Genetic Variants and Strains of the Laboratory Mouse (Oxford Univ. Press, Oxford, UK, 1989).
Google Scholar - Hedrich, H. (ed.). Genetic Monitoring of Inbred Strains of Rats (Fischer, Stuttgart, Germany, 1990).
- Takahashi, Y. et al. J. exp. Med. 175, 873–876 (1992).
Article CAS Google Scholar - Lisitsyn, A. N. et al. Nature Genet. 6, 57–63 (1994).
Article CAS Google Scholar - Nehls, M. et al. Eur. J. Immun. 24, 1721–1723 (1994).
Article CAS Google Scholar - Weigel, D. & Jäckle, H. Cell 63, 455–456 (1990).
Article CAS Google Scholar - Lai, E., Clark, K. L., Burley, S. K. & Darnell, J. E. Jr Proc. natn. Acad. Sci. U.S.A. 90, 10421–10423 (1993).
Article ADS CAS Google Scholar - Weigel, D., Jürgens, G., Küttner, F., Seifer, E. & Jäckle, H. Cell 57, 645–658 (1989).
Article CAS Google Scholar - Miller, L. M., Gallegos, M. E., Morisseau, B. A. & Kim, S. K. Genes Dev. 7, 933–947 (1993).
Article CAS Google Scholar - Nehls, M., Pfeifer, D. & Boehm, T. Oncogene 9, 2169–2176 (1994).
CAS PubMed Google Scholar - Cordier, A. C. & Haumont, S. M. Am. J. Anat. 157, 227–263 (1980).
Article CAS Google Scholar - Köpf-Maier, P., Mbonenko, V. F. & Merker, H. J. Acta anat. 139, 178–190 (1990).
Article Google Scholar - van Vliet, E. et al. Eur. J. Immun. 15, 675–681 (1985).
Article CAS Google Scholar - Palacios, R. & Samaridis, J. Eur. J. Immun. 21, 109–113 (1991).
Article CAS Google Scholar - Li, C., Lusis, A. J., Sparkes, T., Tran, S. M. & Gaynor, R. Genomics 13, 658–664 (1992).
Article CAS Google Scholar - Mitchell, P. J. & Tijan, R. Science 245, 371–378 (1989).
Article ADS CAS Google Scholar - Cash, J. M. et al. Mammal. Genome 4, 37–42 (1993).
Article CAS Google Scholar - Kozak, M. Nucleic Acids Res. 15, 8125–8148 (1987).
Article CAS Google Scholar - Lai, E., Prezioso, V. R., Tao, W., Chen, W. S. & Darnell, J. E. Jr Genes Dev. 5, 416–427 (1991).
Article CAS Google Scholar - Boehm, T. et al. Proc. natn. Acad. Sci. U.S.A. 88, 4367–4371 (1991).
Article ADS CAS Google Scholar - Sanger, F., Nicklen, S. & Coulson, A. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).
Article ADS CAS Google Scholar
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Authors and Affiliations
- Molecular Medicine Group, Department of Medicine I, University of Freiburg, Hugstetter Strasse 55, D-79106, Freiburg, Germany
Michael Nehls, Dietmar Pfeifer, Michael Schorpp, Hans Hedrich & Thomas Boehm - Zentrale Tierversuchsanlage, Medizinische Hochschule Hannover, Konstanty-Gutschow-Strasse 8, D-30625, Hannover-Krefeld, Germany
Hans Hedrich
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Nehls, M., Pfeifer, D., Schorpp, M. et al. New member of the winged-helix protein family disrupted in mouse and rat nude mutations.Nature 372, 103–107 (1994). https://doi.org/10.1038/372103a0
- Received: 14 June 1994
- Accepted: 25 August 1994
- Issue Date: 03 November 1994
- DOI: https://doi.org/10.1038/372103a0