BCAS1 (original) (raw)

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Protein-coding gene in the species Homo sapiens

BCAS1
Identifiers
Aliases BCAS1, AIBC1, NABC1, breast carcinoma amplified sequence 1, brain enriched myelin associated protein 1, PMES-2
External IDs OMIM: 602968; MGI: 1924210; HomoloGene: 2714; GeneCards: BCAS1; OMA:BCAS1 - orthologs
Gene location (Human)Chromosome 20 (human)Chr.Chromosome 20 (human)[1]Chromosome 20 (human)Genomic location for BCAS1Genomic location for BCAS1Band20q13.2Start53,936,777 bp[1]End54,070,594 bp[1]
Gene location (Mouse)Chromosome 2 (mouse)Chr.Chromosome 2 (mouse)[2]Chromosome 2 (mouse)Genomic location for BCAS1Genomic location for BCAS1Band2|2 H3Start170,188,911 bp[2]End170,269,765 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inC1 segmentinferior ganglion of vagus nervecorpus callosumventral tegmental areasuperior vestibular nucleusmiddle frontal gyrusPonsinternal globus pallidusoptic nerveAmygdalaTop expressed indeep cerebellar nucleisubstantia nigrapontine nucleiglobus palliduslateral geniculate nucleussuprachiasmatic nucleussciatic nerveventral tegmental areaanterior horn of spinal cordmedial geniculate nucleusMore reference expression dataBioGPSMore reference expression data
OrthologsSpeciesHuman MouseEntrez853776960EnsemblENSG00000064787ENSMUSG00000013523UniProtO75363Q80YN3RefSeq (mRNA)NM_003657NM_001316361NM_001323347NM_001366295NM_001366296NM_001366297NM_001366298NM_001164369NM_029815RefSeq (protein)NP_001303290NP_001310276NP_003648NP_001353224NP_001353225NP_001353226NP_001353227NP_001157841NP_084091Location (UCSC)Chr 20: 53.94 – 54.07 MbChr 2: 170.19 – 170.27 MbPubMed search[3][4]
Wikidata
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Breast carcinoma-amplified sequence 1 is a protein that in humans is encoded by the BCAS1 gene.[5][6]

Breast carcinoma amplified sequence 1 (BCAS1) was isolated from a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, BCAS1 was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, the BCAS1 gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, BCAS1 is a candidate oncogene. It is predicted to encode a protein of 584 amino acids with no significant homology to other proteins.[6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000064787 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000013523 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Collins C, Rommens JM, Kowbel D, Godfrey T, Tanner M, Hwang SI, Polikoff D, Nonet G, Cochran J, Myambo K, Jay KE, Froula J, Cloutier T, Kuo WL, Yaswen P, Dairkee S, Giovanola J, Hutchinson GB, Isola J, Kallioniemi OP, Palazzolo M, Martin C, Ericsson C, Pinkel D, Albertson D, Li WB, Gray JW (Aug 1998). "Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma". Proc Natl Acad Sci U S A. 95 (15): 8703–8. Bibcode:1998PNAS...95.8703C. doi:10.1073/pnas.95.15.8703. PMC 21140. PMID 9671742.
  6. ^ a b "Entrez Gene: BCAS1 breast carcinoma amplified sequence 1".