FLVCR1 (original) (raw)

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Protein-coding gene in the species Homo sapiens

FLVCR1
Identifiers
Aliases FLVCR1, AXPC1, FLVCR, MFSD7B, PCA, PCARP, feline leukemia virus subgroup C cellular receptor 1, SLC49A1, FLVCR heme transporter 1
External IDs OMIM: 609144; MGI: 2444881; HomoloGene: 56661; GeneCards: FLVCR1; OMA:FLVCR1 - orthologs
Gene location (Human)Chromosome 1 (human)Chr.Chromosome 1 (human)[1]Chromosome 1 (human)Genomic location for FLVCR1Genomic location for FLVCR1Band1q32.3Start212,858,275 bp[1]End212,899,363 bp[1]
Gene location (Mouse)Chromosome 1 (mouse)Chr.Chromosome 1 (mouse)[2]Chromosome 1 (mouse)Genomic location for FLVCR1Genomic location for FLVCR1Band1|1 H6Start190,738,044 bp[2]End190,758,355 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed injejunal mucosamucosa of ileumpancreatic epithelial cellcorpus epididymisbronchial epithelial cellbuccal mucosa cellduodenumgerminal epitheliumpylorusretinal pigment epitheliumTop expressed inepithelium of small intestineciliary bodytemporal musclemigratory enteric neural crest cellgranulocytetriceps brachii muscleintercostal muscleileumdigastric musclestroma of bone marrowMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function transporter activity protein binding heme transmembrane transporter activity heme binding Cellular component integral component of membrane mitochondrial membranes membrane plasma membrane integral component of plasma membrane mitochondrion Biological process embryonic skeletal system morphogenesis head morphogenesis limb morphogenesis multicellular organism growth embryonic digit morphogenesis in utero embryonic development mitochondrial transport spleen development heme transport multicellular organism development blood vessel development erythrocyte differentiation regulation of organ growth heme export cellular iron ion homeostasis erythrocyte maturation transmembrane transport Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez28982226844EnsemblENSG00000162769ENSMUSG00000066595UniProtQ9Y5Y0B2RXV4RefSeq (mRNA)NM_014053NM_001081259NM_001313747NM_198025RefSeq (protein)NP_054772NP_001074728NP_001300676NP_932142Location (UCSC)Chr 1: 212.86 – 212.9 MbChr 1: 190.74 – 190.76 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Feline leukemia virus subgroup C receptor-related protein 1 is a protein that in humans is encoded by the FLVCR1 gene (SLC49A1).[5][6][7][8]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162769 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000066595 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tailor CS, Willett BJ, Kabat D (1999). "A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily". J. Virol. 73 (8): 6500–5. doi:10.1128/JVI.73.8.6500-6505.1999. PMC 112732. PMID 10400745.
  6. ^ Quigley JG, Burns CC, Anderson MM, Lynch ED, Sabo KM, Overbaugh J, Abkowitz JL (2000). "Cloning of the cellular receptor for feline leukemia virus subgroup C (FeLV-C), a retrovirus that induces red cell aplasia". Blood. 95 (3): 1093–9. doi:10.1182/blood.V95.3.1093.003k01_1093_1099. PMID 10648427.
  7. ^ "Entrez Gene: FLVCR feline leukemia virus subgroup C cellular receptor".
  8. ^ Crielaard, Bart J.; Lammers, Twan; Rivella, Stefano (2017-02-03). "Targeting iron metabolism in drug discovery and delivery". Nature Reviews Drug Discovery. advance online publication (6): 400–423. doi:10.1038/nrd.2016.248. ISSN 1474-1784. PMC 5455971. PMID 28154410.