ALG14 (original) (raw)

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Protein-coding gene in the species Homo sapiens

ALG14
Identifiers
Aliases ALG14, CMS15, UDP-N-acetylglucosaminyltransferase subunit, ALG14 UDP-N-acetylglucosaminyltransferase subunit, IDDEBF, MEPCA
External IDs OMIM: 612866; MGI: 1914039; HomoloGene: 49751; GeneCards: ALG14; OMA:ALG14 - orthologs
Gene location (Human)Chromosome 1 (human)Chr.Chromosome 1 (human)[1]Chromosome 1 (human)Genomic location for ALG14Genomic location for ALG14Band1p21.3Start94,974,405 bp[1]End95,072,951 bp[1]
Gene location (Mouse)Chromosome 3 (mouse)Chr.Chromosome 3 (mouse)[2]Chromosome 3 (mouse)Genomic location for ALG14Genomic location for ALG14Band3|3 G1Start121,085,422 bp[2]End121,156,743 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed incorpus epididymisjejunal mucosamucosa of colonmucosa of sigmoid colonright adrenal glandoral cavityleft adrenal glandcaput epididymisAchilles tendonpalpebral conjunctivaTop expressed insciatic nerveretinal pigment epitheliumvestibular membrane of cochlear ductcalvariaotic placodelumbar spinal ganglionmorulagenital tuberclecarotid bodyright kidneyMore reference expression dataBioGPSn/a
Gene ontologyMolecular function N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity Cellular component integral component of membrane nuclear membrane endoplasmic reticulum membrane endoplasmic reticulum membrane nucleus UDP-N-acetylglucosamine transferase complex Biological process dolichol-linked oligosaccharide biosynthetic process Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez19985766789EnsemblENSG00000172339ENSMUSG00000039887UniProtQ96F25Q9D081RefSeq (mRNA)NM_001305242NM_144988NM_024178RefSeq (protein)NP_001292171NP_659425NP_077140Location (UCSC)Chr 1: 94.97 – 95.07 MbChr 3: 121.09 – 121.16 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

UDP-N-acetylglucosamine transferase subunit ALG14 homolog is a protein that in humans is encoded by the ALG14 gene.[5][6]

Asparagine (N)-glycosylation is an essential modification that regulates protein folding and stability. ALG13 and ALG14 (this protein) constitute the UDP-GlcNAc transferase, which catalyzes a key step in endoplasmic reticulum N-linked glycosylation.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172339 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039887 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: asparagine-linked glycosylation 14 homolog (S. cerevisiae)".
  6. ^ Chantret I, Dancourt J, Barbat A, Moore SE (March 2005). "Two proteins homologous to the N- and C-terminal domains of the bacterial glycosyltransferase Murg are required for the second step of dolichyl-linked oligosaccharide synthesis in Saccharomyces cerevisiae". J. Biol. Chem. 280 (10): 9236–42. doi:10.1074/jbc.M413941200. PMID 15615718.
  7. ^ Averbeck N, Keppler-Ross S, Dean N (October 2007). "Membrane topology of the Alg14 endoplasmic reticulum UDP-GlcNAc transferase subunit". J. Biol. Chem. 282 (40): 29081–8. doi:10.1074/jbc.M704410200. PMID 17686769.