Levenstein, S. et al. Stress and exacerbation in ulcerative colitis: a prospective study of patients enrolled in remission. Am. J. Gastroenterol.95, 1213–1220 (2000). ArticleCASPubMed Google Scholar
Whitehead, W. E., Crowell, M. D., Robinson, J. C., Heller, B. R. & Schuster, M. M. Effects of stressful life events on bowel symptoms: subjects with irritable bowel syndrome compared with subjects without bowel dysfunction. Gut33, 825–830 (1992). ArticleCASPubMedPubMed Central Google Scholar
Urban, M. O. & Gebhart, G. F. Central mechanisms in pain. Med. Clin. North Am.83, 585–596 (1999). ArticleCASPubMed Google Scholar
Castagliuolo, I. et al. Neuronal involvement in the intestinal effects of Clostridium difficile toxin A and Vibrio cholerae enterotoxin in rat ileum. Gastroenterology107, 657–665 (1994). ArticleCASPubMed Google Scholar
Mazmanian, S. K. et al. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature453, 620–625 (2008). ArticleCASPubMed Google Scholar
Guarner, F. & Malagelada, J. R. Gut flora in health and disease. Lancet361, 512–519 (2003). ArticlePubMed Google Scholar
Husebye, E., Hellstrom, P. M., Sundler, F., Chen, J. & Midtvedt, T. Influence of microbial species on small intestinal myoelectric activity and transit in germ-free rats. Am. J. Physiol. Gastrointest. Liver Physiol.280, G368–G380 (2001). ArticleCASPubMed Google Scholar
Rhee, S. H. et al. Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proc. Natl Acad. Sci. USA102, 13610–13615 (2005). ArticleCASPubMedPubMed Central Google Scholar
Ait-Belgnaoui, A. et al. Lactobacillus farciminis treatment suppresses stress induced visceral hypersensitivity: a possible action through interaction with epithelial cell cytoskeleton contraction. Gut55, 1090–1094 (2006). ArticleCASPubMedPubMed Central Google Scholar
Spiller, P. Review article: probiotics and prebiotics in irritable bowel syndrome (IBS). Aliment. Pharmacol. Ther. (2008). Google Scholar
Agrawal, A. et al. Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173-010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation. Aliment. Pharmacol. Ther. (In press).
Vanderpool, C., Yan, F. & Polk, D. B. Mechanisms of probiotic action: implications for therapeutic applications in inflammatory bowel diseases. Inflamm. Bowel Dis.14, 1585–1596 (2008). ArticlePubMed Google Scholar
Schaedler, R. W. & Dubos, R. J. The fecal flora of various strains of mice. Its bearing on their susceptibility to endotoxin. J. Exp. Med.115, 1149–1160 (1962). ArticleCASPubMedPubMed Central Google Scholar
Bailey, M. T. & Coe, C. L. Maternal separation disrupts the integrity of the intestinal microflora in infant rhesus monkeys. Dev. Psychobiol.35, 146–155 (1999). ArticleCASPubMed Google Scholar
Bailey, M. T. et al. Prenatal stress alters bacterial colonization of the gut in infant monkeys. J. Pediatr. Gastroenterol. Nutr.38, 414–421 (2004). ArticlePubMed Google Scholar
Holstege, G. et al. The Emotional Motor System (Elsevier, Amsterdam, 1996). Book Google Scholar
Macfarlane, S. & Dillon, J. F. Microbial biofilms in the human gastrointestinal tract. J. Appl. Microbiol.102, 1187–1196 (2007). ArticleCASPubMed Google Scholar
Van Felius, I. D. et al. Interdigestive small bowel motility and duodenal bacterial overgrowth in experimental acute pancreatitis. Neurogastroenterol. Motil.15, 267–276 (2003). ArticleCASPubMed Google Scholar
Chey, W. Y. et al. Colonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrhea. Am. J. Gastroenterol.96, 1499–1506 (2001). ArticleCASPubMed Google Scholar
Kiliaan, A. J. et al. Stress stimulates transepithelial macromolecular uptake in rat jejunum. Am. J. Physiol.275, G1037–G1044 (1998). CASPubMed Google Scholar
Groot, J. et al. Stress-induced decrease of the intestinal barrier function. The role of muscarinic receptor activation. Ann. NY Acad. Sci.915, 237–246 (2000). ArticleCASPubMed Google Scholar
Yates, D. A., Santos, J., Soderholm, J. D. & Perdue, M. H. Adaptation of stress-induced mucosal pathophysiology in rat colon involves opioid pathways. Am. J. Physiol. Gastrointest. Liver Physiol.281, G124–G128 (2001). ArticleCASPubMed Google Scholar
Soderholm, J. D. et al. Neonatal maternal separation predisposes adult rats to colonic barrier dysfunction in response to mild stress. Am. J. Physiol. Gastrointest. Liver Physiol.283, G1257–G1263 (2002). ArticleCASPubMed Google Scholar
Jacob, C. et al. Mast cell tryptase controls paracellular permeability of the intestine. Role of protease-activated receptor 2 and beta-arrestins. J. Biol. Chem.280, 31936–31948 (2005). ArticleCASPubMed Google Scholar
Demaude, J. et al. Phenotypic changes in colonocytes following acute stress or activation of mast cells in mice: implications for delayed epithelial barrier dysfunction. Gut55, 655–661 (2006). ArticleCASPubMedPubMed Central Google Scholar
Salzman, N. H., Underwood, M. A. & Bevins, C. L. Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa. Semin. Immunol.19, 70–83 (2007). ArticleCASPubMed Google Scholar
Alonso, C. et al. Maladaptive intestinal epithelial responses to life stress may predispose healthy women to gut mucosal inflammation. Gastroenterology135, 163–172 (2008). ArticlePubMed Google Scholar
Stephens, R. L. & Tache, Y. Intracisternal injection of a TRH analogue stimulates gastric luminal serotonin release in rats. Am. J. Physiol.256, G377–G383 (1989). CASPubMed Google Scholar
Yang, H. et al. TRH analogue microinjected into specific medullary nuclei stimulates gastric serotonin secretion in rats. Am. J. Physiol.262, G216–G222 (1992). CAS Google Scholar
Santos, J. et al. Release of mast cell mediators into the jejunum by cold pain stress in humans. Gastroenterology114, 640–648 (1998). ArticleCASPubMed Google Scholar
Hughes, D. T. & Sperandio, V. Inter-kingdom signalling: communication between bacteria and their hosts. Nat. Rev. Microbiol.6, 111–120 (2008). ArticleCASPubMedPubMed Central Google Scholar
Alverdy, J. et al. Gut-derived sepsis occurs when the right pathogen with the right virulence genes meets the right host: evidence for in vivo virulence expression in Pseudomonas aeruginosa. Ann. Surg.232, 480–489 (2000). ArticleCASPubMedPubMed Central Google Scholar
Cogan, T. A. et al. Norepinephrine increases the pathogenic potential of Campylobacter jejuni. Gut56, 1060–1065 (2007). ArticleCASPubMed Google Scholar
Dunlop, S. P., Jenkins, D. & Spiller, R. C. Distinctive clinical, psychological, and histological features of postinfective irritable bowel syndrome. Am. J. Gastroenterol.98, 1578–1583 (2003). ArticlePubMed Google Scholar
Barbara, G. et al. Interactions between commensal bacteria and gut sensorimotor function in health and disease. Am. J. Gastroenterol.100, 2560–2568 (2005). ArticleCASPubMed Google Scholar
Dass, N. B. et al. The relationship between the effects of short-chain fatty acids on intestinal motility in vitro and GPR43 receptor activation. Neurogastroenterol. Motil.19, 66–74 (2007). ArticleCASPubMed Google Scholar
Malbert, C. H. The ileocolonic sphincter. Neurogastroenterol. Motil.17 (Suppl. 1), 41–49 (2005). ArticlePubMed Google Scholar
Nealson, K. H., Platt, T. & Hastings, J. W. Cellular control of the synthesis and activity of the bacterial luminescent system. J. Bacteriol.104, 313–322 (1970). ArticleCASPubMedPubMed Central Google Scholar
Mayer, E. A. & Baldi, J. P. Can regulatory peptides be regarded as words of a biological language? Am. J. Physiol.261, G171–G184 (1991). CASPubMed Google Scholar
Roth, J. et al. Molecules of intercellular communication in vertebrates, invertebrates and microbes: do they share common origins? Prog. Brain Res.68, 71–79 (1986). ArticleCASPubMed Google Scholar
Reading, N. C. et al. A novel two-component signaling system that activates transcription of an enterohemorrhagic Escherichia coli effector involved in remodeling of host actin. J. Bacteriol.189, 2468–2476 (2007). ArticleCASPubMedPubMed Central Google Scholar
Sperandio, V., Torres, A. G., Jarvis, B., Nataro, J. P. & Kaper, J. B. Bacteria–host communication: the language of hormones. Proc. Natl Acad. Sci. USA100, 8951–8956 (2003). ArticleCASPubMedPubMed Central Google Scholar
Irie, Y. & Parsek, M. R. Quorum sensing and microbial biofilms. Curr. Top. Microbiol. Immunol.322, 67–84 (2008). CASPubMed Google Scholar
Callaway, T. R. et al. Social stress increases fecal shedding of Salmonella typhimurium by early weaned piglets. Curr. Issues Intest. Microbiol.7, 65–71 (2006). CASPubMed Google Scholar
Rhee, S. H., Keates, A. C., Moyer, M. P. & Pothoulakis, C. MEK is a key modulator for TLR5-induced interleukin-8 and MIP3alpha gene expression in non-transformed human colonic epithelial cells. J. Biol. Chem.279, 25179–25188 (2004). ArticleCASPubMed Google Scholar
Rhee, S. H., Kim, H., Moyer, M. P. & Pothoulakis, C. Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/Toll-like receptor 5 engagement in colonic epithelial cells. J. Biol. Chem.281, 18560–18568 (2006). ArticleCASPubMed Google Scholar
Charrier, L. et al. hPepT1 mediates bacterial tripeptide fMLP uptake in human monocytes. Lab. Invest.86, 490–503 (2006). ArticleCASPubMed Google Scholar
Valet, P. et al. Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa. J. Clin. Invest.91, 2049–2055 (1993). ArticleCASPubMedPubMed Central Google Scholar
Walsh, J. H. & Mayer, E. A. Gastrointestinal peptide hormones and signal transduction. In Gastrointestinal Disease: Pathophysiology, Diagnosis, Management 5th edn (Eds Sleizenger, M. & Fordtran, J.) 18–44 (WB Saunders, Philadelphia, 1993). Google Scholar
Braun, T., Voland, P., Kunz, L., Prinz, C. & Gratzl, M. Enterochromaffin cells of the human gut: sensors for spices and odorants. Gastroenterology132, 1890–1901 (2007). ArticleCASPubMed Google Scholar
Gershon, M. D. & Tack, J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology132, 397–414 (2007). ArticleCASPubMed Google Scholar
Gershon, M. D. Nerves, reflexes, and the enteric nervous system: athogenesis of the irritable bowel syndrome. J. Clin. Gastroenterol.39, S184–S193 (2005). ArticlePubMed Google Scholar
Grider, J. R., Kuemmerle, J. F. & Jin, J. G. 5-HT released by mucosal stimuli initiates peristalsis by activating 5-HT4/5-HT1p receptors on sensory CGRP neurons. Am. J. Physiol.270, G778–G782 (1996). ArticleCASPubMed Google Scholar
Peregrin, A. T., Ahlman, H., Jodal, M. & Lundgren, O. Involvement of serotonin and calcium channels in the intestinal fluid secretion evoked by bile salt and cholera toxin. Br. J. Pharmacol.127, 887–894 (1999). ArticleCASPubMedPubMed Central Google Scholar
Raybould, H. E. Visceral perception: sensory transduction in visceral afferents and nutrients. Gut51 (Suppl. 1), i11–i14 (2002). ArticlePubMedPubMed Central Google Scholar
Hansen, M. B. & Witte, A. B. The role of serotonin in intestinal luminal sensing and secretion. Acta Physiol. (Oxf.)193, 311–323 (2008). ArticleCAS Google Scholar
Bogunovic, M. et al. Enteroendocrine cells express functional Toll-like receptors. Am. J. Physiol. Gastrointest. Liver Physiol.292, G1770–G1783 (2007). ArticleCASPubMed Google Scholar
Lencer, W. I. Microbes and microbial toxins: paradigms for microbial-mucosal toxins. V. Cholera: invasion of the intestinal epithelial barrier by a stably folded protein toxin. Am. J. Physiol. Gastrointest. Liver Physiol.280, G781–G786 (2001). ArticleCASPubMed Google Scholar
Costedio, M. M. et al. Serotonin and its role in colonic function and in gastrointestinal disorders. Dis. Colon Rectum50, 376–388 (2007). ArticlePubMed Google Scholar
Spiller, R. C. Role of infection in irritable bowel syndrome. J. Gastroenterol.42 (Suppl. 17), 41–47 (2007). ArticlePubMed Google Scholar
Grondahl, M. L. et al. Effects of nitric oxide in 5-hydroxytryptamine-, cholera toxin-, enterotoxigenic Escherichia coli and _Salmonella typhimurium_-induced secretion in the porcine small intestine. Comp. Biochem. Physiol. A Mol. Integr. Physiol.141, 476–484 (2005). ArticlePubMedCAS Google Scholar
Xue, J., Askwith, C., Javed, N. H. & Cooke, H. J. Autonomic nervous system and secretion across the intestinal mucosal surface. Auton. Neurosci.133, 55–63 (2007). ArticleCASPubMedPubMed Central Google Scholar
Wheatcroft, J. et al. Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction. Neurogastroenterol. Motil.17, 863–870 (2005). ArticleCASPubMed Google Scholar
Raybould, H. E., Cooke, H. J. & Christofi, F. L. Sensory mechanisms: transmitters, modulators and reflexes. Neurogastroenterol. Motil.16 (Suppl. 1), 60–63 (2004). ArticlePubMed Google Scholar
Schonhoff, S. E., Giel-Moloney, M. & Leiter, A. B. Minireview: development and differentiation of gut endocrine cells. Endocrinology145, 2639–2644 (2004). ArticleCASPubMed Google Scholar
O'Hara, J. R., Ho, W., Linden, D. R., Mawe, G. M. & Sharkey, K. A. Enteroendocrine cells and 5-HT availability are altered in mucosa of guinea pigs with TNBS ileitis. Am. J. Physiol. Gastrointest. Liver Physiol.287, G998–G1007 (2004). ArticleCASPubMed Google Scholar
Li, Y. Sensory signal transduction in the vagal primary afferent neurons. Curr. Med. Chem.14, 2554–2563 (2007). ArticleCASPubMed Google Scholar
Watkins, L. R. & Maier, S. F. Immune regulation of central nervous system functions: from sickness responses to pathological pain. J. Intern. Med.257, 139–155 (2005). ArticleCASPubMed Google Scholar
Watkins, L. R. & Maier, S. F. The pain of being sick: implications of immune-to-brain communication for understanding pain. Annu. Rev. Psychol.51, 29–57 (2000). ArticleCASPubMed Google Scholar
Lyte, M., Li, W., Opitz, N., Gaykema, R. P. & Goehler, L. E. Induction of anxiety-like behavior in mice during the initial stages of infection with the agent of murine colonic hyperplasia Citrobacter rodentium. Physiol. Behav.89, 350–357 (2006). ArticleCASPubMed Google Scholar
Jänig, W., Khasar, S. G., Levine, J. D. & Miao, F. J. P. The role of visceral afferents in the control of nociception. In The Biological Basis for Mind Body Interactions 1st edn ( Eds Mayer, E. A. & Saper, C. B. ) 273–287 (Elsevier Science, Amsterdam, 2000). Chapter Google Scholar
Amaral, F. A. et al. Commensal microbiota is fundamental for the development of inflammatory pain. Proc. Natl Acad. Sci. USA105, 2193–2197 (2008). ArticleCASPubMedPubMed Central Google Scholar
Sudo, N. et al. Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice. J. Physiol.558, 263–275 (2004). ArticleCASPubMedPubMed Central Google Scholar
Rousseaux, C. et al. Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors. Nat. Med.13, 35–37 (2007). ArticleCASPubMed Google Scholar
Turnbaugh, P. J. et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature444, 1027–1031 (2006). ArticlePubMed Google Scholar
Kassinen, A. et al. The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects. Gastroenterology133, 24–33 (2007). ArticleCASPubMed Google Scholar
Moayyedi, P. et al. The efficacy of probiotics in the therapy of irritable bowel syndrome: a systematic review. Gut [doi:10.1136/gut.2008.167270] (2008). ArticlePubMed Google Scholar
Bailey, M. T. et al. In vivo adaptation of attenuated Salmonella typhimurium results in increased growth upon exposure to norepinephrine. Physiol. Behav.67, 359–364 (1999). ArticleCASPubMed Google Scholar
O'Mahony, L. et al. Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. Gastroenterology128, 541–551 (2005). ArticlePubMed Google Scholar
Elenkov, I. J. & Chrousos, G. P. Stress system—organization, physiology and immunoregulation. Neuroimmunomodulation13, 257–267 (2006). ArticleCASPubMed Google Scholar
Elenkov, I. J. et al. The sympathetic nerve—an interface between two supersystems: the brain and the immune system. Pharmacol. Rev.52, 595–638 (2000). CASPubMed Google Scholar