E2F2 (original) (raw)

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

E2F2
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1N4M
Identifiers
Aliases E2F2, E2F-2, E2F transcription factor 2
External IDs OMIM: 600426; MGI: 1096341; HomoloGene: 48264; GeneCards: E2F2; OMA:E2F2 - orthologs
Gene location (Human)Chromosome 1 (human)Chr.Chromosome 1 (human)[1]Chromosome 1 (human)Genomic location for E2F2Genomic location for E2F2Band1p36.12Start23,506,438 bp[1]End23,531,233 bp[1]
Gene location (Mouse)Chromosome 4 (mouse)Chr.Chromosome 4 (mouse)[2]Chromosome 4 (mouse)Genomic location for E2F2Genomic location for E2F2Band4|4 D3Start135,899,705 bp[2]End135,923,368 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inbone marrowbone marrow cellstesticlebloodgonadmucosa of transverse colonganglionic eminenceventricular zonemonocytegranulocyteTop expressed inbloodgranulocytethymusotic vesiclehuman fetuszygotespleenprimary oocyteinternal carotid arteryhair follicleMore reference expression dataBioGPSn/a
Gene ontologyMolecular function DNA-binding transcription factor activity DNA binding transcription factor binding protein binding protein dimerization activity RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific Cellular component nucleus transcription regulator complex nucleoplasm RNA polymerase II transcription regulator complex Biological process regulation of cell cycle cell cycle transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated lens fiber cell apoptotic process intrinsic apoptotic signaling pathway by p53 class mediator transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of sprouting angiogenesis negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez1870242705EnsemblENSG00000007968ENSG00000282899ENSMUSG00000018983UniProtQ14209P56931RefSeq (mRNA)NM_004091NM_177733NM_183301NM_001305399RefSeq (protein)NP_004082NP_001292328NP_808401Location (UCSC)Chr 1: 23.51 – 23.53 MbChr 4: 135.9 – 135.92 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor E2F2 is a protein that in humans is encoded by the E2F2 gene.[5][6]

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.[7]

E2F2 has been shown to interact with:

  1. ^ a b c ENSG00000282899 GRCh38: Ensembl release 89: ENSG00000007968, ENSG00000282899 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018983 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ivey-Hoyle M, Conroy R, Huber HE, Goodhart PJ, Oliff A, Heimbrook DC (January 1994). "Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F". Mol Cell Biol. 13 (12): 7802–12. doi:10.1128/MCB.13.12.7802. PMC 364852. PMID 8246995.
  6. ^ Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K (January 1994). "The retinoblastoma protein binds to a family of E2F transcription factors". Mol Cell Biol. 13 (12): 7813–25. doi:10.1128/mcb.13.12.7813. PMC 364853. PMID 8246996.
  7. ^ "Entrez Gene: E2F2 E2F transcription factor 2".
  8. ^ Crowley TE, Kaine EM, Yoshida M, Nandi A, Wolgemuth DJ (August 2002). "Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein". Mol. Endocrinol. 16 (8): 1727–37. doi:10.1210/me.2001-0353. PMID 12145330. S2CID 14975453.
  9. ^ Denis GV, Vaziri C, Guo N, Faller DV (August 2000). "RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F". Cell Growth Differ. 11 (8): 417–24. PMC 3968681. PMID 10965846.
  10. ^ Schlisio S, Halperin T, Vidal M, Nevins JR (November 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". EMBO J. 21 (21): 5775–86. doi:10.1093/emboj/cdf577. PMC 131074. PMID 12411495.
  11. ^ Lee C, Chang JH, Lee HS, Cho Y (December 2002). "Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor". Genes Dev. 16 (24): 3199–212. doi:10.1101/gad.1046102. PMC 187509. PMID 12502741.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.