GSTM3 (original) (raw)

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Protein-coding gene in the species Homo sapiens

GSTM3
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3GTU
Identifiers
Aliases GSTM3, GST5, GSTB, GSTM3-3, GTM3, glutathione S-transferase mu 3 (brain), glutathione S-transferase mu 3
External IDs OMIM: 138390; MGI: 1309466; HomoloGene: 658; GeneCards: GSTM3; OMA:GSTM3 - orthologs
Gene location (Human)Chromosome 1 (human)Chr.Chromosome 1 (human)[1]Chromosome 1 (human)Genomic location for GSTM3Genomic location for GSTM3Band1p13.3Start109,733,932 bp[1]End109,741,038 bp[1]
Gene location (Mouse)Chromosome 3 (mouse)Chr.Chromosome 3 (mouse)[2]Chromosome 3 (mouse)Genomic location for GSTM3Genomic location for GSTM3Band3|3 F2.3Start107,803,137 bp[2]End107,806,002 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inright testisleft testismale germ cellspermseminal vesiculacorpus epididymisrenal medullaright ovaryleft ovaryapex of heartTop expressed inseminiferous tubulespermatidefferent ductulespermatocyteCA3 fieldolfactory epitheliumentorhinal cortexperirhinal cortexchoroid plexus of fourth ventricleoptic nerveMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function transferase activity enzyme binding glutathione transferase activity protein homodimerization activity glutathione binding identical protein binding protein binding Cellular component cytoplasm cytosol sperm fibrous sheath extracellular exosome nucleus intercellular bridge Biological process cellular detoxification of nitrogen compound metabolism nitrobenzene metabolic process xenobiotic catabolic process glutathione derivative biosynthetic process glutathione metabolic process response to estrogen establishment of blood-nerve barrier Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez294714866EnsemblENSG00000134202ENSMUSG00000004032UniProtP21266Q6FGJ9P48774RefSeq (mRNA)NM_000849NM_010360RefSeq (protein)NP_000840NP_000840.2NP_034490Location (UCSC)Chr 1: 109.73 – 109.74 MbChr 3: 107.8 – 107.81 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glutathione S-transferase M3 (brain), also known as GSTM2, is an enzyme which in humans is encoded by the GSTM99 gene.[5][6]

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including some carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins.[5]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134202 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004032 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: GSTM3 glutathione S-transferase M3 (brain)".
  6. ^ Campbell E, Takahashi Y, Abramovitz M, Peretz M, Listowsky I (June 1990). "A distinct human testis and brain mu-class glutathione S-transferase. Molecular cloning and characterization of a form present even in individuals lacking hepatic type mu isoenzymes". J. Biol. Chem. 265 (16): 9188–93. doi:10.1016/S0021-9258(19)38830-1. PMID 2345169.