EPHA10 (original) (raw)

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Protein-coding gene in the species Homo sapiens

EPHA10
Identifiers
Aliases	EPHA10, EPH receptor A10
External IDs	OMIM: 611123; MGI: 3586824; HomoloGene: 67804; GeneCards: EPHA10; OMA:EPHA10 - orthologs
Gene location (Human)Chr.Chromosome 1 (human)[1]Band1p34.3Start37,713,880 bp[1]End37,765,133 bp[1]
Gene location (Mouse)Chr.Chromosome 4 (mouse)[2]Band4|4 D2.2Start124,880,899 bp[2]End124,917,800 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inspermmucosa of transverse colonleft testisright testisrectummucosa of ileumright frontal lobeBrodmann area 9nucleus accumbensepithelium of colonTop expressed inpiriform cortexprimary visual cortexsuperior colliculusventral tegmental areasuperior frontal gyruspontine nucleimedial vestibular nucleusmedial dorsal nucleusdorsal tegmental nucleusinferior colliculiMore reference expression dataBioGPSn/a
Gene ontologyMolecular function transferase activity nucleotide binding protein kinase activity transmembrane-ephrin receptor activity kinase activity protein binding transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding ephrin receptor activity receptor tyrosine kinase transmembrane signaling receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane extracellular region cytoplasm neuron projection receptor complex Biological process phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway protein phosphorylation peptidyl-tyrosine phosphorylation ephrin receptor signaling pathway biological process negative regulation of signal transduction cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade axon guidance Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez284656230735EnsemblENSG00000183317ENSMUSG00000028876UniProtQ5JZY3Q8BYG9RefSeq (mRNA)NM_001004338NM_001099439NM_173641NM_001256432NM_177671RefSeq (protein)NP_001092909NP_775912NP_001243361NP_808339Location (UCSC)Chr 1: 37.71 – 37.77 MbChr 4: 124.88 – 124.92 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

EPH receptor A10 is a protein in humans that is encoded by the EPHA10 gene.[5]

Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells.[5]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183317 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028876 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ a b Aasheim HC, Patzke S, Hjorthaug HS, Finne EF (May 2005). "Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis". Biochimica et Biophysica Acta (BBA) - General Subjects. 1723 (1–3): 1–7. doi:10.1016/j.bbagen.2005.01.011. PMID 15777695.