CD1a-, b-, and c-Restricted TCRs Recognize Both Self and Foreign Antigens1 (original) (raw)

Journal Article

Michael S Vincent ,

Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham & Women’s Hospital and Harvard Medical School

,

Boston, MA 02115

Address correspondence and reprint requests to Dr. Michael S. Vincent at the current address: Amgen, One Amgen Center Drive, 38-3-A, Thousand Oaks, CA 91320; E-mail address: [email protected]

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Xiaowei Xiong ,

Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham & Women’s Hospital and Harvard Medical School

,

Boston, MA 02115

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Ethan P Grant ,

Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham & Women’s Hospital and Harvard Medical School

,

Boston, MA 02115

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Wei Peng ,

Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham & Women’s Hospital and Harvard Medical School

,

Boston, MA 02115

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Michael B Brenner

Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham & Women’s Hospital and Harvard Medical School

,

Boston, MA 02115

Address correspondence and reprint requests to Dr. Michael B. Brenner, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham & Women’s Hospital and Harvard Medical School, One Jimmy Fund Way, Room 552, Boston, MA 02115; E-mail address: [email protected]

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Published:

15 November 2005

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Michael S Vincent, Xiaowei Xiong, Ethan P Grant, Wei Peng, Michael B Brenner, CD1a-, b-, and c-Restricted TCRs Recognize Both Self and Foreign Antigens, The Journal of Immunology, Volume 175, Issue 10, November 2005, Pages 6344–6351, https://doi.org/10.4049/jimmunol.175.10.6344
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Abstract

Individual CD1-restricted T cells can recognize either endogenous or foreign lipid Ags, but the extent to which the same CD1-restricted TCR can react to both self and microbial lipids is unknown. In this study, we have identified CD1a-, CD1b-, and CD1c-restricted T cells from normal human donors that induce cytolysis and secrete copious IFN-γ in response to self-CD1 expressed on monocyte-derived dendritic cells. Remarkably, microbial Ags presented by CD1 are even more potent agonists for these same T cells. The αβ T cell receptors from such clones are diverse and confer specificity for both self-CD1 and foreign lipid Ags. The dual reactivity of these CD1-restricted cells suggests that the capacity for rapid responses to inflammatory stimuli without memory coexists with the capacity for strong Ag-specific responses and the generation of memory in vivo.

Copyright © 2005 by The American Association of Immunologists

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