CDC40 (original) (raw)

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Protein-coding gene in humans

CDC40
Identifiers
Aliases	CDC40, EHB3, PRP17, PRPF17, cell division cycle 40, PCH15
External IDs	OMIM: 605585; MGI: 1918963; HomoloGene: 5716; GeneCards: CDC40; OMA:CDC40 - orthologs
Gene location (Human)Chr.Chromosome 6 (human)[1]Band6q21Start110,180,141 bp[1]End110,254,275 bp[1]
Gene location (Mouse)Chr.Chromosome 10 (mouse)[2]Band10|10 B1Start40,707,617 bp[2]End40,759,307 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inmiddle temporal gyrusspermmononuclear cellAchilles tendonmonocytesecondary oocyteskin of hipmucosa of ileumbone marrowskin of thighTop expressed inhandlumbar subsegment of spinal cordRostral migratory streamgenital tubercleotolith organutriclezygoteinterventricular septumtail of embryoPaneth cellMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function protein binding RNA binding Cellular component catalytic step 2 spliceosome spliceosomal complex nucleoplasm nucleus U2-type catalytic step 2 spliceosome nuclear speck Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA processing mRNA export from nucleus mRNA 3'-end processing RNA splicing RNA export from nucleus Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez5136271713EnsemblENSG00000168438ENSMUSG00000038446UniProtO60508Q9DC48RefSeq (mRNA)NM_015891NM_027879RefSeq (protein)NP_056975NP_082155Location (UCSC)Chr 6: 110.18 – 110.25 MbChr 10: 40.71 – 40.76 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pre-mRNA-processing factor 17 is a protein that in humans is encoded by the CDC40 gene.[5][6][7]

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression.[7]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168438 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038446 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Ben Yehuda S, Dix I, Russell CS, Levy S, Beggs JD, Kupiec M (Oct 1998). "Identification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle control". RNA. 4 (10): 1304–12. doi:10.1017/S1355838298980712. PMC 1369702. PMID 9769104.
6. ^ Lindsey LA, Garcia-Blanco MA (Jan 1999). "Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p". J Biol Chem. 273 (49): 32771–5. doi:10.1074/jbc.273.49.32771. PMID 9830021.
7. ^ a b "Entrez Gene: CDC40 cell division cycle 40 homolog (S. cerevisiae)".

• Human CDC40 genome location and CDC40 gene details page in the UCSC Genome Browser.

• Wong WT, Schumacher C, Salcini AE, et al. (1995). "A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9530–4. Bibcode:1995PNAS...92.9530W. doi:10.1073/pnas.92.21.9530. PMC 40835. PMID 7568168.

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

• Salcini AE, Confalonieri S, Doria M, et al. (1997). "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module". Genes Dev. 11 (17): 2239–49. doi:10.1101/gad.11.17.2239. PMC 275390. PMID 9303539.

• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.

• Zhou Z, Reed R (1998). "Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing". EMBO J. 17 (7): 2095–106. doi:10.1093/emboj/17.7.2095. PMC 1170554. PMID 9524131.

• Ben-Yehuda S, Dix I, Russell CS, et al. (2001). "Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae". Genetics. 156 (4): 1503–17. doi:10.1093/genetics/156.4.1503. PMC 1461362. PMID 11102353.

• Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.

• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.