CSRP2 (original) (raw)

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Protein-coding gene in humans

CSRP2
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CU8
Identifiers
Aliases	CSRP2, CRP2, LMO5, SmLIM, cysteine and glycine rich protein 2
External IDs	OMIM: 601871; MGI: 1202907; HomoloGene: 111061; GeneCards: CSRP2; OMA:CSRP2 - orthologs
Gene location (Human)Chr.Chromosome 12 (human)[1]Band12q21.2Start76,858,709 bp[1]End76,879,023 bp[1]
Gene location (Mouse)Chr.Chromosome 10 (mouse)[2]Band10|10 D1Start110,755,650 bp[2]End110,775,483 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inoocytesecondary oocyteganglionic eminencetibial arteriesright coronary arterymucosa of paranasal sinusparietal pleuragingival epitheliumgastric mucosaoptic nerveTop expressed inascending aortaaortic valvetunica media of zone of aortaumbilical cordendocardial cushionatriummandibular prominenceexternal carotid arteryatrioventricular valveinternal carotid arteryMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function protein binding metal ion binding molecular function structural constituent of muscle actinin binding Cellular component nucleus focal adhesion cytoplasm Z discdkac Biological process multicellular organism development cell differentiation actin cytoskeleton organization sarcomere organization muscle tissue development Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez146613008EnsemblENSG00000175183ENSMUSG00000020186UniProtQ16527P97314RefSeq (mRNA)NM_001300965NM_001321NM_007792RefSeq (protein)NP_001287894NP_001312NP_031818Location (UCSC)Chr 12: 76.86 – 76.88 MbChr 10: 110.76 – 110.78 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cysteine and glycine-rich protein 2 is a protein that in humans is encoded by the CSRP2 gene.[5][6][7]

CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3.[7]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175183 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020186 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Weiskirchen R, Pino JD, Macalma T, Bister K, Beckerle MC (Jan 1996). "The cysteine-rich protein family of highly related LIM domain proteins". J Biol Chem. 270 (48): 28946–54. doi:10.1074/jbc.270.48.28946. PMID 7499425.
6. ^ Weiskirchen R, Erdel M, Utermann G, Bister K (Nov 1997). "Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2". Genomics. 44 (1): 83–93. doi:10.1006/geno.1997.4855. PMID 9286703.
7. ^ a b "Entrez Gene: CSRP2 cysteine and glycine-rich protein 2".

• Human CSRP2 genome location and CSRP2 gene details page in the UCSC Genome Browser.

• Jain MK, Fujita KP, Hsieh CM, Endege WO, Sibinga NE, Yet SF, Kashiki S, Lee WS, Perrella MA (1996). "Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells". J. Biol. Chem. 271 (17): 10194–9. doi:10.1074/jbc.271.17.10194. PMID 8626582.

• Karim MA, Ohta K, Egashira M, Jinno Y, Niikawa N, Matsuda I, Indo Y (1997). "Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3". Genomics. 31 (2): 167–76. doi:10.1006/geno.1996.0028. PMID 8824798.

• Weiskirchen R, Gressner AM (2000). "The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP)". Biochem. Biophys. Res. Commun. 274 (3): 655–63. doi:10.1006/bbrc.2000.3187. PMID 10924333.

• Weiskirchen R, Moser M, Weiskirchen S, Erdel M, Dahmen S, Buettner R, Gressner AM (2001). "LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1". Biochem. J. 359 (Pt 3): 485–96. doi:10.1042/0264-6021:3590485. PMC 1222169. PMID 11672422.

• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

• Wang M, Hu Y, Shima I, Stearns ME (2003). "IL-10/IL-10 receptor signaling regulates TIMP-1 expression in primary human prostate tumor lines". Cancer Biol. Ther. 1 (5): 556–63. doi:10.4161/cbt.1.5.222. PMID 12496489.

• Stearns ME, Wang M, Hu Y, Garcia FU (2004). "Interleukin-10 activation of the interleukin-10E1 pathway and tissue inhibitor of metalloproteinase-1 expression is enhanced by proteasome inhibitors in primary prostate tumor lines". Mol. Cancer Res. 1 (9): 631–42. PMID 12861049.

• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.