EMCN (original) (raw)

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Protein-coding gene in the species Homo sapiens

EMCN
Identifiers
Aliases	EMCN, EMCN2, MUC14, endomucin
External IDs	OMIM: 608350; MGI: 1891716; HomoloGene: 9438; GeneCards: EMCN; OMA:EMCN - orthologs
Gene location (Human)Chr.Chromosome 4 (human)[1]Band4q24Start100,395,341 bp[1]End100,880,126 bp[1]
Gene location (Mouse)Chr.Chromosome 3 (mouse)[2]Band3|3 G3Start137,046,828 bp[2]End137,137,946 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inAchilles tendonlower lobe of lungparietal pleuraskin of hiprenal medullaright lobe of thyroid glandvisceral pleurahuman kidneyright lunggallbladderTop expressed inleft lung lobeadrenal glandgenital tubercleatrioventricular valveright kidneyatriumcardiac muscle tissue of left ventricleinterventricular septumright lunghuman kidneyMore reference expression dataBioGPSMore reference expression data
OrthologsSpeciesHuman MouseEntrez5170559308EnsemblENSG00000164035ENSMUSG00000054690UniProtQ9ULC0Q9R0H2RefSeq (mRNA)NM_001159694NM_016242NM_001163522NM_016885RefSeq (protein)NP_001153166NP_057326NP_001156994NP_058581Location (UCSC)Chr 4: 100.4 – 100.88 MbChr 3: 137.05 – 137.14 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Endomucin is a protein that in humans is encoded by the EMCN gene.[5][6][7] Endomucin is a marker for endothelial cells[8] and hematopoietic stem cells.[9]

EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.[5][7]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164035 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054690 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ a b Kinoshita M, Nakamura T, Ihara M, Haraguchi T, Hiraoka Y, Tashiro K, Noda M (June 2001). "Identification of human endomucin-1 and -2 as membrane-bound O-sialoglycoproteins with anti-adhesive activity". FEBS Letters. 499 (1–2): 121–6. doi:10.1016/S0014-5793(01)02520-0. PMID 11418125. S2CID 23615506.
6. ^ Liu C, Shao ZM, Zhang L, Beatty P, Sartippour M, Lane T, Livingston E, Nguyen M (October 2001). "Human endomucin is an endothelial marker". Biochemical and Biophysical Research Communications. 288 (1): 129–36. doi:10.1006/bbrc.2001.5737. PMID 11594763.
7. ^ a b "Entrez Gene: EMCN endomucin".
8. ^ Liu C, et al. (2001). "Human Endomucin Is an Endothelial Marker". Biochemical and Biophysical Research Communications. 288 (1): 129–136. doi:10.1006/bbrc.2001.5737. PMID 11594763.
9. ^ Matsubara A.; et al. (2005). "Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development". Journal of Experimental Medicine. 11 (202): 1483–1492. doi:10.1084/jem.20051325. PMC 2213340. PMID 16314436.

• Li G, Miles A, Line A, Rees RC (March 2004). "Identification of tumour antigens by serological analysis of cDNA expression cloning". Cancer Immunology, Immunotherapy. 53 (3): 139–43. doi:10.1007/s00262-003-0471-y. PMC 11032928. PMID 14722670. S2CID 10785466.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Samulowitz U, Kuhn A, Brachtendorf G, Nawroth R, Braun A, Bankfalvi A, Böcker W, Vestweber D (May 2002). "Human endomucin: distribution pattern, expression on high endothelial venules, and decoration with the MECA-79 epitope". The American Journal of Pathology. 160 (5): 1669–81. doi:10.1016/S0002-9440(10)61114-5. PMC 1850881. PMID 12000719.
• Linē A, Stengrēvics A, Slucka Z, Li G, Jankevics E, Rees RC (June 2002). "Serological identification and expression analysis of gastric cancer-associated genes". British Journal of Cancer. 86 (11): 1824–30. doi:10.1038/sj.bjc.6600321. PMC 2375403. PMID 12087473.
• Kuhn A, Brachtendorf G, Kurth F, Sonntag M, Samulowitz U, Metze D, Vestweber D (December 2002). "Expression of endomucin, a novel endothelial sialomucin, in normal and diseased human skin". The Journal of Investigative Dermatology. 119 (6): 1388–93. doi:10.1046/j.1523-1747.2002.19647.x. PMID 12485444.
• Kanda H, Tanaka T, Matsumoto M, Umemoto E, Ebisuno Y, Kinoshita M, Noda M, Kannagi R, Hirata T, Murai T, Fukuda M, Miyasaka M (September 2004). "Endomucin, a sialomucin expressed in high endothelial venules, supports L-selectin-mediated rolling". International Immunology. 16 (9): 1265–74. doi:10.1093/intimm/dxh128. PMID 15249540.
• Reckzeh K.; Kizilkaya H.; Søgaard Helbo A.; Estruch Alrich M.; et al. (2018). "Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin". Blood Advances. 2 (13): 1628–1632. doi:10.1182/bloodadvances.2018015743. PMC 6039657. PMID 29986855.