Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood (original) (raw)

• Bone, R.C. Sepsis, the sepsis syndrome, multi-organ failure: a plea for comparable definitions. Ann. Intern. Med. 114, 332–333 (1991).
  Article CAS PubMed Google Scholar
• Welbourn, C.R. & Young, Y. Endotoxin, septic shock and acute lung injury: neutrophils, macrophages and inflammatory mediators. Br. J. Surg. 79, 998–1003 (1992).
  Article CAS PubMed Google Scholar
• Mavrommatis, A.C. et al. Coagulation system and platelets are fully activated in uncomplicated sepsis. Crit. Care Med. 28, 451–457 (2000).
  Article CAS PubMed Google Scholar
• Mercer, K.W., Gail, M.B. & Williams, M.E. Hematologic disorders in critically ill patients. Semin. Respir. Crit. Care Med. 27, 286–296 (2006).
  Article PubMed Google Scholar
• Andonegui, G. et al. Platelets express functional Toll-like receptor-4. Blood 106, 2417–2423 (2005).
  Article CAS PubMed Google Scholar
• Stohlawetz, P. et al. Effects of endotoxemia on thrombopoiesis in men. Thromb. Haemost. 81, 613–617 (1999).
  CAS PubMed Google Scholar
• Klinger, M.H. & Jelkmann, W. Role of blood platelets in infection and inflammation. J. Interferon Cytokine Res. 22, 913–922 (2002).
  Article CAS PubMed Google Scholar
• Aslam, R. et al. Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-α production in vivo. Blood 107, 637–641 (2006).
  Article CAS PubMed Google Scholar
• Ward, J.R. et al. Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor. Thromb. Haemost. 94, 831–838 (2005).
  PubMed Google Scholar
• Brinkmann, V. et al. Neutrophil extracellular traps kill bacteria. Science 303, 1532–1535 (2004).
  Article CAS PubMed Google Scholar
• Mullarkey, M. et al. Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist. J. Pharmacol. Exp. Ther. 304, 1093–1102 (2003).
  Article CAS PubMed Google Scholar
• Lynn, M. et al. Extended in vivo pharmacodynamic activity of E5564 in normal volunteers with experimental endotoxemia [corrected]. J. Pharmacol. Exp. Ther. 308, 175–181 (2004).
  Article CAS PubMed Google Scholar
• Singer, G., Urakami, H., Specian, R.D., Stokes, K.Y. & Granger, D.N. Platelet recruitment in the murine hepatic microvasculature during experimental sepsis: role of neutrophils. Microcirculation 13, 89–97 (2006).
  Article CAS PubMed Google Scholar
• Beiter, K. et al. An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps. Curr. Biol. 16, 401–407 (2006).
  Article CAS PubMed Google Scholar
• Buchanan, J.T. et al. DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps. Curr. Biol. 16, 396–400 (2006).
  Article CAS PubMed Google Scholar
• Fuchs, T.A. et al. Novel cell death program leads to neutrophil extracellular traps. J. Cell Biol. 176, 231–241 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Gross, K. et al. Bacterial clearance in the intact and regenerating liver. J. Pediatr. Surg. 20, 320–323 (1985).
  Article CAS PubMed Google Scholar
• Vincent, J.L., Yagushi, A. & Pradier, O. Platelet function in sepsis. Crit. Care Med. 30, S313–S317 (2002).
  Article CAS PubMed Google Scholar
• Ruf, A. & Patscheke, H. Platelet-induced neutrophil activation: platelet-expressed fibrinogen induces the oxidative burst in neutrophils by an interaction with CD11C/CD18. Br. J. Haematol. 90, 791–796 (1995).
  Article CAS PubMed Google Scholar
• Segal, A.W. How neutrophils kill microbes. Annu. Rev. Immunol. 23, 197–223 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Akgul, C., Moulding, D.A. & Edwards, S.W. Molecular control of neutrophil apoptosis. FEBS Lett. 487, 318–322 (2001).
  Article CAS PubMed Google Scholar
• Borregaard, N. & Cowland, J.B. Granules of the human neutrophilic polymorphonuclear leukocyte. Blood 89, 3503–3521 (1997).
  CAS PubMed Google Scholar
• Moraes, T.J., Zurawska, J.H. & Downey, G.P. Neutrophil granule contents in the pathogenesis of lung injury. Curr. Opin. Hematol. 13, 21–27 (2006).
  Article CAS PubMed Google Scholar
• Sheridan, B.C. et al. Neutrophils mediate pulmonary vasomotor dysfunction in endotoxin-induced acute lung injury. J. Trauma 42, 391–396 (1997).
  Article CAS PubMed Google Scholar
• Alghamdi, A.S. & Foster, D.N. Seminal DNase frees spermatozoa entangled in neutrophil extracellular traps. Biol. Reprod. 73, 1174–1181 (2005).
  Article CAS PubMed Google Scholar
• Frenette, P.S., Johnson, R.C., Hynes, R.O. & Wagner, D.D. Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectin. Proc. Natl. Acad. Sci. USA 92, 7450–7454 (1995).
  Article CAS PubMed Google Scholar
• Heit, B., Tavener, S., Raharjo, E. & Kubes, P. An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients. J. Cell Biol. 159, 91–102 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Kubes, P., Kanwar, S., Niu, X.F. & Gaboury, J.P. Nitric oxide synthesis inhibition induces leukocyte adhesion via superoxide and mast cells. FASEB J. 7, 1293–1299 (1993).
  Article CAS PubMed Google Scholar
• Lloyd, K.L. & Kubes, P. GPI-linked endothelial CD14 contributes to the detection of LPS. Am. J. Physiol. Heart Circ. Physiol. 291, H473–H481 (2006).
  Article CAS PubMed Google Scholar
• Ibbotson, G.C. et al. Functional α4-integrin: a newly identified pathway of neutrophil recruitment in critically ill septic patients. Nat. Med. 7, 465–470 (2001).
  Article CAS PubMed Google Scholar
• Reinhardt, P.H. & Kubes, P. Differential leukocyte recruitment from whole blood via endothelial adhesion molecules under shear conditions. Blood 92, 4691–4699 (1998).
  CAS PubMed Google Scholar
• Gill, V., Doig, C., Knight, D., Love, E. & Kubes, P. Targeting adhesion molecules as a potential mechanism of action for intravenous immunoglobulin. Circulation 112, 2031–2039 (2005).
  Article CAS PubMed Google Scholar
• Bonder, C.S. et al. Rules of recruitment for Th1 and Th2 lymphocytes in inflamed liver: a role for α-4 integrin and vascular adhesion protein-1. Immunity 23, 153–163 (2005).
  Article CAS PubMed Google Scholar
• Wong, J. et al. A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature. J. Clin. Invest. 99, 2782–2790 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Hickey, M.J. et al. Inducible nitric oxide synthase-deficient mice have enhanced leukocyte-endothelium interactions in endotoxemia. FASEB J. 11, 955–964 (1997).
  Article CAS PubMed Google Scholar
• Nishida, J., McCuskey, R.S., McDonnell, D. & Fox, E.S. Protective role of NO in hepatic microcirculatory dysfunction during endotoxemia. Am. J. Physiol. 267, G1135–G1141 (1994).
  CAS PubMed Google Scholar
• Li, Y., Muruve, D.A., Collins, R.G., Lee, S.S. & Kubes, P. The role of selectins and integrins in adenovirus vector-induced neutrophil recruitment to the liver. Eur. J. Immunol. 32, 3443–3452 (2002).
  Article CAS PubMed Google Scholar
• Carvalho-Tavares, J. et al. A role for platelets and endothelial selectins in tumor necrosis factor- α-induced leukocyte recruitment in the brain microvasculature. Circ. Res. 87, 1141–1148 (2000).
  Article CAS PubMed Google Scholar