C-myc internal ribosome entry site (IRES) (original) (raw)
From Wikipedia, the free encyclopedia
RNA family
| c-myc internal ribosome entry site (IRES) | |
|---|---|
 Predicted secondary structure and sequence conservation of IRES_c-myc |
|
| Identifiers | |
| Symbol | IRES_c-myc |
| Alt. Symbols | c-myc_IRES |
| Rfam | RF00216 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain | Eukaryota |
| GO | GO:0043022 |
| SO | SO:0000243 |
| PDB structures | PDBe |
The c-myc internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of C-myc and allows cap-independent translation. The mammalian c-myc gene is a proto-oncogene which is required for cell proliferation, transformation and death. c-myc mRNA has an alternative method of translation via internal ribosome entry where ribosomes are recruited to the IRES located in the 5' UTR thus bypassing the typical eukaryotic cap-dependent translation pathway.[1]
- ^ Le Quesne JP, Stoneley M, Fraser GA, Willis AE (June 2001). "Derivation of a structural model for the c-myc IRES". Journal of Molecular Biology. 310 (1): 111–126. doi:10.1006/jmbi.2001.4745. PMID 11419940.