FRMD6 (original) (raw)

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Protein-coding gene in the species Homo sapiens

FRMD6
Identifiers
Aliases	FRMD6, C14orf31, EX1, Willin, c14_5320, FERM domain containing 6
External IDs	OMIM: 614555; MGI: 2442579; HomoloGene: 12449; GeneCards: FRMD6; OMA:FRMD6 - orthologs
Gene location (Human)Chr.Chromosome 14 (human)[1]Band14q22.1Start51,489,100 bp[1]End51,730,727 bp[1]
Gene location (Mouse)Chr.Chromosome 12 (mouse)[2]Band12|12 C2Start70,872,288 bp[2]End70,949,008 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inskin of armcartilage tissuetibiatail of epididymisstromal cell of endometriumepithelium of lactiferous glandlactiferous ductoral cavityskin of thighskin of hipTop expressed incalvariaskin of external earhair follicleankle jointbody of femurskin of backcorneal stromalipconjunctival fornixsciatic nerveMore reference expression dataBioGPSn/a
Gene ontologyMolecular function protein binding structural constituent of cytoskeleton Cellular component apical junction complex plasma membrane membrane cytoplasm cytoskeleton Biological process regulation of actin filament-based process apical constriction actomyosin structure organization Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez122786319710EnsemblENSG00000139926ENSMUSG00000048285UniProtQ96NE9Q8C0V9RefSeq (mRNA)NM_001042481NM_001267046NM_001267047NM_152330NM_028127RefSeq (protein)NP_001035946NP_001253975NP_001253976NP_689543NP_082403Location (UCSC)Chr 14: 51.49 – 51.73 MbChr 12: 70.87 – 70.95 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FERM domain-containing protein 6 is a protein that in humans is encoded by the FRMD6 gene.[5]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139926 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048285 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: FRMD6 FERM domain containing 6".

• Kronenberg NM, Tilston-Lunel A, Thompson FE, Chen D, Yu W, Dholakia K, Gather MC, Gunn-Moore FJ (2020). "Willin/FRMD6 Influences Mechanical Phenotype and Neuronal Differentiation in Mammalian Cells by Regulating ERK1/2 Activity". Frontiers in Cellular Neuroscience. 14: 552213. doi:10.3389/fncel.2020.552213. PMC 7498650. PMID 33088261.
• Moleirinho S, Patrick C, Tilston-Lünel AM, Higginson JR, Angus L, Antkowiak M, Barnett SC, Prystowsky MB, Reynolds PA, Gunn-Moore FJ (2013). "Willin, an Upstream Component of the Hippo Signaling Pathway, Orchestrates Mammalian Peripheral Nerve Fibroblasts". PLOS ONE. 8 (4): e60028. Bibcode:2013PLoSO...860028M. doi:10.1371/journal.pone.0060028. PMC 3620498. PMID 23593160.
• Angus L, Moleirinho S, Herron L, Sinha A, Zhang X, Niestrata M, Dholakia K, Prystowsky MB, Harvey KF, Reynolds PA, Gunn-Moore FJ (January 2012). "Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP". Oncogene. 31 (2): 238–50. doi:10.1038/onc.2011.224. hdl:10023/2489. PMID 21666719.
• Madan R, Brandwein-Gensler M, Schlecht NF, Elias K, Gorbovitsky E, Belbin TJ, Mahmood R, Breining D, Qian H, Childs G, Locker J, Smith R, Haigentz M, Gunn-Moore F, Prystowsky MB (November 2006). "Differential tissue and subcellular expressionof ERM proteins in normal and malignant tissues: cytoplasmic ezrin expression has prognostic significance for head and neck squamous cell carcinoma". Head & Neck. 28 (11): 1018–27. doi:10.1002/hed.20435. PMID 16783828. S2CID 32305188.
• Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C, Jafar-Nejad H, Halder G (January 2006). "The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis". Nature Cell Biology. 8 (1): 27–36. doi:10.1038/ncb1339. PMID 16341207. S2CID 15468669.
• Gunn-Moore FJ, Welsh GI, Herron LR, Brannigan F, Venkateswarlu K, Gillespie S, Brandwein-Gensler M, Madan R, Tavaré JM, Brophy PJ, Prystowsky MB, Guild S (September 2005). "A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'" (PDF). FEBS Letters. 579 (22): 5089–94. doi:10.1016/j.febslet.2005.07.097. PMID 16137681.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.