Memory Reactivation during Rapid Eye Movement Sleep Promotes Its Generalization and Integration in Cortical Stores (original) (raw)

Journal Article

Virginie Sterpenich, PhD ,

1Cyclotron Research Centre

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Christina Schmidt, PhD ,

1Cyclotron Research Centre

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Geneviève Albouy, PhD ,

1Cyclotron Research Centre

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Luca Matarazzo, PhD ,

1Cyclotron Research Centre

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Audrey Vanhaudenhuyse, PhD ,

Audrey Vanhaudenhuyse, PhD

1Cyclotron Research Centre

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Pierre Boveroux, MD, PhD ,

1Cyclotron Research Centre

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Christian Degueldre ,

1Cyclotron Research Centre

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Yves Leclercq, PhD ,

1Cyclotron Research Centre

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Evelyne Balteau, PhD ,

1Cyclotron Research Centre

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Fabienne Collette, PhD ,

1Cyclotron Research Centre

2Department of Cognitive Sciences, University of Liège, Liège, Belgium

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Revision received:

01 January 2014

Accepted:

01 January 2014

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Virginie Sterpenich, Christina Schmidt, Geneviève Albouy, Luca Matarazzo, Audrey Vanhaudenhuyse, Pierre Boveroux, Christian Degueldre, Yves Leclercq, Evelyne Balteau, Fabienne Collette, André Luxen, Christophe Phillips, Pierre Maquet, Memory Reactivation during Rapid Eye Movement Sleep Promotes Its Generalization and Integration in Cortical Stores, Sleep, Volume 37, Issue 6, 1 June 2014, Pages 1061–1075, https://doi.org/10.5665/sleep.3762
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Abstract

Study Objectives:

Memory reactivation appears to be a fundamental process in memory consolidation. In this study we tested the influence of memory reactivation during rapid eye movement (REM) sleep on memory performance and brain responses at retrieval in healthy human participants.

Participants:

Fifty-six healthy subjects (28 women and 28 men, age [mean ± standard deviation]: 21.6 ± 2.2 y) participated in this functional magnetic resonance imaging (fMRI) study.

Methods and Results:

Auditory cues were associated with pictures of faces during their encoding. These memory cues delivered during REM sleep enhanced subsequent accurate recollections but also false recognitions. These results suggest that reactivated memories interacted with semantically related representations, and induced new creative associations, which subsequently reduced the distinction between new and previously encoded exemplars. Cues had no effect if presented during stage 2 sleep, or if they were not associated with faces during encoding. Functional magnetic resonance imaging revealed that following exposure to conditioned cues during REM sleep, responses to faces during retrieval were enhanced both in a visual area and in a cortical region of multisensory (auditory-visual) convergence.

Conclusions:

These results show that reactivating memories during REM sleep enhances cortical responses during retrieval, suggesting the integration of recent memories within cortical circuits, favoring the generalization and schematization of the information.

© 2014 Associated Professional Sleep Societies, LLC.

Topic:

• conditioning (psychology)
• cues
• rem sleep
• memory
• sleep
• functional magnetic resonance imaging

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