Dissociation between Rat Hippocampal CA1 and Dentate Gyrus Cells in Their Response to Corticosterone: Effects on Calcium Channel Protein and Current (original) (raw)
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1Swammerdam Institute for Life Sciences (N.G.G., D.M.M.C., H.K., M.J.), University of Amsterdam, 1098 XH Amsterdam, The Netherlands
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1Swammerdam Institute for Life Sciences (N.G.G., D.M.M.C., H.K., M.J.), University of Amsterdam, 1098 XH Amsterdam, The Netherlands
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1Swammerdam Institute for Life Sciences (N.G.G., D.M.M.C., H.K., M.J.), University of Amsterdam, 1098 XH Amsterdam, The Netherlands
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2Division of Medical Pharmacology (S.v.d.L., O.C.M.), Leiden/Amsterdam Center for Drug Research and Leiden University Medical Center, 2300 RC Leiden, The Netherlands
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3Department of Pharmacology (M.Z., J.W.H.), University of Iowa, Iowa City, Iowa 52242
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2Division of Medical Pharmacology (S.v.d.L., O.C.M.), Leiden/Amsterdam Center for Drug Research and Leiden University Medical Center, 2300 RC Leiden, The Netherlands
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3Department of Pharmacology (M.Z., J.W.H.), University of Iowa, Iowa City, Iowa 52242
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1Swammerdam Institute for Life Sciences (N.G.G., D.M.M.C., H.K., M.J.), University of Amsterdam, 1098 XH Amsterdam, The Netherlands
4Department of Neuroscience and Pharmacology (M.J.), University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
*Address all correspondence and requests for reprints to: Marian Joëls, Swammerdam Institute for Life Sciences, Center for NeuroScience, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands.
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Published:
01 October 2009
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Neeltje G. van Gemert, Diana M. M. Carvalho, Henk Karst, Siem van der Laan, Mingxu Zhang, Onno C. Meijer, Johannes W. Hell, Marian Joëls, Dissociation between Rat Hippocampal CA1 and Dentate Gyrus Cells in Their Response to Corticosterone: Effects on Calcium Channel Protein and Current, Endocrinology, Volume 150, Issue 10, 1 October 2009, Pages 4615–4624, https://doi.org/10.1210/en.2009-0525
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Abstract
Stress and corticosterone affect, via glucocorticoid receptors, cellular physiology in the rodent brain. A well-documented example concerns corticosteroid effects on high-voltage activated (L type) calcium currents in the hippocampal CA1 area. We tested whether corticosterone also affects calcium currents in another hippocampal area that highly expresses glucocorticoid receptors, i.e. the dentate gyrus (DG). Remarkably, corticosterone (100 nm, given for 20 min, 1–4.5 hr before recording) did not change high-voltage activated calcium currents in the DG, whereas currents in the CA1 area of the same rats were increased. Follow-up studies revealed that no apparent dissociation between the two areas was observed with respect to transcriptional regulation of calcium channel subunits; thus, in both areas corticosterone increased mRNA levels of the calcium channel-β4 but not the (α) Cav1.2 subunit. At the protein level, however, β4 and Cav1.2 levels were significantly up-regulated by corticosterone in the CA1 but not the DG area. These data suggest that stress-induced elevations in the level of corticosterone result in a regionally differentiated physiological response that is not simply determined by the glucocorticoid receptor distribution and that the observed regional differentiation may be caused by a gene involved in the translational machinery or in mechanisms regulating mRNA or protein stability.
Copyright © 2009 by The Endocrine Society
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