Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse (original) (raw)

• Mattson, B.J. et al. Cocaine-induced CREB phosphorylation in nucleus accumbens of cocaine-sensitized rats is enabled by enhanced activation of extracellular signal–related kinase, but not protein kinase A. J. Neurochem. 95, 1481–1494 (2005).
  Article CAS Google Scholar
• McClung, C.A. & Nestler, E.J. Regulation of gene expression and cocaine reward by CREB and DeltaFosB. Nat. Neurosci. 6, 1208–1215 (2003).
  Article CAS Google Scholar
• Shaw-Lutchman, T.Z., Impey, S., Storm, D. & Nestler, E.J. Regulation of CRE-mediated transcription in mouse brain by amphetamine. Synapse 48, 10–17 (2003).
  Article CAS Google Scholar
• Altar, C.A. et al. Anterograde transport of brain-derived neurotrophic factor and its role in the brain. Nature 389, 856–860 (1997).
  Article CAS Google Scholar
• Gall, C.M. Regulation of brain neurotrophin expression by physiological activity. Trends Pharmacol. Sci. 13, 401–403 (1992).
  Article CAS Google Scholar
• Guillin, O. et al. BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization. Nature 411, 86–89 (2001).
  Article CAS Google Scholar
• Seroogy, K.B. et al. Dopaminergic neurons in rat ventral midbrain express brain-derived neurotrophic factor and neurotrophin-3 mRNAs. J. Comp. Neurol. 342, 321–334 (1994).
  Article CAS Google Scholar
• Choi, K.H., Whisler, K., Graham, D.L. & Self, D.W. Antisense-induced reduction in nucleus accumbens cyclic AMP response element binding protein attenuates cocaine reinforcement. Neuroscience 137, 373–383 (2006).
  Article CAS Google Scholar
• Pandey, S.C., Roy, A., Zhang, H. & Xu, T. Partial deletion of the cAMP response element–binding protein gene promotes alcohol-drinking behaviors. J. Neurosci. 24, 5022–5030 (2004).
  Article CAS Google Scholar
• Elmer, E. et al. Dynamic changes of brain-derived neurotrophic factor protein levels in the rat forebrain after single and recurring kindling-induced seizures. Neuroscience 83, 351–362 (1998).
  Article CAS Google Scholar
• Filip, M. et al. Alterations in BDNF and trkB mRNAs following acute or sensitizing cocaine treatments and withdrawal. Brain Res. 1071, 218–225 (2006).
  Article CAS Google Scholar
• Liu, Q.R. et al. Rodent BDNF genes, novel promoters, novel splice variants and regulation by cocaine. Brain Res. 1067, 1–12 (2006).
  Article CAS Google Scholar
• Kuppers, E. & Beyer, C. Dopamine regulates brain-derived neurotrophic factor (BDNF) expression in cultured embryonic mouse striatal cells. Neuroreport 12, 1175–1179 (2001).
  Article CAS Google Scholar
• Narita, M., Aoki, K., Takagi, M., Yajima, Y. & Suzuki, T. Implication of brain-derived neurotrophic factor in the release of dopamine and dopamine-related behaviors induced by methamphetamine. Neuroscience 119, 767–775 (2003).
  Article CAS Google Scholar
• Horger, B.A. et al. Enhancement of locomotor activity and conditioned reward to cocaine by brain-derived neurotrophic factor. J. Neurosci. 19, 4110–4122 (1999).
  Article CAS Google Scholar
• Huang, E.J. & Reichardt, L.F. Trk receptors: roles in neuronal signal transduction. Annu. Rev. Biochem. 72, 609–642 (2003).
  Article CAS Google Scholar
• Kumar, A. et al. Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron 48, 303–314 (2005).
  Article CAS Google Scholar
• Grimm, J.W. et al. Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving. J. Neurosci. 23, 742–747 (2003).
  Article CAS Google Scholar
• Ahmed, S.H. & Koob, G.F. Transition from moderate to excessive drug intake: change in hedonic set point. Science 282, 298–300 (1998).
  Article CAS Google Scholar
• Ahmed, S.H., Walker, J.R. & Koob, G.F. Persistent increase in the motivation to take heroin in rats with a history of drug escalation. Neuropsychopharmacology 22, 413–421 (2000).
  Article CAS Google Scholar
• Piazza, P.V., Deroche-Gamonent, V., Rouge-Pont, F. & Le Moal, M. Vertical shifts in self-administration dose-response functions predict a drug-vulnerable phenotype predisposed to addiction. J. Neurosci. 20, 4226–4232 (2000).
  Article CAS Google Scholar
• Robledo, P. & Koob, G.F. Two discrete nucleus accumbens projection areas differentially mediate cocaine self-administration in the rat. Behav. Brain Res. 55, 159–166 (1993).
  Article CAS Google Scholar
• Jaffe, J.H., Cascella, N.G., Kumor, K.M. & Sherer, M.A. Cocaine-induced cocaine craving. Psychopharmacology (Berl.) 97, 59–64 (1989).
  Article CAS Google Scholar
• Sinha, R., Catapano, D. & O'Malley, S. Stress-induced craving and stress response in cocaine-dependent individuals. Psychopharmacology (Berl.) 142, 343–351 (1999).
  Article CAS Google Scholar
• DSM-IV-TR. Diagnostic and Statistical Manual of Mental Disorders, 4th. Ed., Text Revision (American Psychiatric Association, Washington, DC, 2000).
• Castren, E., Thoenen, H. & Lindholm, D. Brain-derived neurotrophic factor messenger RNA is expressed in the septum, hypothalamus and in adrenergic brain stem nuclei of adult rat brain and is increased by osmotic stimulation in the paraventricular nucleus. Neuroscience 64, 71–80 (1995).
  Article CAS Google Scholar
• Conner, J.M., Lauterborn, J.C., Yan, Q., Gall, C.M. & Varon, S. Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport. J. Neurosci. 17, 2295–2313 (1997).
  Article CAS Google Scholar
• Hofer, M., Pagliusi, S.R., Hohn, A., Leibrock, J. & Barde, Y.A. Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. EMBO J. 9, 2459–2464 (1990).
  Article CAS Google Scholar
• Le Foll, B., Diaz, J. & Sokoloff, P. A single cocaine exposure increases BDNF and D3 receptor expression: implications for drug-conditioning. Neuroreport 16, 175–178 (2005).
  Article CAS Google Scholar
• Hall, F.S., Drgonova, J., Goeb, M. & Uhl, G.R. Reduced behavioral effects of cocaine in heterozygous brain-derived neurotrophic factor (BDNF) knockout mice. Neuropsychopharmacology 28, 1485–1490 (2003).
  Article CAS Google Scholar
• Altar, C.A. et al. Brain-derived neurotrophic factor augments rotational behavior and nigrostriatal dopamine turnover in vivo. Proc. Natl. Acad. Sci. USA 89, 11347–11351 (1992).
  Article CAS Google Scholar
• Martin-Iverson, M.T., Todd, K.G. & Altar, C.A. Brain-derived neurotrophic factor and neurotrophin-3 activate striatal dopamine and serotonin metabolism and related behaviors: interactions with amphetamine. J. Neurosci. 14, 1262–1270 (1994).
  Article CAS Google Scholar
• Lu, L., Dempsey, J., Liu, S.Y., Bossert, J.M. & Shaham, Y. A single infusion of brain-derived neurotrophic factor into the ventral tegmental area induces long-lasting potentiation of cocaine seeking after withdrawal. J. Neurosci. 24, 1604–1611 (2004).
  Article CAS Google Scholar
• Pu, L., Liu, Q.S. & Poo, M.M. BDNF-dependent synaptic sensitization in midbrain dopamine neurons after cocaine withdrawal. Nat. Neurosci. 9, 605–607 (2006).
  Article CAS Google Scholar
• Altar, C.A., Fritsche, M. & Lindsay, R.M. Cell body infusions of brain-derived neurotrophic factor increase forebrain dopamine release and serotonin metabolism determined with in vivo microdialysis. Adv. Pharmacol. 42, 915–921 (1998).
  Article CAS Google Scholar
• Mufson, E.J. et al. Intrastriatal and intraventricular infusion of brain-derived neurotrophic factor in the cynomologous monkey: distribution, retrograde transport and colocalization with substantia nigra dopamine-containing neurons. Neuroscience 71, 179–191 (1996).
  Article CAS Google Scholar
• Mufson, E.J. et al. Intrastriatal infusions of brain-derived neurotrophic factor: retrograde transport and colocalization with dopamine containing substantia nigra neurons in rat. Exp. Neurol. 129, 15–26 (1994).
  Article CAS Google Scholar
• Colby, C.R., Whisler, K., Steffen, C., Nestler, E.J. & Self, D.W. Striatal cell type–specific overexpression of DeltaFosB enhances incentive for cocaine. J. Neurosci. 23, 2488–2493 (2003).
  Article CAS Google Scholar
• Nakao, N., Kokaia, Z., Odin, P. & Lindvall, O. Protective effects of BDNF and NT-3 but not PDGF against hypoglycemic injury to cultured striatal neurons. Exp. Neurol. 131, 1–10 (1995).
  Article CAS Google Scholar
• Bibel, M. & Barde, Y.A. Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev. 14, 2919–2937 (2000).
  Article CAS Google Scholar
• Robinson, T.E., Gorny, G., Mitton, E. & Kolb, B. Cocaine self-administration alters the morphology of dendrites and dendritic spines in the nucleus accumbens and neocortex. Synapse 39, 257–266 (2001).
  Article CAS Google Scholar
• Robinson, T.E. & Kolb, B. Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine. Eur. J. Neurosci. 11, 1598–1604 (1999).
  Article CAS Google Scholar
• Rex, C.S. et al. Brain-derived neurotrophic factor promotes long-term potentiation–related cytoskeletal changes in adult hippocampus. J. Neurosci. 27, 3017–3029 (2007).
  Article CAS Google Scholar
• Rios, M. et al. Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol. Endocrinol. 15, 1748–1757 (2001).
  Article CAS Google Scholar
• Sutton, M.A. et al. Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour. Nature 421, 70–75 (2003).
  Article CAS Google Scholar
• Le, Y., Miller, J.L. & Sauer, B. GFPcre fusion vectors with enhanced expression. Anal. Biochem. 270, 334–336 (1999).
  Article CAS Google Scholar
• Hommel, J.D., Sears, R.M., Georgescu, D., Simmons, D.L. & DiLeone, R.J. Local gene knockdown in the brain using viral-mediated RNA interference. Nat. Med. 9, 1539–1544 (2003).
  Article CAS Google Scholar