On-line, voluntary control of human temporal lobe neurons (original) (raw)

References

  1. Chalupa, L., Werner, J. & Barnstable, C. The Visual Neurosciences (MIT Press, 2004)
    Google Scholar
  2. Thorpe, S. Single units and sensation: still just as relevant today. Perception 38, 804–807 (2009)
    Google Scholar
  3. Blake D. A. R., ed. Binocular Rivalry (MIT Press, 2005)
  4. Reynolds, J. & Chelazzi, L. Attentional modulation of visual processing. Annu. Rev. Neurosci. 27, 611–648 (2004)
    Article CAS Google Scholar
  5. Quian Quiroga, R. et al. Explicit encoding of multimodal percepts by single neurons in the human brain. Curr. Biol. 19, 1308–1313 (2009).
    Article CAS Google Scholar
  6. Quian Quiroga, R. et al. Invariant visual representation by single neurons in the human brain. Nature 435, 1102–1107 (2005)
    Article ADS CAS Google Scholar
  7. Földiák, P. Neural coding: non-local but explicit and conceptual. Curr. Biol. 19, R904–R906 (2009)
    Article CAS Google Scholar
  8. Kreiman, G., Koch, C. & Fried, I. Imagery neurons in the human brain. Nature 408, 357–361 (2000)
    Article ADS CAS Google Scholar
  9. Gelbard-Sagiv, H. et al. Internally generated reactivation of single neurons in human hippocampus during free recall. Science 322, 96–101 (2008)
    Article ADS CAS Google Scholar
  10. Reddy, L., Kanwisher, N. & VanRullen, R. Attention and biased competition in multi-voxel object representations. Proc. Natl Acad. Sci. USA 106, 21447–21452 (2009)
    Article ADS CAS Google Scholar
  11. Desimone, R. & Duncan, J. Neural mechanisms of selective visual attention. Annu. Rev. Neurosci. 18, 193–222 (1995)
    Article CAS Google Scholar
  12. Serences, J. et al. Control of object-based attention in human cortex. Cereb. Cortex 14, 1346–1357 (2004)
    Article Google Scholar
  13. Fried, I., MacDonald, K. & Wilson, C. Single neuron activity in human hippocampus and amygdala during recognition of faces and objects. Neuron 18, 753–765 (1997)
    Article CAS Google Scholar
  14. Quian Quiroga, R. et al. Decoding visual inputs from multiple neurons in the human temporal lobe. J. Neurophysiol. 98, 1997–2007 (2007)
    Article Google Scholar
  15. Musallam, S. et al. Cognitive control signals for neural prosthetics. Science 305, 258–262 (2004)
    Article ADS CAS Google Scholar
  16. Wessberg, J. et al. Real-time prediction of hand trajectory by ensembles of cortical neurons in primates. Nature 408, 361–365 (2000)
    Article ADS CAS Google Scholar
  17. Velliste, M. et al. Cortical control of a prosthetic arm for self-feeding. Nature 453, 1098–1101 (2008)
    Article ADS CAS Google Scholar
  18. Moritz, C., Perlmutter, S. & Fetz, E. Direct control of paralysed muscles by cortical neurons. Nature 456, 639–642 (2008)
    Article ADS CAS Google Scholar
  19. Hochberg, L. et al. Neuronal ensemble control of prosthetic devices by a human with tetraplegia. Nature 442, 164–171 (2006)
    Article ADS CAS Google Scholar
  20. Kim, S. et al. Neural control of computer cursor velocity by decoding motor cortical spiking activity in humans with tetraplegia. J. Neural Eng. 5, 455–476 (2008)
    Article ADS Google Scholar
  21. Kennedy, P. et al. Direct control of a computer from the human central nervous system. IEEE Trans. Rehabil. Eng. 8, 198–202 (2000)
    Article CAS Google Scholar
  22. Guenther, F. et al. A wireless brain-machine interface for real-time speech synthesis. PLoS ONE 4, e8218 (2009)
    Article ADS CAS Google Scholar
  23. Waydo, S. et al. Sparse representation in the human medial temporal lobe. J. Neurosci. 26, 10232–10234 (2006)
    Article CAS Google Scholar

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Acknowledgements

We thank the patients for their participation in these studies. We thank K. Laird, A. Postolova, N. Parikshak and V. Isiaka for help with the recordings; E. Behnke and T. Fields for technical support; G. Mulliken and U. Rutishauser for comments on the manuscript; and M. Moon for help with data visualization. This work was supported by grants from the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Mental Health (NIMH), the G. Harold & Leila Y. Mathers Charitable Foundation, and the WCU programme through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (R31-2008-000-10008-0).

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Author notes

  1. Christof Koch and Itzhak Fried: These authors contributed equally to this work.

Authors and Affiliations

  1. Computation and Neural Systems, California Institute of Technology, Pasadena, 91125, California, USA
    Moran Cerf, Nikhil Thiruvengadam, Florian Mormann, Alexander Kraskov, Rodrigo Quian Quiroga & Christof Koch
  2. Department of Neurosurgery, University of California, Los Angeles, 90095, California, USA
    Moran Cerf & Itzhak Fried
  3. Stern School of Business, New York University, New York, New York 10012, USA,
    Moran Cerf
  4. School of Computer Science, Carnegie Mellon University, Pittsburgh, 15213, Pennsylvania, USA
    Nikhil Thiruvengadam
  5. Department of Epileptology, University of Bonn, Bonn 53105, Germany
    Florian Mormann
  6. Department of Engineering, University of Leicester, Leicester LE1 7RH, UK,
    Rodrigo Quian Quiroga
  7. Department of Brain and Cognitive Engineering, Korea University, Seoul, 136-713, Korea,
    Christof Koch
  8. Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, 90095, California, USA
    Itzhak Fried
  9. Functional Neurosurgery Unit, Tel-Aviv Medical Center, Tel-Aviv 64239, Israel,
    Itzhak Fried
  10. Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel
    Itzhak Fried

Authors

  1. Moran Cerf
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  2. Nikhil Thiruvengadam
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  3. Florian Mormann
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  4. Alexander Kraskov
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  5. Rodrigo Quian Quiroga
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  6. Christof Koch
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  7. Itzhak Fried
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Contributions

M.C., F.M., R.Q.Q., C.K. and I.F. designed the experiment; M.C. performed the experiments; I.F. performed the surgeries; M.C. and N.T. analysed the data; M.C., C.K. and I.F. wrote the manuscript. All authors discussed the data and the analysis methods and contributed to the manuscript.

Corresponding authors

Correspondence toMoran Cerf, Christof Koch or Itzhak Fried.

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Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Information

This file contains Supplementary Methods and Results, Supplementary Figures 1-9 with legends, legends for Supplementary Movie 1 and additional references. (PDF 6206 kb)

Supplementary Movie 1

An example of a feedback experiment, this movie has three parts. The first part shows the control presentation, part two shows a sequence of trials from the actual experiment and part three shows the 16 Monroe Brolin trials in the order they appeared in the experiment - see Supplementary Information file for full legend. (MP4 12778 kb)

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Cerf, M., Thiruvengadam, N., Mormann, F. et al. On-line, voluntary control of human temporal lobe neurons.Nature 467, 1104–1108 (2010). https://doi.org/10.1038/nature09510

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