Probing circulating tumor cells in microfluidics (original) (raw)
* Corresponding authors
a Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA
E-mail: junhuang@psu.edu
b Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
c Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA
Abstract
Circulating tumor cells (CTCs) are important targets for study as we strive to better understand, diagnose, and treat cancers. However, CTCs are found in blood at extremely low concentrations; this makes isolation, enrichment, and characterization of CTCs technically challenging. Recently, the development of CTC separation devices has grown rapidly in both academia and industry. Part of this development effort centered on microfluidic platforms, exploiting the advantages of microfluidics to improve CTC separation performance and device integration. In this Focus article, we highlight some of the recent work in microfluidic CTC separation and detection systems and discuss our appraisal of what the field should do next.
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Article information
DOI
https://doi.org/10.1039/C2LC90148J
Article type
Focus
First published
10 Jan 2013
Download Citation
Lab Chip, 2013,13, 602-609
Permissions
Probing circulating tumor cells in microfluidics
P. Li, Z. S. Stratton, M. Dao, J. Ritz and T. J. Huang,Lab Chip, 2013, 13, 602DOI: 10.1039/C2LC90148J
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