ENTPD5 (original) (raw)

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Protein-coding gene in the species Homo sapiens

ENTPD5
Identifiers
Aliases	ENTPD5, CD39L4, NTPDase-5, PCPH, ectonucleoside triphosphate diphosphohydrolase 5, ectonucleoside triphosphate diphosphohydrolase 5 (inactive)
External IDs	OMIM: 603162; MGI: 1321385; HomoloGene: 37457; GeneCards: ENTPD5; OMA:ENTPD5 - orthologs
EC number	3.6.1.42
Gene location (Human)Chr.Chromosome 14 (human)[1]Band14q24.3Start73,958,010 bp[1]End74,019,399 bp[1]
Gene location (Mouse)Chr.Chromosome 12 (mouse)[2]Band12 D1|12 39.18 cMStart84,420,631 bp[2]End84,455,803 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inmucosa of sigmoid colonrectumjejunal mucosaduodenumlivermucosa of transverse colonright lobe of liverhuman kidneyepithelium of colonmucosa of ileumTop expressed inproximal tubuleright kidneyhuman kidneyleft lobe of livertransitional epithelium of urinary bladderolfactory epitheliumesophagusright ventriclejejunumduodenumMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function guanosine-diphosphatase activity uridine-diphosphatase activity protein binding hydrolase activity nucleoside-diphosphatase activity Cellular component endoplasmic reticulum extracellular region Biological process 'de novo' posttranslational protein folding ATP metabolic process protein glycosylation protein N-linked glycosylation cell population proliferation positive regulation of glycolytic process regulation of phosphatidylinositol 3-kinase signaling nucleobase-containing small molecule catabolic process Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez95712499EnsemblENSG00000187097ENSMUSG00000021236UniProtO75356Q9WUZ9RefSeq (mRNA)NM_001249NM_001321984NM_001321985NM_001321986NM_001321987NM_001321988NM_001330189NM_001382256NM_001382257NM_001382258NM_001382259NM_001382260NM_001382262NM_001382263NM_001026214NM_001286049NM_001286058NM_007647RefSeq (protein)NP_001240NP_001308913NP_001308914NP_001308915NP_001308916NP_001308917NP_001317118NP_001369185NP_001369186NP_001369187NP_001369188NP_001369189NP_001369191NP_001369192NP_001021385NP_001272978NP_001272987NP_031673Location (UCSC)Chr 14: 73.96 – 74.02 MbChr 12: 84.42 – 84.46 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ectonucleoside triphosphate diphosphohydrolase 5 is an enzyme that in humans is encoded by the ENTPD5 gene.[5][6][7]

ENTPD5 is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases.[7]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187097 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021236 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Chadwick BP, Frischauf AM (Oct 1997). "Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes". Mamm Genome. 8 (9): 668–72. doi:10.1007/s003359900534. PMID 9271669. S2CID 42644202.
6. ^ Chadwick BP, Frischauf AM (Oct 1998). "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster". Genomics. 50 (3): 357–67. doi:10.1006/geno.1998.5317. PMID 9676430.
7. ^ a b "Entrez Gene: ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5".

• Mulero JJ, Yeung G, Nelken ST, Ford JE (1999). "CD39-L4 is a secreted human apyrase, specific for the hydrolysis of nucleoside diphosphates". J. Biol. Chem. 274 (29): 20064–7. doi:10.1074/jbc.274.29.20064. PMID 10400613.
• Recio JA, Zambrano N, Peña L, et al. (2000). "The human PCPH proto-oncogene: cDNA identification, primary structure, chromosomal mapping, and expression in normal and tumor cells". Mol. Carcinog. 27 (3): 229–36. doi:10.1002/(SICI)1098-2744(200003)27:3<229::AID-MC10>3.0.CO;2-Z. PMID 10708485. S2CID 21222716.
• Mulero JJ, Yeung G, Nelken ST, et al. (2000). "Biochemical characterization of CD39L4". Biochemistry. 39 (42): 12924–8. doi:10.1021/bi000960y. PMID 11041857.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Blánquez MJ, Regadera J, Mariño J, et al. (2003). "Gradual deregulation and loss of PCPH expression in the progression of human laryngeal neoplasia". Mol. Carcinog. 35 (4): 186–95. doi:10.1002/mc.10091. PMID 12489110. S2CID 24074840.
• Murphy-Piedmonte DM, Crawford PA, Kirley TL (2005). "Bacterial expression, folding, purification and characterization of soluble NTPDase5 (CD39L4) ecto-nucleotidase". Biochim. Biophys. Acta. 1747 (2): 251–9. doi:10.1016/j.bbapap.2004.11.017. PMID 15698960.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Regadera J, Blánquez MJ, González-Peramato P, et al. (2006). "PCPH expression is an early event in the development of testicular germ cell tumors". Int. J. Oncol. 28 (3): 595–604. doi:10.3892/ijo.28.3.595. PMID 16465363.
• Villar J, Arenas MI, MacCarthy CM, et al. (2007). "PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism". Cancer Res. 67 (22): 10859–68. doi:10.1158/0008-5472.CAN-07-2041. PMID 18006831.