Dead man walking: how thymocytes scan the medulla (original) (raw)
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- Published: August 2009
Nature Immunology volume 10, pages 809–811 (2009)Cite this article
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The thymic medulla provides a unique milieu for the induction of T cell tolerance. New work now provides a first glimpse of how thymocytes scan this microenvironment and thus maximize their chances of encountering self antigen.
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Figure 1: Linking the topology and timing of T cell development with thymocyte motility.
References
- Petrie, H.T. & Zuniga-Pflucker, J.C. Annu. Rev. Immunol. 25, 649–679 (2007).
Article CAS Google Scholar - Le Borgne, M. et al. Nat. Immunol. 10, 823–830 (2009).
Article CAS Google Scholar - Kyewski, B. & Klein, L. Annu. Rev. Immunol. 24, 571–606 (2006).
Article CAS Google Scholar - Li, J., Park, J., Foss, D. & Goldschneider, I. J. Exp. Med. 206, 607–622 (2009).
Article CAS Google Scholar - Proietto, A.I. et al. Proc. Natl. Acad. Sci. USA 105, 19869–19874 (2008).
Article CAS Google Scholar - Wirnsberger, G., Mair, F. & Klein, L. Proc. Natl. Acad. Sci. USA 106, 10278–10283 (2009).
Article CAS Google Scholar - Derbinski, J., Pinto, S., Rosch, S., Hexel, K. & Kyewski, B. Proc. Natl. Acad. Sci. USA 105, 657–662 (2008).
Article CAS Google Scholar - Venanzi, E.S., Melamed, R., Mathis, D. & Benoist, C. Proc. Natl. Acad. Sci. USA 105, 15860–15865 (2008).
Article CAS Google Scholar - Gallegos, A.M. & Bevan, M.J. J. Exp. Med. 200, 1039–1049 (2004).
Article CAS Google Scholar - Koble, C. & Kyewski, B. J. Exp. Med. published online, doi:10.1084/jem.20082449 (29 June 2009).
- Witt, C.M., Raychaudhuri, S., Schaefer, B., Chakraborty, A.K. & Robey, E.A. PLoS Biol. 3, e160 (2005).
Article Google Scholar - Miller, M.J., Hejazi, A.S., Wei, S.H., Cahalan, M.D. & Parker, I. Proc. Natl. Acad. Sci. USA 101, 998–1003 (2004).
Article CAS Google Scholar - Rodewald, H.R., Paul, S., Haller, C., Bluethmann, H. & Blum, C. Nature 414, 763–768 (2001).
Article CAS Google Scholar - Bautista, J.L. et al. Nat. Immunol. 10, 610–617 (2009).
Article CAS Google Scholar
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Authors and Affiliations
- Ludger Klein is with the Institute for Immunology, Ludwig-Maximilian-University, Munich, Germany. ludger.klein@med.lmu.de,
Ludger Klein
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Klein, L. Dead man walking: how thymocytes scan the medulla.Nat Immunol 10, 809–811 (2009). https://doi.org/10.1038/ni0809-809
- Issue Date: August 2009
- DOI: https://doi.org/10.1038/ni0809-809