GRAP (original) (raw)

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Protein-coding gene in humans

GRAP
Identifiers
Aliases	GRAP, GRB2-related adaptor protein, GRB2 related adaptor protein, DFNB114
External IDs	OMIM: 604330; MGI: 1918770; HomoloGene: 4822; GeneCards: GRAP; OMA:GRAP - orthologs
Gene location (Human)Chr.Chromosome 17 (human)[1]Band17p11.2Start19,020,656 bp[1]End19,047,011 bp[1]
Gene location (Mouse)Chr.Chromosome 11 (mouse)[2]Band11|11 B2Start61,544,091 bp[2]End61,563,610 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inspleengranulocytelymph nodebloodright lungupper lobe of left lunggallbladderapex of heartappendixright lobe of thyroid glandTop expressed inmesenteric lymph nodesthymusspleenright lung lobebloodlipsubcutaneous adipose tissueembryoleft lung loberight kidneyMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function protein binding non-membrane spanning protein tyrosine kinase activity signaling receptor binding Cellular component cytoplasm cytosol extrinsic component of cytoplasmic side of plasma membrane Biological process cell-cell signaling Ras protein signal transduction positive regulation of signal transduction transmembrane receptor protein tyrosine kinase signaling pathway cell migration cell differentiation peptidyl-tyrosine autophosphorylation regulation of cell population proliferation innate immune response Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez1075071520EnsemblENSG00000154016ENSMUSG00000004837UniProtQ13588Q9CX99RefSeq (mRNA)NM_006613NM_001330148NM_027817RefSeq (protein)NP_001317077NP_006604NP_082093Location (UCSC)Chr 17: 19.02 – 19.05 MbChr 11: 61.54 – 61.56 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GRB2-related adapter protein is a protein that in humans is encoded by the GRAP gene.[5][6][7]

This gene encodes a member of the GRB2/Sem5 (C. elegans homolog)/Drk (Drosophila homolog) family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.[7]

GRAP has been shown to interact with Linker of activated T cells.[8][9]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154016 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004837 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J (May 1996). "Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway". The Journal of Biological Chemistry. 271 (21): 12129–32. doi:10.1074/jbc.271.21.12129. PMID 8647802.
6. ^ Trüb T, Frantz JD, Miyazaki M, Band H, Shoelson SE (Jan 1997). "The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling". The Journal of Biological Chemistry. 272 (2): 894–902. doi:10.1074/jbc.272.2.894. PMID 8995379.
7. ^ a b "Entrez Gene: GRAP GRB2-related adaptor protein".
8. ^ Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE (Jan 1998). "LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation". Cell. 92 (1): 83–92. doi:10.1016/S0092-8674(00)80901-0. PMID 9489702. S2CID 1806525.
9. ^ Perez-Villar JJ, Whitney GS, Sitnick MT, Dunn RJ, Venkatesan S, O'Day K, Schieven GL, Lin TA, Kanner SB (Aug 2002). "Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav". Biochemistry. 41 (34): 10732–40. doi:10.1021/bi025554o. PMID 12186560.

• Welsh M, Songyang Z, Frantz JD, Trüb T, Reedquist KA, Karlsson T, Miyazaki M, Cantley LC, Band H, Shoelson SE (Feb 1998). "Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins". Oncogene. 16 (7): 891–901. doi:10.1038/sj.onc.1201607. PMID 9484780. S2CID 28452652.
• Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE (Jan 1998). "LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation". Cell. 92 (1): 83–92. doi:10.1016/S0092-8674(00)80901-0. PMID 9489702. S2CID 1806525.
• Wenzel J, Sanzenbacher R, Ghadimi M, Lewitzky M, Zhou Q, Kaplan DR, Kabelitz D, Feller SM, Janssen O (Dec 2001). "Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor". FEBS Letters. 509 (2): 255–62. doi:10.1016/S0014-5793(01)03174-X. PMID 11741599. S2CID 33084576.
• Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS (Sep 2003). "GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2". The Journal of Biological Chemistry. 278 (36): 34641–53. doi:10.1074/jbc.M304594200. PMID 12819203.
• Shiraiwa H, Takei M, Yoshikawa T, Azuma T, Kato M, Mitamura K, Ueki T, Kida A, Horie T, Seki N, Sawada S (2004). "Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sjögren's syndrome". The Journal of International Medical Research. 32 (3): 284–91. doi:10.1177/147323000403200308. PMID 15174222.