Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial (original) (raw)
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17 September 2007
Nat. Med. 13, 1102-1107 (2007); published online 2 September; corrected after print 17 September 2007. In the version of this article initially published, the affiliation of the name of one person acknowledged was misspelled, and reference 4 should have been: Moghaddam, B. & Adams, B.W. Reversal of phenylcyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science 281, 1349–1352. These errors have been corrected in the HTML and PDF versions of the article.
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Acknowledgements
We thank the Lilly Russian Affiliate Team (E. Faustova, N. Jarkova, O. Orlova, O. Larionova, M. Ipatov, M. Putilovsky), the Lilly mGlu2/3 Program Team, R.C. Mohs, X. Peng, P. Cana, S. Marrero, A. Delvaux, J. Ryner, B. Moser, D. Michelson, B. Kinon, A. Stepanov, E. Roberts, I. Pavo, B. Gaydos, D. Manner, F. Wilhite, W.Z. Potter, C.M. Beasley and S.M. Paul.
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Author notes
- Sandeep T Patil & Darryle D Schoepp
Present address: Present addresses: Takeda Global Research and Development Center, Inc., One Takeda Parkway, Deerfield, Illinois 60015, USA (S.T.P.); Merck and Company, Inc., 351 Sumneytown Pike, UG/4CDS013, North Wales, Pennsylvania 19454, USA (D.D.S.).,
Authors and Affiliations
- Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, 46285, Indiana, USA
Sandeep T Patil, Lu Zhang, Bryan G Johnson, James A Monn & Darryle D Schoepp - Lilly Medical Center, Kolblgasse 8-10, Vienna, A-1030, Austria
Ferenc Martenyi - Lilly-National University of Singapore Centre for Clinical Pharmacology, Level 6 Clinical Research Centre (MD11), 10 Medical Drive, 117597, Singapore
Stephen L Lowe - Lilly-Erl Wood Manor, Windlesham, GU20 6PH, Surrey, UK
Kimberley A Jackson - St. Petersburg State University, St. Petersburg and Gatchinskiy Regional Psychiatric Hospital, Nikolskoe, 188357, Russia
Boris V Andreev - Serbsky State Scientific Center of Social and Forensic Psychiatry, 23, Kropotkinskiy per, Moscow, 123367, Russia
Alla S Avedisova - Moscow State University of Medicine and Dentistry based at Moscow Psychiatry Hospital no. 15, Moscvorechie ul. 7, Moscow, 115522, Russia
Leonid M Bardenstein - Moscow Research Institute of Psychiatry, Poteshnaya ul. 3, Moscow, 107076, Russia
Issak Y Gurovich & Sergey N Mosolov - State Institution “Mental Health Scientific Research Center of the Russian Academy of Medical Sciences”, Kashyrskoye sh. 34, Moscow, 115522, Russia
Margarita A Morozova & Anatoly B Smulevich - Bekhterev Research Psychoneurological Institute, Bekhtereva ul. 3, St. Petersburg, 192019, Russia
Nikolai G Neznanov - Moscow Regional Psychiatry Hospital #5, Abramtsevskoye sh. 1a, Khotkovo, 142601, Moscow region, Russia
Alexander M Reznik - Mechnikov State Medical Academy, Naberezhnaya reki Mojki, 126, St. Petersburg, 190121, Russia
Vladimir A Tochilov
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Correspondence toFerenc Martenyi or James A Monn.
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Competing interests
S.T.P., L.Z., F.M., S.L.L., K.A.J., J.A.M., B.G.J., & D.D.S. are/were employees of Eli Lilly and Company at the time of this clinical study. Several of them own Lilly stock.
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Patil, S., Zhang, L., Martenyi, F. et al. Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial.Nat Med 13, 1102–1107 (2007). https://doi.org/10.1038/nm1632
- Received: 05 December 2006
- Accepted: 24 July 2007
- Published: 02 September 2007
- Issue Date: September 2007
- DOI: https://doi.org/10.1038/nm1632