CPSF3 (original) (raw)

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Protein-coding gene in humans

CPSF3
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2I7T, 2I7V
Identifiers
Aliases	CPSF3, CPSF-73, CPSF73, cleavage and polyadenylation specific factor 3
External IDs	OMIM: 606029; MGI: 1859328; HomoloGene: 6499; GeneCards: CPSF3; OMA:CPSF3 - orthologs
Gene location (Human)Chr.Chromosome 2 (human)[1]Band2p25.1Start9,423,651 bp[1]End9,473,101 bp[1]
Gene location (Mouse)Chr.Chromosome 12 (mouse)[2]Band12|12 A1.3Start21,335,392 bp[2]End21,365,057 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inganglionic eminenceventricular zoneleft testisright testisendothelial celltendon of biceps brachiispermmonocytestromal cell of endometriumislet of LangerhansTop expressed inprimitive streakmedullary collecting ductureterinternal carotid arterycondylefossavas deferensEpithelium of choroid plexusexternal carotid arteryendothelial cell of lymphatic vesselMore reference expression dataBioGPSn/a
Gene ontologyMolecular function 5'-3' exonuclease activity metal ion binding endoribonuclease activity protein binding RNA binding nuclease activity endonuclease activity hydrolase activity Cellular component mRNA cleavage and polyadenylation specificity factor complex nucleoplasm nucleus Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA 3'-end processing by stem-loop binding and cleavage mRNA processing mRNA export from nucleus mRNA polyadenylation mRNA cleavage mRNA 3'-end processing RNA phosphodiester bond hydrolysis, endonucleolytic sno(s)RNA 3'-end processing snoRNA splicing pre-mRNA cleavage required for polyadenylation Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez5169254451EnsemblENSG00000119203ENSMUSG00000054309UniProtQ9UKF6Q9QXK7RefSeq (mRNA)NM_016207NM_001321833NM_001321834NM_001321835NM_001321836NM_018813NM_001364372NM_001364373RefSeq (protein)NP_001308762NP_001308763NP_001308764NP_001308765NP_057291NP_061283NP_001351301NP_001351302Location (UCSC)Chr 2: 9.42 – 9.47 MbChr 12: 21.34 – 21.37 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cleavage and polyadenylation specificity factor subunit 3 is a protein that in humans is encoded by the CPSF3 gene.[5][6]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119203 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054309 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Jenny A, Minvielle-Sebastia L, Preker PJ, Keller W (Dec 1996). "Sequence similarity between the 73-kilodalton protein of mammalian CPSF and a subunit of yeast polyadenylation factor I". Science. 274 (5292): 1514–7. Bibcode:1996Sci...274.1514J. doi:10.1126/science.274.5292.1514. PMID 8929409. S2CID 12958377.
6. ^ "Entrez Gene: CPSF3 cleavage and polyadenylation specific factor 3, 73kDa".

• Human CPSF3 genome location and CPSF3 gene details page in the UCSC Genome Browser.

• Murthy KG, Manley JL (1995). "The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation". Genes Dev. 9 (21): 2672–83. doi:10.1101/gad.9.21.2672. PMID 7590244.

• Jenny A, Hauri HP, Keller W (1994). "Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit". Mol. Cell. Biol. 14 (12): 8183–90. doi:10.1128/MCB.14.12.8183. PMC 359357. PMID 7969155.

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

• Thuresson AC, Aström J, Aström A, et al. (1994). "Multiple forms of poly(A) polymerases in human cells". Proc. Natl. Acad. Sci. U.S.A. 91 (3): 979–83. Bibcode:1994PNAS...91..979T. doi:10.1073/pnas.91.3.979. PMC 521437. PMID 8302877.

• McCracken S, Fong N, Yankulov K, et al. (1997). "The C-terminal domain of RNA polymerase II couples mRNA processing to transcription". Nature. 385 (6614): 357–61. Bibcode:1997Natur.385..357M. doi:10.1038/385357a0. PMID 9002523. S2CID 4307073.

• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.

• Takagaki Y, Manley JL (2000). "Complex protein interactions within the human polyadenylation machinery identify a novel component". Mol. Cell. Biol. 20 (5): 1515–25. doi:10.1128/MCB.20.5.1515-1525.2000. PMC 85326. PMID 10669729.

• de Vries H, Rüegsegger U, Hübner W, et al. (2000). "Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors". EMBO J. 19 (21): 5895–904. doi:10.1093/emboj/19.21.5895. PMC 305781. PMID 11060040.

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

• Kaufmann I, Martin G, Friedlein A, et al. (2005). "Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase". EMBO J. 23 (3): 616–26. doi:10.1038/sj.emboj.7600070. PMC 1271804. PMID 14749727.

• Calzado MA, Sancho R, Muñoz E (2004). "Human immunodeficiency virus type 1 Tat increases the expression of cleavage and polyadenylation specificity factor 73-kilodalton subunit modulating cellular and viral expression". J. Virol. 78 (13): 6846–54. doi:10.1128/JVI.78.13.6846-6854.2004. PMC 421638. PMID 15194760.

• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660.

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

• Mandel CR, Kaneko S, Zhang H, et al. (2007). "Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease". Nature. 444 (7121): 953–6. doi:10.1038/nature05363. PMC 3866582. PMID 17128255.

• de la Vega L, Sánchez-Duffhues G, Fresno M, et al. (2007). "The 73 kDa subunit of the CPSF complex binds to the HIV-1 LTR promoter and functions as a negative regulatory factor that is inhibited by the HIV-1 Tat protein". J. Mol. Biol. 372 (2): 317–30. doi:10.1016/j.jmb.2007.06.075. PMID 17669424.