Risk factors, characteristics and outcomes of necrotizing enterocolitis in late preterm and term infants (original) (raw)

Article type: Research Article

Affiliations: Department of Pediatrics, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia | Department of Surgery, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia

Note: [] Corresponding author: Dr. Stanley Crankson, Department of Surgery (1446), King Abdulaziz Medical City, P. O. Box 22490 Riyadh, 11426, Kingdom of Saudi Arabia. Tel.: +966 11 8011111; Fax: +966 11 2520051; E-mail: [email protected]

Abstract: OBJECTIVE: To identify the risk factors, characteristics and outcomes of necrotizing enterocolitis (NEC) at our institution. STUDY DESIGN: A retrospective case-control analysis of the charts of all late preterm and term infants, who had NEC of Bell's stage ≥ II from 1995 to 2009, along with infants of the same gestational age. Thirty-two late preterm infants had NEC meeting criteria and 128 late preterm and term infants were chosen as matched controls. RESULTS: The 32 NEC infants were more likely to have the following characteristics: a culture-proven sepsis (p = 0.0001), be small for their gestational age (p = 0.003), have a congenital heart disease (p = 0.007), and suffer from hypoxic- ischemic encephalopathy (p = 0.04). The presence of hypotension, metabolic acidosis, thrombocytopenia, and pneumoperitoneum was associated with a poor prognosis. Twelve of the 13 (92%) NEC infants who died had a surgical intervention. CONCLUSION: In this study, late preterm and term infants who developed NEC had other underlying clinical diagnoses and had culture-proven sepsis. Mortality rate was high in infants who required surgical intervention, indicating that they were gravely ill from the onset. Thrombocytopenia, hypotension and metabolic acidosis in late preterm and term infant with NEC were associated with poor prognosis.

Keywords: NEC, perinatal asphyxia, sepsis, CHD, SGA thrombocytopenia, metabolic acidosis

DOI: 10.3233/NPM-1365912

Journal: Journal of Neonatal-Perinatal Medicine, vol. 6, no. 2, pp. 125-130, 2013

Received 07 October 2012

Revision received 14 January 2013

Accepted 28 January 2013

Published: 2013