Phenotype and Genotype of Pancreatic Cancer Cell Lines : Pancreas (original) (raw)

Review

Deer, Emily L. MD; González-Hernández, Jessica BS; Coursen, Jill D. MS; Shea, Jill E. PhD; Ngatia, Josephat MD; Scaife, Courtney L. MD; Firpo, Matthew A. PhD; Mulvihill, Sean J. MD

From the Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT.

Received for publication May 28, 2009; accepted September 11, 2009.

Reprints: Matthew A. Firpo, PhD, Department of Surgery, University of Utah School of Medicine, 30 N 1900 E, Salt Lake City, UT 84132 (e-mail: [email protected]).

Ms González-Hernández is now with the University of Puerto Rico at Medical Sciences Campus, San Juan, PR.

Dr Ngatia is now with the Department of Anesthesiology, University of Florida, Gainesville, FL.

This work was supported in part by a Ruth L. Kirschstein National Research Service Award from the National Institutes of Health (T35HL07744) to E.L.D.

Buy
Erratum

Abstract

The dismal prognosis of pancreatic adenocarcinoma is due in part to a lack of molecular information regarding disease development. Established cell lines remain a useful tool for investigating these molecular events. Here we present a review of available information on commonly used pancreatic adenocarcinoma cell lines as a resource to help investigators select the cell lines most appropriate for their particular research needs. Information on clinical history; in vitro and in vivo growth characteristics; phenotypic characteristics, such as adhesion, invasion, migration, and tumorigenesis; and genotypic status of commonly altered genes (KRAS, p53, p16, and SMAD4) was evaluated. Identification of both consensus and discrepant information in the literature suggests careful evaluation before selection of cell lines and attention be given to cell line authentication.

Erratum

In the article “Phenotype and Genotype of Pancreatic Cancer Cell Lines” published in the May 2010 issue of Pancreas, an error appears in Table 1. The correct sex of the PANC-1 cell line donor is Male as indicated on page 426 of the text. The corrected table appears below:

TABLE 1

Pancreas. 47(6):e37, July 2018.