EXOC6 (original) (raw)

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Protein-coding gene in the species Homo sapiens

EXOC6
Identifiers
Aliases EXOC6, EXOC6A, SEC15, SEC15L, SEC15L1, SEC15L3, Sec15p, exocyst complex component 6
External IDs OMIM: 609672; MGI: 1351611; HomoloGene: 41305; GeneCards: EXOC6; OMA:EXOC6 - orthologs
Gene location (Human)Chromosome 10 (human)Chr.Chromosome 10 (human)[1]Chromosome 10 (human)Genomic location for EXOC6Genomic location for EXOC6Band10q23.33Start92,826,831 bp[1]End93,059,493 bp[1]
Gene location (Mouse)Chromosome 19 (mouse)Chr.Chromosome 19 (mouse)[2]Chromosome 19 (mouse)Genomic location for EXOC6Genomic location for EXOC6Band19 C2|19 32.32 cMStart37,509,327 bp[2]End37,672,507 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed indeltoid musclepancreatic epithelial cellvastus lateralis musclemiddle temporal gyrustibialis anterior musclebuccal mucosa cellSkeletal muscle tissue of biceps brachiiSkeletal muscle tissue of rectus abdominisislet of LangerhansplacentaTop expressed insoleus muscleextraocular muscledigastric musclesternocleidomastoid muscletemporal muscleintercostal muscletriceps brachii musclegranulocytethoracic diaphragmRegion I of hippocampus properMore reference expression dataBioGPSn/a
Gene ontologyMolecular function protein binding Cellular component cytosol plasma membrane exocyst cytoplasm growth cone cell projection perinuclear region of cytoplasm Flemming body membrane Biological process protein transport vesicle docking involved in exocytosis exocytosis Golgi to plasma membrane transport Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez54536107371EnsemblENSG00000138190ENSMUSG00000053799UniProtQ8TAG9Q8R313RefSeq (mRNA)NM_001013848NM_019053NM_001319194NM_001319195NM_001319200NM_175353RefSeq (protein)NP_001013870NP_001306123NP_001306124NP_001306129NP_061926n/aLocation (UCSC)Chr 10: 92.83 – 93.06 MbChr 19: 37.51 – 37.67 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Exocyst complex component 6 is a protein that in humans is encoded by the EXOC6 gene.[5]

The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring cytochrome p450 genes are included in a deletion that results in an autosomal dominant form of nonsyndromic optic nerve aplasia (ONA). Alternative splicing and the use of alternative promoters results in multiple transcript variants. A paralogous gene encoding a similar protein is present on chromosome 2.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138190 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053799 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Exocyst complex component 6".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.