FOXF1 (original) (raw)

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Protein-coding gene in the species Homo sapiens

FOXF1
Identifiers
Aliases FOXF1, ACDMPV, FKHL5, FREAC1, forkhead box F1
External IDs OMIM: 601089; MGI: 1347470; HomoloGene: 1114; GeneCards: FOXF1; OMA:FOXF1 - orthologs
Gene location (Human)Chromosome 16 (human)Chr.Chromosome 16 (human)[1]Chromosome 16 (human)Genomic location for FOXF1Genomic location for FOXF1Band16q24.1Start86,510,527 bp[1]End86,515,422 bp[1]
Gene location (Mouse)Chromosome 8 (mouse)Chr.Chromosome 8 (mouse)[2]Chromosome 8 (mouse)Genomic location for FOXF1Genomic location for FOXF1Band8 E1|8 70.31 cMStart121,811,125 bp[2]End121,814,883 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inmuscle layer of sigmoid colongastric mucosaright lunglower lobe of lungurinary bladdermucosa of urinary bladderbuccal mucosa cellupper lobe of lungupper lobe of left lungpylorusTop expressed inright lung lobeleft lung lobemigratory enteric neural crest cellmolarsomatopleuric mesenchymelamina propria of urethramandibular prominenceurinary bladderextraembryonic membraneyolk sacMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function DNA binding sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription regulator complex nucleus Biological process somitogenesis regulation of smooth muscle cell differentiation renal system development ureter development regulation of transcription, DNA-templated lung morphogenesis embryonic foregut morphogenesis lung development positive regulation of cell migration endocardial cushion development cellular response to organic cyclic compound extracellular matrix organization cardiac left ventricle morphogenesis in utero embryonic development negative regulation of transcription by RNA polymerase II negative regulation of mast cell degranulation smooth muscle cell differentiation morphogenesis of a branching structure venous blood vessel development cellular response to cytokine stimulus right lung morphogenesis transcription, DNA-templated vasculogenesis positive regulation of transcription, DNA-templated respiratory tube development heart development determination of left/right symmetry establishment of epithelial cell apical/basal polarity blood vessel development embryonic ectodermal digestive tract morphogenesis positive regulation of mesenchymal cell proliferation embryonic digestive tract morphogenesis animal organ morphogenesis pancreas development detection of wounding mesenchyme migration smoothened signaling pathway lateral mesodermal cell differentiation lung alveolus development digestive tract development lung vasculature development mesoderm development epithelial tube branching involved in lung morphogenesis negative regulation of inflammatory response lung lobe morphogenesis ductus arteriosus closure embryonic digestive tract development positive regulation of transcription by RNA polymerase II epithelial cell differentiation involved in mammary gland alveolus development midgut development positive regulation of cell-substrate adhesion transcription by RNA polymerase II cell differentiation cell-cell adhesion trachea development Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez229415227EnsemblENSG00000103241ENSMUSG00000042812UniProtQ12946Q61080RefSeq (mRNA)NM_001451NM_010426RefSeq (protein)NP_001442NP_034556Location (UCSC)Chr 16: 86.51 – 86.52 MbChr 8: 121.81 – 121.81 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Forkhead box protein F1 (FOXF1) is a protein that in humans is encoded by the FOXF1 gene.[5][6][7]

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. FOX1 protein is important in the development of the pulmonary mesenchyme and the development of the gastrointestinal tract.[8]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103241 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042812 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^
  6. ^ Pierrou S, Hellqvist M, Samuelsson L, Enerbäck S, Carlsson P (Oct 1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". The EMBO Journal. 13 (20): 5002–12. doi:10.1002/j.1460-2075.1994.tb06827.x. PMC 395442. PMID 7957066.
  7. ^ "Entrez Gene: FOXF1 forkhead box F1".
  8. ^ "FOXF1 gene: MedlinePlus Genetics". medlineplus.gov. Retrieved 2021-06-10.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.