Dissociation between Rat Hippocampal CA1 and Dentate Gyrus Cells in Their Response to Corticosterone: Effects on Calcium Channel Protein and Current (original) (raw)

Journal Article

,

1Swammerdam Institute for Life Sciences (N.G.G., D.M.M.C., H.K., M.J.), University of Amsterdam, 1098 XH Amsterdam, The Netherlands

Search for other works by this author on:

,

1Swammerdam Institute for Life Sciences (N.G.G., D.M.M.C., H.K., M.J.), University of Amsterdam, 1098 XH Amsterdam, The Netherlands

Search for other works by this author on:

,

1Swammerdam Institute for Life Sciences (N.G.G., D.M.M.C., H.K., M.J.), University of Amsterdam, 1098 XH Amsterdam, The Netherlands

Search for other works by this author on:

,

2Division of Medical Pharmacology (S.v.d.L., O.C.M.), Leiden/Amsterdam Center for Drug Research and Leiden University Medical Center, 2300 RC Leiden, The Netherlands

Search for other works by this author on:

,

3Department of Pharmacology (M.Z., J.W.H.), University of Iowa, Iowa City, Iowa 52242

Search for other works by this author on:

,

2Division of Medical Pharmacology (S.v.d.L., O.C.M.), Leiden/Amsterdam Center for Drug Research and Leiden University Medical Center, 2300 RC Leiden, The Netherlands

Search for other works by this author on:

,

3Department of Pharmacology (M.Z., J.W.H.), University of Iowa, Iowa City, Iowa 52242

Search for other works by this author on:

1Swammerdam Institute for Life Sciences (N.G.G., D.M.M.C., H.K., M.J.), University of Amsterdam, 1098 XH Amsterdam, The Netherlands

4Department of Neuroscience and Pharmacology (M.J.), University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands

*Address all correspondence and requests for reprints to: Marian Joëls, Swammerdam Institute for Life Sciences, Center for NeuroScience, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands.

Search for other works by this author on:

Published:

01 October 2009

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Neeltje G. van Gemert, Diana M. M. Carvalho, Henk Karst, Siem van der Laan, Mingxu Zhang, Onno C. Meijer, Johannes W. Hell, Marian Joëls, Dissociation between Rat Hippocampal CA1 and Dentate Gyrus Cells in Their Response to Corticosterone: Effects on Calcium Channel Protein and Current, Endocrinology, Volume 150, Issue 10, 1 October 2009, Pages 4615–4624, https://doi.org/10.1210/en.2009-0525
Close

Navbar Search Filter Mobile Enter search term Search

Abstract

Stress and corticosterone affect, via glucocorticoid receptors, cellular physiology in the rodent brain. A well-documented example concerns corticosteroid effects on high-voltage activated (L type) calcium currents in the hippocampal CA1 area. We tested whether corticosterone also affects calcium currents in another hippocampal area that highly expresses glucocorticoid receptors, i.e. the dentate gyrus (DG). Remarkably, corticosterone (100 nm, given for 20 min, 1–4.5 hr before recording) did not change high-voltage activated calcium currents in the DG, whereas currents in the CA1 area of the same rats were increased. Follow-up studies revealed that no apparent dissociation between the two areas was observed with respect to transcriptional regulation of calcium channel subunits; thus, in both areas corticosterone increased mRNA levels of the calcium channel-β4 but not the (α) Cav1.2 subunit. At the protein level, however, β4 and Cav1.2 levels were significantly up-regulated by corticosterone in the CA1 but not the DG area. These data suggest that stress-induced elevations in the level of corticosterone result in a regionally differentiated physiological response that is not simply determined by the glucocorticoid receptor distribution and that the observed regional differentiation may be caused by a gene involved in the translational machinery or in mechanisms regulating mRNA or protein stability.

Copyright © 2009 by The Endocrine Society

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Dissociation between Rat Hippocampal CA1 and Dentate Gyrus Cells in Their Response to Corticosterone: Effects on Calcium Channel Protein and Current - 24 Hours access

EUR €38.00

GBP £33.00

USD $41.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 871

575 Pageviews

296 PDF Downloads

Since 1/1/2017

Citations

29 Web of Science

×

Email alerts

More on this topic

Related articles in PubMed

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic