FPGT (original) (raw)

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Protein-coding gene in the species Homo sapiens

FPGT
Identifiers
Aliases FPGT, GFPP, fucose-1-phosphate guanylyltransferase
External IDs OMIM: 603609; MGI: 1922790; HomoloGene: 2847; GeneCards: FPGT; OMA:FPGT - orthologs
Gene location (Human)Chromosome 1 (human)Chr.Chromosome 1 (human)[1]Chromosome 1 (human)Genomic location for FPGTGenomic location for FPGTBand1p31.1Start74,198,238 bp[1]End74,234,086 bp[1]
Gene location (Mouse)Chromosome 3 (mouse)Chr.Chromosome 3 (mouse)[2]Chromosome 3 (mouse)Genomic location for FPGTGenomic location for FPGTBand3|3 H4Start154,790,555 bp[2]End154,799,040 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inmonocytegonadAchilles tendongallbladdersecondary oocytetesticlerectumislet of Langerhansjejunal mucosaventricular zoneTop expressed inzygotesecondary oocyteinterventricular septumprimary oocyteolfactory epitheliumislet of Langerhansepithelium of small intestineEpithelium of choroid plexusotolith organRegion I of hippocampus properMore reference expression dataBioGPSn/a
Gene ontologyMolecular function transferase activity nucleotide binding transferase activity, transferring phosphorus-containing groups nucleotidyltransferase activity GTP binding catalytic activity fucose-1-phosphate guanylyltransferase activity Cellular component cytoplasm cytosol Biological process fucose metabolic process Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez879075540EnsemblENSG00000254685ENSMUSG00000053870UniProtO14772G5E8F4RefSeq (mRNA)NM_003838NM_001199328NM_001199329NM_029330RefSeq (protein)NP_001186257NP_001186258NP_003829NP_083606Location (UCSC)Chr 1: 74.2 – 74.23 MbChr 3: 154.79 – 154.8 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fucose-1-phosphate guanylyltransferase is an enzyme that in humans is encoded by the FPGT gene.[5][6]

L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell–cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose.

There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.

This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose.[6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000254685Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053870Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pastuszak I, Ketchum C, Hermanson G, Sjoberg EJ, Drake R, Elbein AD (Dec 1998). "GDP-L-fucose pyrophosphorylase. Purification, cDNA cloning, and properties of the enzyme". J Biol Chem. 273 (46): 30165–74. doi:10.1074/jbc.273.46.30165. PMID 9804772.
  6. ^ a b "Entrez Gene: FPGT fucose-1-phosphate guanylyltransferase".